Stuart Forbes
Director, Institute for Regeneration and Repair and Centre for Regenerative Medicine
- Centre for Regenerative Medicine
- Institute for Regeneration and Repair
Contact details
Address
- Street
-
Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive - City
- Edinburgh
- Post code
- EH16 4UU
Background
- Director Centre for Regenerative Medicine
- Director UKRMP The Engineered Cell Environment Hub
- Professor of Transplantation and Regenerative Medicine
- Consultant Hepatologist Scottish Liver Transplant Unit
Current PhD students supervised
Niya Aleksieva
Jennifer Ann Cartwright
Hannah Esser
Research summary
Liver stem cells and regeneration
Our research concentrates on understanding how the liver regenerates in chronic disease and how this process becomes deranged in the development of liver cancer.
Aims and areas of interest
By understanding what controls liver regeneration in chronic injury our group aims to be able to promote healthy liver regeneration and reduce the formation of liver cirrhosis and cancer. There are 3 linked programs of research:
- Basic biology of the hepatic progenitor cell niche.
- Cell therapy for liver regeneration.
- The Liver Cancer niche in cholangiocarcinoma
-
TFEB regulates murine liver cell fate during development and regeneration
In:
Nature Communications
DOI: https://doi.org/10.1038/s41467-020-16300-x
Contribution to Journal › Article (Published) -
Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells
In:
Stem Cell Research and Therapy
DOI: https://doi.org/10.1186/s13287-020-01665-z
Contribution to Journal › Article (Published) -
Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose
In:
Bmc medical genomics
DOI: https://doi.org/10.1186/s12920-020-0705-2
Contribution to Journal › Article (E-pub ahead of print) -
Regional differences in human biliary tissues and corresponding in vitro derived organoids
In:
Hepatology
DOI: https://doi.org/10.1002/hep.31252
Contribution to Journal › Article (Published) -
Alternatively activated macrophages promotes necrosis resolution following acute liver injury
In:
Journal of Hepatology
DOI: https://doi.org/10.1016/j.jhep.2020.02.031
Contribution to Journal › Article (E-pub ahead of print) -
Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes
(11 pages)
In:
Proceedings of the National Academy of Sciences, vol. 117, pp. 1678-1688
DOI: https://doi.org/10.1073/pnas.1919035117
Contribution to Journal › Article (Published) -
Modulation of biliary cancer chemo-resistance through microRNA-mediated rewiring of the expansion of CD133+ cells
In:
Hepatology
DOI: https://doi.org/10.1002/hep.31094
Contribution to Journal › Article (E-pub ahead of print) -
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration
In:
Nature Cell Biology
DOI: https://doi.org/10.1038/s41556-019-0402-6
Contribution to Journal › Article (Published) -
Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1
In:
Nature Communications
DOI: https://doi.org/10.1038/s41467-019-12701-9
Contribution to Journal › Article (Published) -
Safety profile of autologous macrophage therapy for liver cirrhosis
In:
Nature Medicine
DOI: https://doi.org/10.1038/s41591-019-0599-8
Contribution to Journal › Article (Published) -
Quantifying changes in innate immune function following liver transplantation for chronic liver disease
In:
HPB, vol. 21
DOI: https://doi.org/10.1016/j.hpb.2019.02.004
Contribution to Journal › Article (Published) -
Peribiliary gland niche participates in biliary tree regeneration in mouse and in human primary sclerosing cholangitis
In:
Hepatology
DOI: https://doi.org/10.1002/hep.30871
Contribution to Journal › Article (E-pub ahead of print) -
Macrophages as a Cell-Based Therapy for Liver Disease
In:
Seminars in liver disease
DOI: https://doi.org/10.1055/s-0039-1688502
Contribution to Journal › Article (E-pub ahead of print) -
Beneficial Noncancerous Mutations in Liver Disease
In:
Trends in Genetics
DOI: https://doi.org/10.1016/j.tig.2019.05.002
Contribution to Journal › Article (E-pub ahead of print) -
Blended electrospinning with human liver extracellular matrix for engineering new hepatic microenvironments
In:
Scientific Reports, vol. 9
DOI: https://doi.org/10.1038/s41598-019-42627-7
Contribution to Journal › Article (Published) -
Biliary-derived hepatocytes in chronic liver injury
(3 pages)
In:
Journal of Hepatology, vol. 70, pp. 1051-1053
DOI: https://doi.org/10.1016/j.jhep.2019.03.015
Contribution to Journal › Article (E-pub ahead of print) -
Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice
In:
Stem cells translational medicine, vol. 8
DOI: https://doi.org/10.1002/sctm.18-0105
Contribution to Journal › Article (Published) -
Hepatocyte-specific β-catenin deletion during severe liver injury provokes cholangiocytes to differentiate into hepatocytes
In:
Hepatology, vol. 69
DOI: https://doi.org/10.1002/hep.30270
Contribution to Journal › Article (Published) -
A Novel, Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade
In:
Cancer Research
DOI: https://doi.org/10.1158/0008-5472.CAN-18-2244
Contribution to Journal › Article (E-pub ahead of print) -
Cellular plasticity in liver regeneration - spotlight on cholangiocytes
In:
Hepatology
DOI: https://doi.org/10.1002/hep.30340
Contribution to Journal › Article (E-pub ahead of print)
- Prof John Iredale, Centre for Inflammation Research, University of Edinburgh
- Dr Luke Boulter, MRC Human Genetics Unit, IGMM, University of Edinburgh
- Prof Owen Sansom, The Beatson Insitute, Glasgow
- Prof Tania Roskams, KU Leuven, Belgium
- Dr Ken Simpson, School of Clinical Sciences, University of Edinburgh
- Dr Tim Kendall, Centre for Inflammation Research, University of Edinburgh