Roger Brown
Senior Clinical Lecturer

Address
- Street
-
Centre for Cardiovascular Science,
The Queen's Medical Research Institute,
Edinburgh BioQuarter,
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
I have longstanding interests in endocrine disorders and the origin of hypertension, especially renal and endocrine mechanisms. I have been involved in characterising pathways involved in these mechanisms (e.g. identifying and cloning 11B-Hydroxysteroid dehydrogenase 2 involved in corticosteroid related effects on blood pressure and WNK Kinase pathways involved in renal blood pressure and electrolyte handling). I am a Consultant Endocrinologist and Hypertension Specialist, with clinics looking after patients with a wide range of hormonal and hypertensive problems, which has led to interests in imaging characteristics and markers of medication use which may link to outcomes. I have become involved in work with families with rare endocrine disorders, national studies of rare endocrine tumours affecting blood pressure and studies of anti-hypertensive use.
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Nonadherence to antihypertensive medications is related to pill burden in apparent treatment-resistant hypertensive individuals
In:
Journal of Hypertension
DOI: https://doi.org/10.1097/HJH.0000000000002398
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Naturally too sympathetic to a bad diet?
(3 pages)
In:
Journal of the American Society of Nephrology, vol. 19, pp. 420-2
DOI: https://doi.org/10.1681/ASN.2008010040
Research output: Contribution to Journal › Editorial (Published) -
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo
(12 pages)
In:
Journal of the American Society of Nephrology, vol. 17, pp. 2402-13
DOI: https://doi.org/10.1681/ASN.2005111197
Research output: Contribution to Journal › Article (Published) -
Ontogeny of glucocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development
(12 pages)
In:
Journal of Endocrinology, vol. 181, pp. 105-116
Research output: Contribution to Journal › Article (Published) -
Modelling hypertension induced by aldosterone excess and increased dietary sodium.
(1 page)
In:
Journal of the American Society of Nephrology, vol. 14, pp. 521A-521A
Research output: Contribution to Journal › Article (Published) -
Mobilization of pluripotent Haematopoietic Stem Cells occurs in alcoholic hepatitis and is associated with an improved clinical outcome.
(2 pages)
In:
Hepatology, vol. 38, pp. 284A-285A
Research output: Contribution to Journal › Meeting abstract (Published) -
Sgk1 gene expression in kidney and its regulation by aldosterone: Spatio-temporal heterogeneity and quantitative analysis
(9 pages)
In:
Journal of the American Society of Nephrology, vol. 13, pp. 1190-1198
DOI: https://doi.org/10.1097/01.ASN.0000013702.73570.3B
Research output: Contribution to Journal › Article (Published) -
Corticosteroid regulation of amiloride-sensitive sodium-channel subunit mRNA expression in mouse kidney
(13 pages)
In:
Journal of Endocrinology, vol. 165, pp. 25-37
Research output: Contribution to Journal › Article (Published) -
Hypertension in mice lacking 11 beta-hydroxysteroid dehydrogenase type 2
(7 pages)
In:
Journal of Clinical Investigation, vol. 103, pp. 683-689
DOI: https://doi.org/10.1172/JCI4445
Research output: Contribution to Journal › Article (Published) -
Hypertension and renal abnormalities caused by targeted inactivation of 11 beta hydroxysteroid dehydrogenase type 2
(1 page)
In:
Journal of Pathology, vol. 187, pp. 11A-11A
Research output: Contribution to Journal › Article (Published) -
Hypertension in mice caused by inactivation of 11 beta-hydroxysteroid dehydrogenase type 2
(1 page)
In:
Journal of Hypertension, vol. 16, pp. S5-S5
Research output: Contribution to Journal › Article (Published) -
Distinct ontogeny of glucocorticoid and mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase types I and II mRNAs in the fetal rat brain suggest a complex control of glucocorticoid actions
(11 pages)
In:
Journal of Neuroscience, vol. 18, pp. 2570-2580
Research output: Contribution to Journal › Article (Published) -
Tissue-specific messenger ribonucleic acid expression of 11 beta-hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor within rat placenta suggests exquisite local control of glucocorticoid action
(7 pages)
In:
Endocrinology, vol. 139, pp. 1517-1523
Research output: Contribution to Journal › Article (Published) -
11 beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress
(6 pages)
In:
Proceedings of the National Academy of Sciences (PNAS), vol. 94, pp. 14924-14929
Research output: Contribution to Journal › Article (Published) -
Purification of 11 beta-hydroxysteroid dehydrogenase type 2 from human placenta utilizing a novel affinity labelling technique
(9 pages)
In:
Biochemical Journal, vol. 313, pp. 997-1005
Research output: Contribution to Journal › Article (Published) -
Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2
(11 pages)
In:
Biochemical Journal, vol. 313, pp. 1007-1017
Research output: Contribution to Journal › Article (Published) -
The ontogeny of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development.
(4 pages)
In:
Endocrinology, vol. 137, pp. 794-797
Research output: Contribution to Journal › Article (Published)