Stuart Forbes | The University of Edinburgh

Director, Institute for Regeneration and Repair and Centre for Regenerative Medicine

Centre for Regenerative Medicine
Institute for Regeneration and Repair

Tel: 0131 651 9510 (PA Paul Milligan - 0131 651 9514)
Email: IRR-Director@ed.ac.uk

Street: Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive
City: Edinburgh
Post code: EH16 4UU

Biography

Background

Director Centre for Regenerative Medicine
Director UKRMP The Engineered Cell Environment Hub
Professor of Transplantation and Regenerative Medicine
Consultant Hepatologist Scottish Liver Transplant Unit

Teaching & PhD supervision

Current PhD students supervised

Niya Aleksieva

Jennifer Ann Cartwright

Hannah Esser

Research

Research summary

Liver stem cells and regeneration

Our research concentrates on understanding how the liver regenerates in chronic disease and how this process becomes deranged in the development of liver cancer.

Aims and areas of interest

By understanding what controls liver regeneration in chronic injury our group aims to be able to promote healthy liver regeneration and reduce the formation of liver cirrhosis and cancer. There are 3 linked programs of research:

Basic biology of the hepatic progenitor cell niche.
Cell therapy for liver regeneration.
The Liver Cancer niche in cholangiocarcinoma

Publications

Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation 22 Jun 2021 In: Science Signaling
DOI: https://doi.org/10.1126/scisignal.aay9185
Research output: Contribution to Journal › Article (Published)
Liver regeneration and inflammation: from fundamental science to clinical applications 2 Jun 2021 In: Nature reviews Molecular cell biology
DOI: https://doi.org/10.1038/s41580-021-00373-7
Research output: Contribution to Journal › Review article (E-pub ahead of print)
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure 19 May 2021 In: iScience
DOI: https://doi.org/10.1016/j.isci.2021.102552
Research output: Contribution to Journal › Article (Published)
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair 19 May 2021 In: Science Translational Medicine
DOI: https://doi.org/10.1126/scitranslmed.abb0203
Research output: Contribution to Journal › Article (Published)
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis 16 Apr 2021 In: Journal of Hepatology
DOI: https://doi.org/10.1016/j.jhep.2021.03.029
Research output: Contribution to Journal › Article (Published)
Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells 19 Mar 2021 In: Nature Communications, vol. 12
DOI: https://doi.org/10.1038/s41467-021-21778-0
Research output: Contribution to Journal › Article (Published)
Cellular Senescence in Liver Disease and Regeneration (17 pages) 9 Feb 2021 In: Seminars in liver disease, vol. 41, pp. 50-66
DOI: https://doi.org/10.1055/s-0040-1722262
Research output: Contribution to Journal › Article (E-pub ahead of print)
Response differences of HepG2 and Primary Mouse Hepatocytes to morphological changes in electrospun PCL scaffolds 4 Feb 2021 In: Scientific Reports, vol. 11, pp. 3059
DOI: https://doi.org/10.1038/s41598-021-81761-z
Research output: Contribution to Journal › Article (Published)
Fibroblast Growth Factor 7 Releasing Particles Enhance Islet Engraftment and Improve Metabolic Control Following Islet Transplantation in Mice with Diabetes 11 Jan 2021 In: American Journal of Transplantation
DOI: https://doi.org/10.1111/ajt.16488
Research output: Contribution to Journal › Article (E-pub ahead of print)
Non-invasive detection of ischemic vascular damage in a pig model of liver donation after circulatory death 8 Jan 2021 In: Hepatology
DOI: https://doi.org/10.1002/hep.31701
Research output: Contribution to Journal › Article (E-pub ahead of print)
A Blueprint for Translational Regenerative Medicine 2 Dec 2020 In: Science Translational Medicine
DOI: https://doi.org/10.1126/scitranslmed.aaz2253
Research output: Contribution to Journal › Article (Published)
TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression. 19 Nov 2020 In: Journal of Hepatology, vol. n/a, pp. 1-72
DOI: https://doi.org/10.1016/j.jhep.2020.11.018
Research output: Contribution to Journal › Article (E-pub ahead of print)
Epithelial Plasticity during Liver Injury and Regeneration (17 pages) 1 Oct 2020 In: Cell Stem Cell, vol. 27, pp. 557-573
DOI: https://doi.org/10.1016/j.stem.2020.08.016
Research output: Contribution to Journal › Review article (Published)
Cell Therapy for Advanced Liver Diseases: Repair or Rebuild 22 Sep 2020 In: Journal of Hepatology
DOI: https://doi.org/10.1016/j.jhep.2020.09.014
Research output: Contribution to Journal › Review article (E-pub ahead of print)
TFEB regulates murine liver cell fate during development and regeneration 18 May 2020 In: Nature Communications, vol. 11
DOI: https://doi.org/10.1038/s41467-020-16300-x
Research output: Contribution to Journal › Article (Published)
Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells 10 Apr 2020 In: Stem Cell Research and Therapy
DOI: https://doi.org/10.1186/s13287-020-01665-z
Research output: Contribution to Journal › Article (Published)
Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose 6 Apr 2020 In: BMC Medical Genomics, vol. 13
DOI: https://doi.org/10.1186/s12920-020-0705-2
Research output: Contribution to Journal › Article (Published)
Regional differences in human biliary tissues and corresponding in vitro derived organoids 29 Mar 2020 In: Hepatology
DOI: https://doi.org/10.1002/hep.31252
Research output: Contribution to Journal › Article (E-pub ahead of print)
Alternatively activated macrophages promotes necrosis resolution following acute liver injury (12 pages) 11 Mar 2020 In: Journal of Hepatology, vol. 73, pp. 349-360
DOI: https://doi.org/10.1016/j.jhep.2020.02.031
Research output: Contribution to Journal › Article (E-pub ahead of print)
Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes (11 pages) 21 Jan 2020 In: Proceedings of the National Academy of Sciences, vol. 117, pp. 1678-1688
DOI: https://doi.org/10.1073/pnas.1919035117
Research output: Contribution to Journal › Article (Published)

View all 164 publications on Research Explorer

Funders

Collaborators

Prof John Iredale, Centre for Inflammation Research, University of Edinburgh
Dr Luke Boulter, MRC Human Genetics Unit, IGMM, University of Edinburgh
Prof Owen Sansom, The Beatson Insitute, Glasgow
Prof Tania Roskams, KU Leuven, Belgium
Dr Ken Simpson, School of Clinical Sciences, University of Edinburgh
Dr Tim Kendall, Centre for Inflammation Research, University of Edinburgh

This article was published on 24 Jan, 2022