Paul Sharp
Contact details
- Tel: +44 (0)131 651 3684
- Email: paul.sharp@ed.ac.uk
Address
- Street
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Rm. G61C, Ashworth Building
- City
- Post code
Background
1982 Ph.D., Department of Genetics, University of Edinburgh
1982-1992 Lecturer in Genetics, Trinity College, University of Dublin
1985-1987 Visiting Assistant Professor, University of Texas at Houston
1992-1993 Associate Professor of Genetics, Trinity College, University of Dublin
1992 Elected to membership, European Molecular Biology Organization
1993-2007 Professor of Genetics, University of Nottingham
1993 Elected to membership, Royal Irish Academy
2008 President, Society for Molecular Biology and Evolution
2007-Present Professor of Genetics, University of Edinburgh
Postgraduate teaching
MSc in Quantitative Genetics and Genome Analysis
Research summary
Evolution of viruses, and evolution of bacteria. My research employs computer analyses of nucleotide and protein sequence data to address a range of evolutionary questions.
Viral evolution: what are the origins of human viruses, and what factors influence their genetic diversity? A particular focus has been the origins and evolution of AIDS viruses.
Bacterial evolution: what do bacterial genome sequences tell us about evolution? Two particular areas involve the evolution of synonymous codon usage bias, and the evolution of repetitive sequence families.
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Malaria-driven adaptation of MHC class I in wild bonobo populations
(11 pages)
In:
Nature Communications, vol. 14
DOI: https://doi.org/10.1038/s41467-023-36623-9
Research output: Contribution to Journal › Article (Published) -
The African origin of plasmodium vivax
(6 pages)
In:
FEMS microbiology reviews, vol. 46
DOI: https://doi.org/10.1093/femsre/fuac015
Research output: Contribution to Journal › Letter (Published) -
Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes
(12 pages)
In:
Nature Communications, vol. 13
DOI: https://doi.org/10.1038/s41467-022-29306-4
Research output: Contribution to Journal › Article (Published) -
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses
In:
Proceedings of the National Academy of Sciences (PNAS), vol. 118
DOI: https://doi.org/10.1073/pnas.2025914118
Research output: Contribution to Journal › Article (Published) -
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption
(89 pages)
In:
Science Translational Medicine, vol. 13
DOI: https://doi.org/10.1126/SCITRANSLMED.ABD8179
Research output: Contribution to Journal › Article (Published) -
Ape origins of human malaria
In:
Annual review of microbiology, vol. 74
DOI: https://doi.org/10.1146/annurev-micro-020518-115628
Research output: Contribution to Journal › Article (Published) -
Ancient introgression between two ape malaria parasite species
In:
Genome Biology and Evolution, vol. 11, pp. 3269-3274
DOI: https://doi.org/10.1093/gbe/evz244
Research output: Contribution to Journal › Article (Published) -
Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand
In:
Nature Communications, vol. 10
DOI: https://doi.org/10.1038/s41467-019-12294-3
Research output: Contribution to Journal › Article (Published) -
Metabarcoding reveals a high diversity of woody host-associated Phytophthora spp. in soils at public gardens and amenity woodlands in Britain
(31 pages)
In:
PeerJ – the Journal of Life & Environmental Sciences
DOI: https://doi.org/10.7717/peerj.6931
Research output: Contribution to Journal › Article (Published) -
CD4 receptor diversity in chimpanzees protects against SIV infection
(10 pages)
In:
Proceedings of the National Academy of Sciences (PNAS)
DOI: https://doi.org/10.1073/pnas.1821197116
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites
(10 pages)
In:
Proceedings of the National Academy of Sciences (PNAS), vol. 115, pp. E8450-E8459
DOI: https://doi.org/10.1073/pnas.1810053115
Research output: Contribution to Journal › Article (Published) -
CHIIMP: An automated high-throughput microsatellite genotyping platform reveals greater allelic diversity in wild chimpanzees
(18 pages)
In:
Ecology and Evolution, vol. 8, pp. 7946-7963
DOI: https://doi.org/10.1002/ece3.4302
Research output: Contribution to Journal › Article (Published) -
Investigating zoonotic infection barriers to ape Plasmodium parasites using faecal DNA analysis
(12 pages)
In:
International Journal For Parasitology, vol. 48, pp. 531-542
DOI: https://doi.org/10.1016/j.ijpara.2017.12.002
Research output: Contribution to Journal › Article (Published) -
Reply to Forni et al., “multiple selected changes may modulate the molecular interaction between laverania RH5 and Primate Basigin”
(3 pages)
In:
mBio, vol. 9
DOI: https://doi.org/10.1128/mBio.00917-18
Research output: Contribution to Journal › Letter (Published) -
Adaptive Evolution of RH5 in Ape Plasmodium species of the Laverania Subgenus
(11 pages)
In:
mBio, vol. 9
DOI: https://doi.org/10.1128/mBio.02237-17
Research output: Contribution to Journal › Article (Published) -
Morphological and genetic analyses of the invasive forest pathogen Phytophthora austrocedri reveal two clonal lineages colonised Britain and Argentina from a common ancestral population
(9 pages)
In:
Phytopathology, vol. 107, pp. 1532-1540
DOI: https://doi.org/10.1094/PHYTO-03-17-0126-R
Research output: Contribution to Journal › Article (Published) -
Wild bonobos host geographically restricted malaria parasites including a putative new Laverania species
(14 pages)
In:
Nature Communications, vol. 8
DOI: https://doi.org/10.1038/s41467-017-01798-5
Research output: Contribution to Journal › Article (Published) -
Effective Treatment of SIVcpz-Induced Immunodeficiency in a Captive Western Chimpanzee
(9 pages)
In:
Retrovirology, vol. 14, pp. 35-43
DOI: https://doi.org/10.1186/s12977-017-0359-0
Research output: Contribution to Journal › Article (Published) -
Out of Africa: Origins and evolution of the human malaria parasites Plasmodium falciparum and Plasmodium vivax
(11 pages)
In:
International Journal For Parasitology, vol. 47, pp. 87-97
DOI: https://doi.org/10.1016/j.ijpara.2016.05.008
Research output: Contribution to Journal › Article (Published) -
Resistance to Type 1 Interferons is a Major Determinant of HIV-1 Transmission Fitness
(10 pages)
In:
Proceedings of the National Academy of Sciences (PNAS), vol. 114, pp. 590-599
DOI: https://doi.org/10.1073/pnas.1620144114
Research output: Contribution to Journal › Article (Published)