Nick Colegrave

Contact details
- Tel: +44 (0)131 650 7705
- Email: N.Colegrave@ed.ac.uk
Availability
Rm. 159, Ashworth Building
Background
1987-1990 Undergraduate, Biological sciences, Sussex University
1992-1995 PhD Sheffield University
1995-1996 NATO Fellow, McGill University
1997-1998 Postdoctoral researcher, St Andrews University
1999 Postdoctoral researcher, Glasgow University
2000 Zoology demonstrator, Edinburgh University
2000-2003 NERC research fellow, Edinburgh University
2003-2007 Lecturer in Biology
2008-Present Senior Lecturer in Biology
Undergraduate teaching
Program Organiser Zoology honours
Origin and Diversity of Life 1
Evolution in Action 2
Field Zoology 3
Animal Diversity and Evolution 3
Project Design and Analysis (hons)
Experimental Immunology (hons)
Research summary
https://sites.google.com/site/statisticscolegrave/
Core research
My research interests are in the interface between ecology and evolution. Ecological interactions occur over a timescale of days or months, and have been viewed as essentially too quick to have relevance to long term evolution. Similarly, evolution was viewed as something that occurred over the millennia, and so of little importance to the day to day interactions studied by ecologists. However, it is slowly being realised that such a view is wrong and that the interaction between these fields is far more dynamic: The population dynamics of ecology will have profound effects on the selective forces of evolutionary biology which in turn will alter the properties of the organisms and affect their population dynamics. If we are to fully understand organic diversity, we need to consider both ecological and evolutionary forces, and the way in which they interact. Whilst my research has encompassed a wide range of organisms and specific questions, this general theme has run throughout. I do not limit myself to a single technique or study system, but instead attempt to use the best system for any particular question, often requiring a mixture of experimental and theoretical techniques. I am also actively involved in bringing evolutionary approaches to other field of biology, in particular infectious disease biology, and am part of several collaborative projects in this area.
Teaching interests
During the 15 years that I have been teaching at the University of Edinburgh it has become apparent to me that the major educational challenge in training biologists remains finding ways to engage them with issues of experimental design and statistics. Much of my current teaching focuses on addressing these issues, designing both courses and teaching materials to improve the statistical literacy of biology students and animal researchers. In support of this I have produced an introductory textbook on experimental design for life sciences. For more information on this, please see my statistics webpage (link above)
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The effect of heterospecific and conspecific competition on inter-individual differences in tungara frog tadpole (Engystomops pustulosus) behavior: Effect of competition on variation in tadpole behavior
(12 pages)
In:
Behavioral Ecology, pp. 1-13
DOI: https://doi.org/10.1093/beheco/arac109
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Raising attainment for low-scoring students through quectures: An analysis of achievement and engagement with personalised learning in lectures
(13 pages)
In:
International journal of STEM education, vol. 9
DOI: https://doi.org/10.1186/s40594-022-00360-0
Research output: Contribution to Journal › Article (Published) -
The distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii inferred using frequency changes under experimental evolution
(20 pages)
In:
PLoS Genetics, vol. 18
DOI: https://doi.org/10.1371/journal.pgen.1009840
Research output: Contribution to Journal › Article (Published) -
De novo mutation rate variation and its determinants in Chlamydomonas
(15 pages)
In:
Molecular Biology and Evolution, vol. 38, pp. 3709–3723
DOI: https://doi.org/10.1093/molbev/msab140
Research output: Contribution to Journal › Article (Published) -
Sex increases the probability of evolutionary rescue in the presence of a competitor
In:
Journal of Evolutionary Biology, vol. 32
DOI: https://doi.org/10.1111/jeb.13525
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The effects of individual nonheritable variation on fitness estimation and coexistence
In:
Ecology and Evolution, vol. 9
DOI: https://doi.org/10.1002/ece3.5437
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Patterns of population structure and complex haplotype sharing among field isolates of the green alga Chlamydomonas reinhardtii
In:
Molecular Ecology, vol. 28, pp. 3977-3993
DOI: https://doi.org/10.1111/mec.15193
Research output: Contribution to Journal › Article (Published) -
Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii
In:
PLoS Biology, vol. 17
DOI: https://doi.org/10.1371/journal.pbio.3000192
Research output: Contribution to Journal › Article (Published) -
Hook innovation boosts foraging efficiency in tool-using crows
(7 pages)
In:
Nature Ecology & Evolution
DOI: https://doi.org/10.1038/s41559-017-0429-7
Research output: Contribution to Journal › Article (Published) -
Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii
(12 pages)
In:
Evolution: International Journal of Organic Evolution, vol. 71, pp. 2918-2929
DOI: https://doi.org/10.1111/evo.13360
Research output: Contribution to Journal › Article (Published) -
The effect of selection history on extinction risk during severe environmental change: Selection history and extinction risk
In:
Journal of Evolutionary Biology
DOI: https://doi.org/10.1111/jeb.13147
Research output: Contribution to Journal › Article (Published) -
Evolutionary consequences of multidriver environmental change in an aquatic primary producer
(6 pages)
In:
Proceedings of the National Academy of Sciences (PNAS), vol. 114, pp. 9930-9935
DOI: https://doi.org/10.1073/pnas.1703375114
Research output: Contribution to Journal › Article (Published) -
The effect of sex on the repeatability of evolution in different environments
(13 pages)
In:
Evolution: International Journal of Organic Evolution, vol. 71, pp. 1075-1087
DOI: https://doi.org/10.1111/evo.13198
Research output: Contribution to Journal › Article (Published) -
Statistical model specification and power: recommendations on the use of test-qualified pooling in analysis of experimental data
In:
Proceedings of the Royal Society B-Biological Sciences, vol. 284
DOI: https://doi.org/10.1098/rspb.2016.1850
Research output: Contribution to Journal › Article (Published) -
Caging and uncaging genetics
In:
PLoS Biology, vol. 14
DOI: https://doi.org/10.1371/journal.pbio.1002525
Research output: Contribution to Journal › Article (Published) -
Direct estimate of the spontaneous mutation rate uncovers the effects of drift and recombination in the chlamydomonas reinhardtii plastid genome
(9 pages)
In:
Molecular Biology and Evolution, vol. 33, pp. 800-808
DOI: https://doi.org/10.1093/molbev/msv272
Research output: Contribution to Journal › Article (Published) -
Cathelicidins have direct antiviral activity against respiratory syncytial virus in vitro and protective function in vivo in mice and humans.
(11 pages)
In:
The Journal of Immunology, vol. 196, pp. 2699-2710
DOI: https://doi.org/10.4049/jimmunol.1502478
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Fitness effects of new mutations in Chlamydomonas reinhardtii across two stress gradients
In:
Journal of Evolutionary Biology
DOI: https://doi.org/10.1111/jeb.12807
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Extensive de novo mutation rate variation between individuals and across the genome of Chlamydomonas reinhardtii
(12 pages)
In:
Genome Research, vol. 25, pp. 1739-1749
DOI: https://doi.org/10.1101/gr.191494.115
Research output: Contribution to Journal › Article (Published) -
Experimental adaptation to marine conditions by a freshwater alga
(14 pages)
In:
Evolution: International Journal of Organic Evolution, vol. 69, pp. 2662-2675
DOI: https://doi.org/10.1111/evo.12760
Research output: Contribution to Journal › Article (Published)