Neeraj Dhaun (Bean)
Senior Clinical Lecturer & Honorary Consultant Nephrologist
Address
- Street
-
The Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My group’s research focuses on the cardiovascular risk associated with the spectrum of chronic kidney disease from early in the disease trajectory through to end-stage renal failure requiring either dialysis or kidney transplantation. We perform pre-clinical and clinical pharmacology studies as well as investigating cardiovascular risk at a population level. Our goals are to identify cardiovascular risk early in patients with CKD and, through to investigate novel therapies that might reduce this risk and so improve longer-term patient outcomes.
Current projects
1. The role of innate immunity in hypertension & vascular dysfunction. Using macrophage depleting and modifying strategies we are investigating the role of this very plastic cell in the development and complications of hypertension. We use a number of mouse models of disease including high salt diet, endothelin-1 infusion and angiotensin II infusion.
2. The transition from acute kidney injury (AKI) through to chronic kidney disease. Here we use a mouse model of ischaemia-reperfusion injury to investigate new experimental medicine strategies to reduce the risk of developing CKD after AKI.
3. Chorioretinal thinning in chronic kidney disease. Using optical coherence tomography (OCT) we have recently shown that the retina and choroid are thinned in patients with CKD and this thinning relates to the degree of renal dysfunction as well as inflammation and endothelial dysfunction. We are now exploring the utility of these OCT measures as potential end points in experimental medicine studies.
4. The role of microRNAs in small vessel vasculitis. We are currently exploring the role of specific microRNAs as biomarkers of disease activity in ANCA vasculitis. Our clinical studies are supported by relevant pre-clinical models where we are investigating the roles of these microRNAs as mediators of renal and extra-renal disease.
5. Assessment & treatment of cardiovascular disease in patients with chronic kidney disease. Using large datasets we are investigating the role of high sensitivity troponin I as a measure of outcome in CKD patients presenting to the emergency department with chest pain. Using meta-analyses we are exploring the therapeutic disenfranchisement that CKD patients suffer in terms of pharmacological management of their cardiovascular disease.
6. Novel imaging techniques in large vessel vasculitis. We are currently investigating the role of hybrid PET/MR imaging for monitoring disease activity in those with large vessel vasculitis. In addition, we are utilising optical coherence tomography alongside established measures of cardiovascular risk to determine the impact of microvascular dysfunction in those with this condition.
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High-Sensitivity Cardiac Troponin and the Diagnosis of Myocardial Infarction in Patients with Renal Impairment
In:
Kidney International
Research output: Contribution to Journal › Article (Accepted/In press) -
Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast-Induced Nephropathy - A Failure of Academic Clinical Science
In:
Clinical pharmacology and therapeutics
Research output: Contribution to Journal › Article (Accepted/In press) -
The acute pressure natriuresis response is suppressed by selective ETA receptor blockade
In:
Clinical science
DOI: https://doi.org/10.1042/CS20210937
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Salt and disease
In:
Nature Reviews Nephrology
Research output: Contribution to Journal › Article (Accepted/In press) -
Comment on: A novel model to assess disease activity in Takayasu arteritis based on 18F-FDG-PET/CT: a Chinese cohort study
In:
Rheumatology
DOI: https://doi.org/10.1093/rheumatology/keab802
Research output: Contribution to Journal › Comment/debate (Published) -
The changing role of glucocorticoids in the treatment of ANCA-associated vasculitis
In:
Kidney International
Research output: Contribution to Journal › Article (Accepted/In press) -
Large Vessel Vasculitis
In:
Nature Reviews Disease Primers
Research output: Contribution to Journal › Article (Accepted/In press) -
Strawberry carina as a presentation of ANCA-associated vasculitis
In:
Rheumatology
DOI: https://doi.org/10.1093/rheumatology/keab783
Research output: Contribution to Journal › Letter (Published) -
Infective endocarditis hospitalizations & outcomes in patients with end-stage kidney disease: a nationwide data-linkage study
In:
Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease
DOI: https://doi.org/10.1161/JAHA.121.022002
Research output: Contribution to Journal › Article (Published) -
Utility of interval kidney biopsy in ANCA-associated vasculitis
In:
Rheumatology
DOI: https://doi.org/10.1093/rheumatology/keab695
Research output: Contribution to Journal › Article (Published) -
The therapeutic potential of apelin in kidney disease
In:
Nature Reviews Nephrology
DOI: https://doi.org/10.1038/s41581-021-00461-z
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Effects of Spironolactone and Chlorthalidone on Cardiovascular Structure and Function in Chronic Kidney Disease: A Randomized, Open-Label Trial
In:
Clinical Journal of the American Society of Nephrology
Research output: Contribution to Journal › Article (Accepted/In press) -
Metformin in obese pregnancy has no adverse effects on cardiovascular risk in early childhood
In:
Journal of Developmental Origins of Health and Disease
DOI: https://doi.org/10.1017/S2040174421000301
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Implementation of High-Sensitivity Cardiac Troponin in Patients with Renal Impairment
In:
JAMA Internal Medicine
DOI: https://doi.org/10.1001/jamainternmed.2021.1184
Research output: Contribution to Journal › Letter (E-pub ahead of print) -
STARMEN: progress in membranous nephropathy?
In:
Kidney International
DOI: https://doi.org/10.1016/j.kint.2021.01.025
Research output: Contribution to Journal › Article (E-pub ahead of print) -
ANCA-associated renal vasculitis is associated with rurality but not seasonality or deprivation in a complete national cohort study
In:
RMD Open, vol. 7, pp. e001555
DOI: https://doi.org/10.1136/rmdopen-2020-001555
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Resolving thrombo-inflammation
In:
Blood
DOI: https://doi.org/10.1182/blood.2020009963
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Hypertension: current trends & future perspectives
In:
British Journal of Clinical Pharmacology
DOI: https://doi.org/10.1111/bcp.14825
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Aortitis: recent advances, current concepts and future possibilities
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-318085
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease
In:
iScience
DOI: https://doi.org/10.1016/j.isci.2020.101937
Research output: Contribution to Journal › Article (E-pub ahead of print)