Clinical Surgery

Stephen Knight

Stephen is a general surgical registrar and NIHR Clinical Research Fellow who is undertaking a PhD based in Global Surgery and mobile technology to measure surgical outcomes with the Usher Institute.

Stephen Knight

NIHR Clinical Research Fellow

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Stephen was appointed to the South-East Scotland Academic Foundation Programme following the award of his MB ChB (Hons) at the University of Leicester. During his medical school training he was awarded the Roche Pharmaceuticals People & Disease Dissertation Prize and multiple distinctions, while also undertaking an intercalated BSc (1st Class Hons).

Since graduation Stephen has been awarded outstanding performer in the CcRISP (RCSEng) and ATLS courses, together with continuing his focus on surgical academia. He has recently completed a national research prioritisation exercise in HPB surgery, part of the GlobalSurg 3 steering committee ( and co-founder of the Edinburgh MedTech Foundation.

Global surgery has been a neglected field over the past 20 years, despite surgically treatable conditions representing around 30% of the global burden of disease. However, it is now becoming an academic focus globally and has been the subject of a Lancet Global Commission (Global Surgery 2030). Currently 5 billion people lack access to safe, affordable surgical care while 33 million face catastrophic health expenditure each year.


Decision modelling in donation after circulatory death (DCD) liver transplantation. McLean KA, Camilleri-Brennan J, Knight SR, Drake T, Ots R, Shaw CA, Wigmore SJ, Harrison EM. Liver Transplantation, 23 p594-603, 2017.

Use of renal replacement therapy may influence graft outcomes following liver transplantation for acute liver failure: a propensity-score matched population-based retrospective cohort study. Knight SR, Oniscu GC, Devey L, Simpson KJ, Wigmore SJ, Harrison EM. PLoS One, 11(3), e0148782, 2016.

Allopregnanolone protects against dopamine-induced striatal damage after in vitro ischaemia via interaction at GABAAreceptors. Knight SR, Davidson C, Young AMJ, Gibson CL.Journal of Neuroendocrinology, 24 p1-9, 2012.

Global inequities in precision medicine and molecular cancer research. Drake TM, Knight SR, Harrison EM, Køreide K. Frontiers in Oncology 2018: 8, 346.

Patient consent in the post-Montgomery era: a national multi-speciality prospective study. Knight SR, Pearson R, Healy K, Lee G, MacDonald AJ, Macdonald A. The Surgeon, in press.

Systematic review on the use of big data to improve surgery in low- and middle-income countries. Knight SR, Ots R, Maimbo M, Drake TM, Fairfield CJ, Harrison EM. BJS 2019: 106 (2), e62-e72.

Use of the surgical safety checklist and outcomes after emergency laparotomy: A pooled analysis of two international, prospective, cohort studies. GlobalSurg Collaborative (Writing group). BJS, 106 (2), e103-e112.

Quality and outcomes in global cancer surgery: protocol for a multicentre, international, prospective cohort study (GlobalSurg 3) BMJ Open, in press GlobalSurg collaborative (Writing group, first author).

Use of a modified Delphi approach to develop research priorities in HPB surgery across the United Kingdom HPB, in press SR Knight, S Pathak, A Christie, L Jones, J Rees, H Davies, MSJ Wilson, P Vaughan-Shaw, K Roberts, G Toogood, EM Harrison, M Taylor