Stuart Forbes
Director, Institute for Regeneration and Repair and Centre for Regenerative Medicine

- Centre for Regenerative Medicine
- Institute for Regeneration and Repair
Contact details
Address
- Street
-
Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive - City
- Edinburgh
- Post code
- EH16 4UU
Background
- Director Centre for Regenerative Medicine
- Director UKRMP The Engineered Cell Environment Hub
- Professor of Transplantation and Regenerative Medicine
- Consultant Hepatologist Scottish Liver Transplant Unit
Current PhD students supervised
Niya Aleksieva
Jennifer Ann Cartwright
Hannah Esser
Research summary
Liver stem cells and regeneration
Our research concentrates on understanding how the liver regenerates in chronic disease and how this process becomes deranged in the development of liver cancer.
Aims and areas of interest
By understanding what controls liver regeneration in chronic injury our group aims to be able to promote healthy liver regeneration and reduce the formation of liver cirrhosis and cancer. There are 3 linked programs of research:
- Basic biology of the hepatic progenitor cell niche.
- Cell therapy for liver regeneration.
- The Liver Cancer niche in cholangiocarcinoma
-
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
In:
Nature Immunology
Research output: Contribution to Journal › Article (Accepted/In press) -
Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence
DOI: https://doi.org/10.1101/2022.03.11.483935
Research output: › Other contribution (Published) -
Deletion of kif3a in CK19 positive cells leads to primary cilia loss, biliary cell proliferation and cystic liver lesions in TAA-treated mice
In:
BBA - Molecular Basis of Disease
DOI: https://doi.org/10.1016/j.bbadis.2021.166335
Research output: Contribution to Journal › Article (Published) -
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease
In:
Cell Stem Cell
Research output: Contribution to Journal › Article (Accepted/In press) -
Study Protocol: A multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH)
In:
BMJ Open
DOI: https://doi.org/DOI: 10.1136/bmjopen-2021-053190
Research output: Contribution to Journal › Article (Published) -
Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation
In:
Science Signaling
DOI: https://doi.org/10.1126/scisignal.aay9185
Research output: Contribution to Journal › Article (Published) -
Liver regeneration and inflammation: from fundamental science to clinical applications
In:
Nature reviews Molecular cell biology
DOI: https://doi.org/10.1038/s41580-021-00373-7
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure
In:
iScience
DOI: https://doi.org/10.1016/j.isci.2021.102552
Research output: Contribution to Journal › Article (Published) -
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair
In:
Science Translational Medicine
DOI: https://doi.org/10.1126/scitranslmed.abb0203
Research output: Contribution to Journal › Article (Published) -
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis
In:
Journal of Hepatology
DOI: https://doi.org/10.1016/j.jhep.2021.03.029
Research output: Contribution to Journal › Article (Published) -
Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells
In:
Nature Communications, vol. 12
DOI: https://doi.org/10.1038/s41467-021-21778-0
Research output: Contribution to Journal › Article (Published) -
Cellular Senescence in Liver Disease and Regeneration
(17 pages)
In:
Seminars in liver disease, vol. 41, pp. 50-66
DOI: https://doi.org/10.1055/s-0040-1722262
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Response differences of HepG2 and Primary Mouse Hepatocytes to morphological changes in electrospun PCL scaffolds
In:
Scientific Reports, vol. 11, pp. 3059
DOI: https://doi.org/10.1038/s41598-021-81761-z
Research output: Contribution to Journal › Article (Published) -
Fibroblast Growth Factor 7 Releasing Particles Enhance Islet Engraftment and Improve Metabolic Control Following Islet Transplantation in Mice with Diabetes
In:
American Journal of Transplantation
DOI: https://doi.org/10.1111/ajt.16488
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Non-invasive detection of ischemic vascular damage in a pig model of liver donation after circulatory death
In:
Hepatology
DOI: https://doi.org/10.1002/hep.31701
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Noninvasive Detection of Ischemic Vascular Damage in a Pig Model of Liver Donation After Circulatory Death
In:
Hepatology, vol. 74, pp. 428-443
DOI: https://doi.org/10.1002/hep.31701
Research output: Contribution to Journal › Article (Published) -
A Blueprint for Translational Regenerative Medicine
In:
Science Translational Medicine
DOI: https://doi.org/10.1126/scitranslmed.aaz2253
Research output: Contribution to Journal › Article (Published) -
TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression.
In:
Journal of Hepatology, vol. n/a, pp. 1-72
DOI: https://doi.org/10.1016/j.jhep.2020.11.018
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Epithelial Plasticity during Liver Injury and Regeneration
(17 pages)
In:
Cell Stem Cell, vol. 27, pp. 557-573
DOI: https://doi.org/10.1016/j.stem.2020.08.016
Research output: Contribution to Journal › Review article (Published) -
Cell Therapy for Advanced Liver Diseases: Repair or Rebuild
In:
Journal of Hepatology
DOI: https://doi.org/10.1016/j.jhep.2020.09.014
Research output: Contribution to Journal › Review article (E-pub ahead of print)
- Prof John Iredale, Centre for Inflammation Research, University of Edinburgh
- Dr Luke Boulter, MRC Human Genetics Unit, IGMM, University of Edinburgh
- Prof Owen Sansom, The Beatson Insitute, Glasgow
- Prof Tania Roskams, KU Leuven, Belgium
- Dr Ken Simpson, School of Clinical Sciences, University of Edinburgh
- Dr Tim Kendall, Centre for Inflammation Research, University of Edinburgh