Dr Riccardo Marioni

Centre for Genomic and Experimental Medicine
MRC Institute of Genetics and Molecular Medicine

Email: Riccardo.Marioni@ed.ac.uk

Street: Centre for Genomic & Experimental Medicine MRC Institute of Genetics & Molecular Medicine University of Edinburgh Western General Hospital Crewe Road South
City: Edinburgh
Post code: EH4 2XU

Biography

Background

I am a University of Edinburgh Chancellor's Fellow based in the Centre for Genomic and Experimental Medicine and the Centre for Cognitive Ageing and Cognitive Epidemiology.

My fellowship was part-funded by the University of Queensland where I was an Adjunct Research Fellow between 2013-2016.

My postdoctoral research included a year at the Department of Public Health and Primary Care at the University of Cambridge (2009-2010). Whilst there, I was awarded an Alzheimer's Research UK fellowship (2010-2013) in conjunction with the Medical Research Council Biostatistics Unit, Cambridge, the Department of Biostatistics, INSERM U897, Bordeaux and the University of Edinburgh Department of Psychology, to develop and apply longitudinal statistical methods for cognitive ageing.

Qualifications

Academic Qualifications

Bachelor
- 2005, Bachelor of Science, University of Aberdeen
Master
- 2006, Master of Science, University of Edinburgh
Doctorate
- 2009, Doctor of Philosophy, PhD, University of Edinburgh

Research

Research summary

My group’s primary research goal is to use computational models to understand the molecular mechanisms that underlie Alzheimer’s disease and to enhance prediction of the disease. We have a passion for research into ageing and, in particular, examining the genetic and environmental contributions to health, cognitive ageing, and dementia. Our work is at the intersection of the biomedical and social sciences.

We work with data from large, population-based cohorts including Generation Scotland, UK Biobank, and the Lothian Birth Cohorts of 1921 and 1936.

Projects

Current project grants

Omics prediction of Alzheimer’s disease.
Alzheimer's Research UK Major Project Grant (ARUK-PG2017B-10)
Role: Principal Investigator
Duration: 01/10/17 - 30/09/20
Award: £166,833

A non-invasive mouse DNA methylation age predictor for longitudinal studies.
Centre for Cognitive Ageing and Cognitive Epidemiology Pilot Grant
Role: Principal Investigator
Duration: 01/10/17 - 31/12/18
Award: £5,404

Past project grants

Epigenetic, structural brain MRI, and cognitive changes over the eighth decade.
Gertrude Winifred Gear Fund, University of Edinburgh College of Medicine and Veterinary Medicine & Wellcome Trust - University of Edinburgh Institutional Strategic Support Fund
Role: Principal Investigator
Duration: 03/01/16 - 12/01/16
Award: £108,800

INTERpreting epigenetic signatures in STudies of Early Life Adversity (InterStELA).
ESRC/BBSRC Network Grant (ES/N000382/1)
Role: Co-Investigator, PI: Laura Howe, University of Bristol
Duration: 10/01/2015 - 09/30/17
Award: £199,513

Epigenetics: Environment, Embodiment and Equality (E4).
ESRC/BBSRC Project Grant (ES/N000498/1)
Role: Co-Investigator, PI: Caroline Relton, University of Bristol
Duration: 10/01/2015 - 30/09/18
Award: £667,460

The epiGenetIcs Leads to aGe-relAted diseases (GILGA-mesh) Network.
NIH: U34 Research Grant (AG051425-01)
Role: Co-Investigator, PI: Steve Horvath, UCLA
Duration: 10/01/2015 - 30/09/18
Award: $953,566

Publications

Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder 19 Nov 2020 In: Brain, Behavior, and Immunity
DOI: https://doi.org/10.1016/j.bbi.2020.11.024
Research output: Contribution to Journal › Article (E-pub ahead of print)
Birth weight associations with DNA methylation differences in an adult population 20 Oct 2020 In: Epigenetics
DOI: https://doi.org/10.1080/15592294.2020.1827713
Research output: Contribution to Journal › Article (E-pub ahead of print)
Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture 23 Sep 2020 In: Nature Communications
DOI: https://doi.org/10.1038/s41467-020-18534-1
Research output: Contribution to Journal › Article (E-pub ahead of print)
Epigenome-wide analyses identify DNA methylation signatures of dementia risk 10 Aug 2020 In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Research output: Contribution to Journal › Article (E-pub ahead of print)
Epigenetic measures of ageing predict prevalence and incidence of leading causes of death and disease burden 14 Jul 2020 In: Clinical Epigenetics
Research output: Contribution to Journal › Article (Accepted/In press)
Characterisation of an inflammation-related epigenetic score and its association with cognitive ability 9 Jul 2020 In: Clinical Epigenetics
Research output: Contribution to Journal › Article (Accepted/In press)
Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults 8 Jul 2020 In: Genome Medicine
DOI: https://doi.org/10.1186/s13073-020-00754-1
Research output: Contribution to Journal › Article (Published)
Epigenetic prediction of major depressive disorder 10 Jun 2020 In: Molecular Psychiatry
DOI: https://doi.org/10.1038/s41380-020-0808-3
Research output: Contribution to Journal › Article (E-pub ahead of print)
Bayesian reassessment of the epigenetic architecture of complex traits 8 Jun 2020 In: Nature Communications
DOI: https://doi.org/10.1038/s41467-020-16520-1
Research output: Contribution to Journal › Article (Published)
Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection 2 Jun 2020 In: Cell Systems
DOI: https://doi.org/10.1016/j.cels.2020.05.012
Research output: Contribution to Journal › Article (E-pub ahead of print)

View all 162 publications on Research Explorer

This article was published on 13 Jan, 2021