Dr Riccardo Marioni
- Centre for Genomic and Experimental Medicine
- MRC Institute of Genetics and Molecular Medicine
Contact details
- Email: Riccardo.Marioni@ed.ac.uk
Address
- Street
-
Centre for Genomic & Experimental Medicine MRC Institute of Genetics & Molecular Medicine University of Edinburgh Western General Hospital Crewe Road South
- City
- Edinburgh
- Post code
- EH4 2XU
Background
I am a University of Edinburgh Chancellor's Fellow based in the Centre for Genomic and Experimental Medicine and the Centre for Cognitive Ageing and Cognitive Epidemiology.
My fellowship was part-funded by the University of Queensland where I was an Adjunct Research Fellow between 2013-2016.
My postdoctoral research included a year at the Department of Public Health and Primary Care at the University of Cambridge (2009-2010). Whilst there, I was awarded an Alzheimer's Research UK fellowship (2010-2013) in conjunction with the Medical Research Council Biostatistics Unit, Cambridge, the Department of Biostatistics, INSERM U897, Bordeaux and the University of Edinburgh Department of Psychology, to develop and apply longitudinal statistical methods for cognitive ageing.
Qualifications
Academic Qualifications
-
Bachelor
- 2005, Bachelor of Science, University of Aberdeen
- Master
- 2006, Master of Science, University of Edinburgh
- Doctorate
- 2009, Doctor of Philosophy, PhD, University of Edinburgh
Research summary
My group’s primary research goal is to use computational models to understand the molecular mechanisms that underlie Alzheimer’s disease and to enhance prediction of the disease. We have a passion for research into ageing and, in particular, examining the genetic and environmental contributions to health, cognitive ageing, and dementia. Our work is at the intersection of the biomedical and social sciences.
We work with data from large, population-based cohorts including Generation Scotland, UK Biobank, and the Lothian Birth Cohorts of 1921 and 1936.
Research activities
Current project grants
Omics prediction of Alzheimer’s disease.
Alzheimer's Research UK Major Project Grant (ARUK-PG2017B-10)
Role: Principal Investigator
Duration: 01/10/17 - 30/09/20
Award: £166,833
A non-invasive mouse DNA methylation age predictor for longitudinal studies.
Centre for Cognitive Ageing and Cognitive Epidemiology Pilot Grant
Role: Principal Investigator
Duration: 01/10/17 - 31/12/18
Award: £5,404
Past project grants
Epigenetic, structural brain MRI, and cognitive changes over the eighth decade.
Gertrude Winifred Gear Fund, University of Edinburgh College of Medicine and Veterinary Medicine & Wellcome Trust - University of Edinburgh Institutional Strategic Support Fund
Role: Principal Investigator
Duration: 03/01/16 - 12/01/16
Award: £108,800
INTERpreting epigenetic signatures in STudies of Early Life Adversity (InterStELA).
ESRC/BBSRC Network Grant (ES/N000382/1)
Role: Co-Investigator, PI: Laura Howe, University of Bristol
Duration: 10/01/2015 - 09/30/17
Award: £199,513
Epigenetics: Environment, Embodiment and Equality (E4).
ESRC/BBSRC Project Grant (ES/N000498/1)
Role: Co-Investigator, PI: Caroline Relton, University of Bristol
Duration: 10/01/2015 - 30/09/18
Award: £667,460
The epiGenetIcs Leads to aGe-relAted diseases (GILGA-mesh) Network.
NIH: U34 Research Grant (AG051425-01)
Role: Co-Investigator, PI: Steve Horvath, UCLA
Duration: 10/01/2015 - 30/09/18
Award: $953,566
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Correction: GWAS on family history of Alzheimer’s disease
In:
Translational Psychiatry, vol. 9, no. 1
DOI: https://doi.org/10.1038/s41398-019-0498-2
Contribution to journal › Article (Published) -
Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD
In:
EBioMedicine, vol. 43, pp. 576-586
DOI: https://doi.org/10.1016/j.ebiom.2019.03.072
Contribution to journal › Article (Published) -
Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936
In:
Translational Psychiatry
Contribution to journal › Article (Accepted/In press) -
Age-related clonal haematopoiesis is associated with increased epigenetic age
In:
Current Biology
Contribution to journal › Article (Accepted/In press) -
Author Correction : Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
In:
Nature Communications, vol. 10, no. 1, pp. 2068
DOI: https://doi.org/10.1038/s41467-019-10160-w
Contribution to journal › Article (Published) -
Publisher Correction : Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
In:
Nature Communications, vol. 10, no. 1, pp. 2069
DOI: https://doi.org/10.1038/s41467-019-10155-7
Contribution to journal › Article (Published) -
Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
In:
Nature Human Behaviour, vol. 3, no. 5, pp. 513-525
DOI: https://doi.org/10.1038/s41562-019-0566-x
Contribution to journal › Article (Published) -
Examining the Impact of Imputation Errors on Fine-Mapping Using DNA Methylation QTL as a Model Trait
In:
Genetics
DOI: https://doi.org/10.1534/genetics.118.301861
Contribution to journal › Article (E-pub ahead of print) -
An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort
In:
International Journal of Obesity
DOI: https://doi.org/10.1038/s41366-018-0262-3
Contribution to journal › Article (Published) -
Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
In:
Nature Communications, vol. 10
DOI: https://doi.org/10.1038/s41467-019-09301-y
Contribution to journal › Article (E-pub ahead of print)