Stuart Forbes | The University of Edinburgh

Director, Institute for Regeneration and Repair and Centre for Regenerative Medicine

Centre for Regenerative Medicine
Institute for Regeneration and Repair

Tel: PA Carolynn Walthew - 0131 651 9637
Email: IRR-Director@ed.ac.uk

Street: Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive
City: Edinburgh
Post code: EH16 4UU

Biography

Background

Director Centre for Regenerative Medicine
Director UKRMP The Engineered Cell Environment Hub
Professor of Transplantation and Regenerative Medicine
Consultant Hepatologist Scottish Liver Transplant Unit

Teaching & PhD supervision

Current PhD students supervised

Niya Aleksieva

Jennifer Ann Cartwright

Hannah Esser

Research

Research summary

Liver stem cells and regeneration

Our research concentrates on understanding how the liver regenerates in chronic disease and how this process becomes deranged in the development of liver cancer.

Aims and areas of interest

By understanding what controls liver regeneration in chronic injury our group aims to be able to promote healthy liver regeneration and reduce the formation of liver cirrhosis and cancer. There are 3 linked programs of research:

Basic biology of the hepatic progenitor cell niche.
Cell therapy for liver regeneration.
The Liver Cancer niche in cholangiocarcinoma

Publications

Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential 13 Apr 2023 In: Cell Genomics, pp. 100301
DOI: https://doi.org/10.1016/j.xgen.2023.100301
Research output: Contribution to Journal › Article (Published)
Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage (16 pages) 7 Dec 2022 In: Science Translational Medicine, vol. 14
DOI: https://doi.org/10.1126/scitranslmed.abj4375
Research output: Contribution to Journal › Article (Published)
Rat liver ECM incorporated into electrospun polycaprolactone scaffolds as a platform for hepatocyte culture Dec 2022 In: Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 110, pp. 2612-2623
DOI: https://doi.org/10.1002/jbm.b.35115
Research output: Contribution to Journal › Article (Published)
Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF (14 pages) Nov 2022 In: Journal of Hepatology, vol. 77, pp. 1325-1338
DOI: https://doi.org/10.1016/j.jhep.2022.07.006
Research output: Contribution to Journal › Article (Published)
PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny 19 Jul 2022 In: Cell Reports, vol. 40
DOI: https://doi.org/10.1016/j.celrep.2022.111114
Research output: Contribution to Journal › Article (Published)
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation 27 May 2022 In: Nature Immunology
DOI: https://doi.org/0.1038/s41590-022-01216-z
Research output: Contribution to Journal › Article (Published)
Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum (17 pages) 10 May 2022 In: Immunology, vol. 166, pp. 458-474
DOI: https://doi.org/10.1111/imm.13483
Research output: Contribution to Journal › Article (Published)
Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence (53 pages) 12 Mar 2022
DOI: https://doi.org/10.1101/2022.03.11.483935
Research output: › Preprint (Published)
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease 3 Mar 2022 In: Cell Stem Cell
DOI: https://doi.org/10.1016/j.stem.2022.02.006
Research output: Contribution to Journal › Article (Published)
Deletion of kif3a in CK19 positive cells leads to primary cilia loss, biliary cell proliferation and cystic liver lesions in TAA-treated mice 10 Jan 2022 In: BBA - Molecular Basis of Disease
DOI: https://doi.org/10.1016/j.bbadis.2021.166335
Research output: Contribution to Journal › Article (Published)
Study Protocol: A multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH) 8 Nov 2021 In: BMJ Open
DOI: https://doi.org/DOI: 10.1136/bmjopen-2021-053190
Research output: Contribution to Journal › Article (Published)
Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation 22 Jun 2021 In: Science Signaling
DOI: https://doi.org/10.1126/scisignal.aay9185
Research output: Contribution to Journal › Article (Published)
Liver regeneration and inflammation: from fundamental science to clinical applications 2 Jun 2021 In: Nature reviews Molecular cell biology
DOI: https://doi.org/10.1038/s41580-021-00373-7
Research output: Contribution to Journal › Review article (E-pub ahead of print)
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure 19 May 2021 In: iScience
DOI: https://doi.org/10.1016/j.isci.2021.102552
Research output: Contribution to Journal › Article (Published)
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair 19 May 2021 In: Science Translational Medicine
DOI: https://doi.org/10.1126/scitranslmed.abb0203
Research output: Contribution to Journal › Article (Published)
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis 16 Apr 2021 In: Journal of Hepatology
DOI: https://doi.org/10.1016/j.jhep.2021.03.029
Research output: Contribution to Journal › Article (Published)
Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells 19 Mar 2021 In: Nature Communications, vol. 12
DOI: https://doi.org/10.1038/s41467-021-21778-0
Research output: Contribution to Journal › Article (Published)
Cellular Senescence in Liver Disease and Regeneration (17 pages) 9 Feb 2021 In: Seminars in liver disease, vol. 41, pp. 50-66
DOI: https://doi.org/10.1055/s-0040-1722262
Research output: Contribution to Journal › Article (E-pub ahead of print)
Response differences of HepG2 and Primary Mouse Hepatocytes to morphological changes in electrospun PCL scaffolds 4 Feb 2021 In: Scientific Reports, vol. 11, pp. 3059
DOI: https://doi.org/10.1038/s41598-021-81761-z
Research output: Contribution to Journal › Article (Published)
Fibroblast Growth Factor 7 Releasing Particles Enhance Islet Engraftment and Improve Metabolic Control Following Islet Transplantation in Mice with Diabetes 11 Jan 2021 In: American Journal of Transplantation
DOI: https://doi.org/10.1111/ajt.16488
Research output: Contribution to Journal › Article (E-pub ahead of print)

View all 176 publications on Research Explorer

Funders

Collaborators

Prof John Iredale, Centre for Inflammation Research, University of Edinburgh
Dr Luke Boulter, MRC Human Genetics Unit, IGMM, University of Edinburgh
Prof Owen Sansom, The Beatson Insitute, Glasgow
Prof Tania Roskams, KU Leuven, Belgium
Dr Ken Simpson, School of Clinical Sciences, University of Edinburgh
Dr Tim Kendall, Centre for Inflammation Research, University of Edinburgh

This article was published on 24 Sep, 2023