You-Ying Chau
Senior Research Fellow (EPICT)
Address
- Street
-
Queen's Medical Research Institute
47 Little France Crescent
Edinburgh Bioquarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My lab is interested in adipose tissue function, heterogeneity, and their developmental origins. Focusing on adipose progenitors/stem cells (APs), we are investigating the functional heterogeneity APs between different depots and their unique gene expression pathways during normal development as well as in diseased conditions (e.g. obesity). We also study the interactions of APs with their neighbouring cells including vasculatures and immune cells.
Research activities
- Front. Bioeng. Biotechnol. - Tissue Engineering and Regenerative Medicine (Journal)
- PhD viva examiner
- Advanced Science (Journal)
- PeerJ – the Journal of Life & Environmental Sciences (Journal)
- International Journal of Molecular Sciences (Journal)
- BioCell (Journal)
- EMBO Reports (Journal)
- Deciphering adipose tissue heterogeneity
- Deciphering visceral adipose tissue heterogeneity
- Functional Characterisation of ALDH activity in Human Perivascular Cells
- EMBO Journal (Journal)
- EMBO Journal (Journal)
- Cell Reports (Journal)
- BHF Scotland Support Day
- American Journal of Physiology: Cell Physiology (Journal)
- American Journal of Physiology: Cell Physiology (Journal)
- Stem Cells (Journal)
- Science Insights Work Experience Programme 2016 to
- BioMed Research International (Journal)
- PeerJ – the Journal of Life & Environmental Sciences (Journal)
-
Editorial: WT1 in Development and Disease
In:
Frontiers in Cell and Developmental Biology, vol. 10
DOI: https://doi.org/10.3389/fcell.2022.969100
Research output: Contribution to Journal › Editorial (Published) -
Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice
(23 pages)
In:
PLoS Genetics, vol. 18
DOI: https://doi.org/10.1371/journal.pgen.1010240
Research output: Contribution to Journal › Article (Published) -
Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway
In:
Biomedicine and Pharmacotherapy, vol. 144
DOI: https://doi.org/10.1016/j.biopha.2021.112349
Research output: Contribution to Journal › Article (Published) -
Resolving the heterogeneity of diaphragmatic mesenchyme: a novel mouse model of congenital diaphragmatic hernia
In:
Disease Models and Mechanisms, vol. 14
DOI: https://doi.org/10.1242/dmm.046797
Research output: Contribution to Journal › Article (Published) -
Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4
In:
Development, vol. 146
DOI: https://doi.org/10.1242/dev.178723
Research output: Contribution to Journal › Article (Published) -
Empagliflozin Protects HK-2 Cells from High Glucose-Mediated Injuries via a Mitochondrial Mechanism
In:
Cells, vol. 8, pp. 1085
DOI: https://doi.org/10.3390/cells8091085
Research output: Contribution to Journal › Article (Published) -
Fat cell progenitors get singled out
In:
Science, vol. 364, pp. 328-329
DOI: https://doi.org/10.1126/science.aax2967
Research output: Contribution to Journal › Article (Published) -
WT1 Expression in Vessels Varies with Histopathological Grade in Tumour-Bearing and Control Tissue from Patients with Breast Cancer
In:
British Journal of Cancer, vol. 119, pp. 1508–1517
DOI: https://doi.org/10.1038/s41416-018-0317-1
Research output: Contribution to Journal › Article (Published) -
Fifty Shades of White: Understanding Heterogeneity in White Adipose Stem Cells
In:
Adipocyte
DOI: https://doi.org/10.1080/21623945.2017.1372871
Research output: Contribution to Journal › Special issue (E-pub ahead of print) -
Effects of CreERT2, 4-OH Tamoxifen, and Gender on CFU-F Assays
In:
PLoS ONE, vol. 11, pp. e0148105
DOI: https://doi.org/10.1371/journal.pone.0148105
Research output: Contribution to Journal › Article (Published) -
Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio–venous connections
In:
Proceedings of the National Academy of Sciences (PNAS), vol. 113, pp. 656-661
DOI: https://doi.org/10.1073/pnas.1509834113
Research output: Contribution to Journal › Article (Published) -
Isolation and Colony Formation of Murine Bone and Bone Marrow Cells
Research output: › Chapter (Published) -
Isolation and Fluorescence-Activated Cell Sorting of Murine WT1-Expressing Adipocyte Precursor Cells
Research output: › Chapter (Published) -
Homozygous loss-of-function variants in European cosmopolitan and isolate populations
In:
Human Molecular Genetics
DOI: https://doi.org/10.1093/hmg/ddv272
Research output: Contribution to Journal › Article (Published) -
Wt1, the mesothelium and the origins and heterogeneity of visceral fat progenitors
(5 pages)
In:
Adipocyte, vol. 4, pp. 217-221
DOI: https://doi.org/10.4161/21623945.2014.985009
Research output: Contribution to Journal › Comment/debate (Published) -
In vivo imaging of the tumor and its associated microenvironment using combined CARS / 2-photon microscopy
(8 pages)
In:
IntraVital, vol. 4
DOI: https://doi.org/10.1080/21659087.2015.1055430
Research output: Contribution to Journal › Article (Published) -
Wt1 regulates the expression of inhibitory chemokines during heart development
(1 page)
In:
Cardiovascular Research, vol. 103, pp. S57–S94
DOI: https://doi.org/10.1093/cvr/cvu091.3
Research output: Contribution to Journal › Meeting abstract (Published) -
Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source
(9 pages)
In:
Nature Cell Biology, vol. 16, pp. 367-375
DOI: https://doi.org/10.1038/ncb2922
Research output: Contribution to Journal › Article (Published) -
WT1 regulates the expression of inhibitory chemokines during heart development
(13 pages)
In:
Human Molecular Genetics, vol. 22, pp. 5083-5095
DOI: https://doi.org/10.1093/hmg/ddt358
Research output: Contribution to Journal › Article (Published) -
The role of Wt1 in regulating mesenchyme in cancer, development, and tissue homeostasis
(10 pages)
In:
Trends in Genetics, vol. 28, pp. 515-524
DOI: https://doi.org/10.1016/j.tig.2012.04.004
Research output: Contribution to Journal › Literature review (Published)