Stuart Forbes | The University of Edinburgh

Director, Institute for Regeneration and Repair and Centre for Regenerative Medicine

Centre for Regenerative Medicine
Institute for Regeneration and Repair

Tel: 0131 651 9510 (PA Paul Milligan - 0131 651 9514)
Email: IRR-Director@ed.ac.uk

Street: Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive
City: Edinburgh
Post code: EH16 4UU

Biography

Background

Director Centre for Regenerative Medicine
Director UKRMP The Engineered Cell Environment Hub
Professor of Transplantation and Regenerative Medicine
Consultant Hepatologist Scottish Liver Transplant Unit

Teaching & PhD supervision

Current PhD students supervised

Niya Aleksieva

Jennifer Ann Cartwright

Hannah Esser

Research

Research summary

Liver stem cells and regeneration

Our research concentrates on understanding how the liver regenerates in chronic disease and how this process becomes deranged in the development of liver cancer.

Aims and areas of interest

By understanding what controls liver regeneration in chronic injury our group aims to be able to promote healthy liver regeneration and reduce the formation of liver cirrhosis and cancer. There are 3 linked programs of research:

Basic biology of the hepatic progenitor cell niche.
Cell therapy for liver regeneration.
The Liver Cancer niche in cholangiocarcinoma

Publications

TFEB regulates murine liver cell fate during development and regeneration 18 May 2020 In: Nature Communications
DOI: https://doi.org/10.1038/s41467-020-16300-x
Research output: Contribution to Journal › Article (Published)
Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells 10 Apr 2020 In: Stem Cell Research and Therapy
DOI: https://doi.org/10.1186/s13287-020-01665-z
Research output: Contribution to Journal › Article (Published)
Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose 6 Apr 2020 In: Bmc medical genomics
DOI: https://doi.org/10.1186/s12920-020-0705-2
Research output: Contribution to Journal › Article (E-pub ahead of print)
Regional differences in human biliary tissues and corresponding in vitro derived organoids 29 Mar 2020 In: Hepatology
DOI: https://doi.org/10.1002/hep.31252
Research output: Contribution to Journal › Article (E-pub ahead of print)
Alternatively activated macrophages promotes necrosis resolution following acute liver injury 11 Mar 2020 In: Journal of Hepatology
DOI: https://doi.org/10.1016/j.jhep.2020.02.031
Research output: Contribution to Journal › Article (E-pub ahead of print)
Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes (11 pages) 21 Jan 2020 In: Proceedings of the National Academy of Sciences, vol. 117, pp. 1678-1688
DOI: https://doi.org/10.1073/pnas.1919035117
Research output: Contribution to Journal › Article (Published)
Modulation of biliary cancer chemo-resistance through microRNA-mediated rewiring of the expansion of CD133+ cells 26 Dec 2019 In: Hepatology
DOI: https://doi.org/10.1002/hep.31094
Research output: Contribution to Journal › Article (E-pub ahead of print)
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration 4 Nov 2019 In: Nature Cell Biology
DOI: https://doi.org/10.1038/s41556-019-0402-6
Research output: Contribution to Journal › Article (Published)
Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1 15 Oct 2019 In: Nature Communications
DOI: https://doi.org/10.1038/s41467-019-12701-9
Research output: Contribution to Journal › Article (Published)
Safety profile of autologous macrophage therapy for liver cirrhosis 7 Oct 2019 In: Nature Medicine
DOI: https://doi.org/10.1038/s41591-019-0599-8
Research output: Contribution to Journal › Article (Published)
Quantifying changes in innate immune function following liver transplantation for chronic liver disease Oct 2019 In: HPB, vol. 21
DOI: https://doi.org/10.1016/j.hpb.2019.02.004
Research output: Contribution to Journal › Article (Published)
Peribiliary gland niche participates in biliary tree regeneration in mouse and in human primary sclerosing cholangitis 22 Jul 2019 In: Hepatology
DOI: https://doi.org/10.1002/hep.30871
Research output: Contribution to Journal › Article (E-pub ahead of print)
Macrophages as a Cell-Based Therapy for Liver Disease 26 Jun 2019 In: Seminars in liver disease
DOI: https://doi.org/10.1055/s-0039-1688502
Research output: Contribution to Journal › Article (E-pub ahead of print)
Beneficial Noncancerous Mutations in Liver Disease 28 May 2019 In: Trends in Genetics
DOI: https://doi.org/10.1016/j.tig.2019.05.002
Research output: Contribution to Journal › Article (E-pub ahead of print)
Blended electrospinning with human liver extracellular matrix for engineering new hepatic microenvironments 18 Apr 2019 In: Scientific Reports, vol. 9
DOI: https://doi.org/10.1038/s41598-019-42627-7
Research output: Contribution to Journal › Article (Published)
Biliary-derived hepatocytes in chronic liver injury: Bringing new troops to the battlefield? (3 pages) 10 Apr 2019 In: Journal of Hepatology, vol. 70, pp. 1051-1053
DOI: https://doi.org/10.1016/j.jhep.2019.03.015
Research output: Contribution to Journal › Article (E-pub ahead of print)
Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice Mar 2019 In: Stem cells translational medicine, vol. 8
DOI: https://doi.org/10.1002/sctm.18-0105
Research output: Contribution to Journal › Article (Published)
Hepatocyte-specific β-catenin deletion during severe liver injury provokes cholangiocytes to differentiate into hepatocytes 29 Jan 2019 In: Hepatology, vol. 69
DOI: https://doi.org/10.1002/hep.30270
Research output: Contribution to Journal › Article (Published)
A Novel, Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade 23 Jan 2019 In: Cancer Research
DOI: https://doi.org/10.1158/0008-5472.CAN-18-2244
Research output: Contribution to Journal › Article (E-pub ahead of print)
Cellular plasticity in liver regeneration - spotlight on cholangiocytes 1 Nov 2018 In: Hepatology
DOI: https://doi.org/10.1002/hep.30340
Research output: Contribution to Journal › Article (E-pub ahead of print)

View all 149 publications on Research Explorer

Funders

Collaborators

Prof John Iredale, Centre for Inflammation Research, University of Edinburgh
Dr Luke Boulter, MRC Human Genetics Unit, IGMM, University of Edinburgh
Prof Owen Sansom, The Beatson Insitute, Glasgow
Prof Tania Roskams, KU Leuven, Belgium
Dr Ken Simpson, School of Clinical Sciences, University of Edinburgh
Dr Tim Kendall, Centre for Inflammation Research, University of Edinburgh

This article was published on 6 Aug, 2020