Tom Chambers
Clinical Lecturer
- Centre for Cardiovascular Science
- Centre for Discovery Brain Science
Contact details
- Email: tom.chambers@ed.ac.uk
Address
- Street
-
Room 171
Hugh Robson Building
15 George Square
EDINBURGH - City
- Post code
- EH8 9XD
Background
I am a SCREDS clinical lecturer. I am currently undertaking an ISSF research leave fellowship before returing to complete the final year of my training in diabetes and endocrinology. I developed an interest in endocrinology as a medical student; during my intercalated MRes year, I studied Wnt induced plasticity in the lactotroph population of the pituitary gland in response to oestrogen.
Following completing core medical training in Manchester, I moved to Edinburgh to undertake a PhD looking at the intergenerational effects of high fat diet exposure focusing on epigentic and transcriptional regulation of the male germ line.
I took up the SCREDS clinical lectureship in 2017 and am developing clincal and basic research to improve our understanding of the recovery and plasticity of the hypothalamus-pituitary-adrenal axis in response to exogenous steroid treatment and withdrawal.
Qualifications
BSc Medical Science
MB ChB
MRes Medical Science
PhD Reproductive health
MRCP
Current research interests
Recovery of the hypothalamus pituitary adrenal (HPA) axis following steroid treatment: 1. Modelling recovery of the HPA axis in vitro (using AtT-20 cell line) and in vivo 2. Plasticity in corticotrophins in response to glucocorticoid 3. Predicting HPA axis recovery in patients following chronic glucocorticoid treatment; developing biomarkers to identify patients at risk of adrenal insufficiencyPast research interests
Lactotroph plasticity/ Wnt signaling in the pituitary. Intergenerational effects of environmental exposures.Current project grants
ISSF3 research leave fellowship August 2019- Feb 2020: Modelling glucocorticoid induced adrenal insufficiency to inform mechanisms
MRC CiC August 2018 - Sept 2019: Development for a novel assay to detect glucocorticoid induced adrenal insufficiency
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Prospective, multicentre study of screening, investigation and management of hyponatraemia after subarachnoid haemorrhage in the UK and Ireland
In:
Stroke and Vascular Neurology
DOI: https://doi.org/10.1136/svn-2022-001583
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Investigation and management of serum sodium after subarachnoid haemorrhage (SaSH): a survey of practice in the United Kingdom and Republic of Ireland
(4 pages)
In:
British Journal of Neurosurgery, pp. 1-4
DOI: https://doi.org/10.1080/02688697.2020.1859460
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Animal models of maternal high fat diet exposure and effects on metabolism in offspring: A meta-regression analysis.
In:
Obesity Reviews
DOI: https://doi.org/10.1111/obr.12524
Research output: Contribution to Journal › Article (E-pub ahead of print) -
High-fat diet disrupts metabolism in two generations of rats in a parent-of-origin specific manner
(11 pages)
In:
Scientific Reports, vol. 6
DOI: https://doi.org/10.1038/srep31857
Research output: Contribution to Journal › Article (Published) -
Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences
In:
Scientific Reports, vol. 6, pp. 19789
DOI: https://doi.org/10.1038/srep19789
Research output: Contribution to Journal › Article (Published) -
The Impact of Male Obesity on Male Reproductive Function
In:
Hormones
DOI: https://doi.org/10.14310/horm.2002.1621
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells
(9 pages)
In:
Proceedings of the National Academy of Sciences (PNAS), vol. 111, pp. E1924-E1932
DOI: https://doi.org/10.1073/pnas.1320735111
Research output: Contribution to Journal › Article (Published) -
Wnt signalling in pituitary development and tumorigenesis.
In:
Endocrine-Related Cancer
DOI: https://doi.org/10.1530/erc-13-0005
Research output: Contribution to Journal › Article (Published) -
Wnt signaling in estrogen-induced lactotroph proliferation.
In:
Journal of Cell Science
DOI: https://doi.org/10.1242/jcs.078642
Research output: Contribution to Journal › Article (Published) -
Real-time analysis of gene regulation by glucocorticoid hormones.
In:
Journal of Endocrinology
DOI: https://doi.org/10.1677/JOE-07-0639
Research output: Contribution to Journal › Article (Published)