Neeraj Dhaun (Bean)
Senior Clinical Lecturer & Honorary Consultant Nephrologist
Address
- Street
-
The Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My group’s research focuses on the cardiovascular risk associated with the spectrum of chronic kidney disease from early in the disease trajectory through to end-stage renal failure requiring either dialysis or kidney transplantation. We perform pre-clinical and clinical pharmacology studies as well as investigating cardiovascular risk at a population level. Our goals are to identify cardiovascular risk early in patients with CKD and, through to investigate novel therapies that might reduce this risk and so improve longer-term patient outcomes.
Current projects
1. The role of innate immunity in hypertension & vascular dysfunction. Using macrophage depleting and modifying strategies we are investigating the role of this very plastic cell in the development and complications of hypertension. We use a number of mouse models of disease including high salt diet, endothelin-1 infusion and angiotensin II infusion.
2. The transition from acute kidney injury (AKI) through to chronic kidney disease. Here we use a mouse model of ischaemia-reperfusion injury to investigate new experimental medicine strategies to reduce the risk of developing CKD after AKI.
3. Chorioretinal thinning in chronic kidney disease. Using optical coherence tomography (OCT) we have recently shown that the retina and choroid are thinned in patients with CKD and this thinning relates to the degree of renal dysfunction as well as inflammation and endothelial dysfunction. We are now exploring the utility of these OCT measures as potential end points in experimental medicine studies.
4. The role of microRNAs in small vessel vasculitis. We are currently exploring the role of specific microRNAs as biomarkers of disease activity in ANCA vasculitis. Our clinical studies are supported by relevant pre-clinical models where we are investigating the roles of these microRNAs as mediators of renal and extra-renal disease.
5. Assessment & treatment of cardiovascular disease in patients with chronic kidney disease. Using large datasets we are investigating the role of high sensitivity troponin I as a measure of outcome in CKD patients presenting to the emergency department with chest pain. Using meta-analyses we are exploring the therapeutic disenfranchisement that CKD patients suffer in terms of pharmacological management of their cardiovascular disease.
6. Novel imaging techniques in large vessel vasculitis. We are currently investigating the role of hybrid PET/MR imaging for monitoring disease activity in those with large vessel vasculitis. In addition, we are utilising optical coherence tomography alongside established measures of cardiovascular risk to determine the impact of microvascular dysfunction in those with this condition.
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Corrigendum to "Novel retinal vascular phenotypes for the potential assessment of long-term risk in living kidney donors." Kidney Int. 2022;102:661-665
(2 pages)
In:
Kidney International, vol. 103, pp. 429-430
DOI: https://doi.org/10.1016/j.kint.2022.12.001
Research output: Contribution to Journal › Article (Published) -
Percutaneous Intervention in Takayasu Arteritis: Potential Advantages of Procedural Perseverance
In:
Journal of the American College of Cardiology
DOI: https://doi.org/10.1016/j.jacc.2022.11.009
Research output: Contribution to Journal › Editorial (Published) -
Endothelin blockade prevents the long-term cardiovascular & renal sequelae of acute kidney injury
In:
Science Translational Medicine
DOI: https://doi.org/10.1126/scitranslmed.abf5074
Research output: Contribution to Journal › Article (Published) -
High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvac160
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis
(12 pages)
In:
Kidney International, vol. 102, pp. 1115-1126
DOI: https://doi.org/10.1016/j.kint.2022.07.026
Research output: Contribution to Journal › Article (Published) -
Novel retinal vascular phenotypes for the potential assessment of long-term risk in living kidney donors
In:
Kidney International, vol. 102, pp. 661-665
DOI: https://doi.org/10.1016/j.kint.2022.06.019
Research output: Contribution to Journal › Letter (Published) -
Renin-Angiotensin and Endothelin Systems in Patients post Takotsubo Cardiomyopathy
In:
Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, vol. 11
DOI: https://doi.org/10.1161/JAHA.122.025989
Research output: Contribution to Journal › Article (Published) -
Remotely delivered cognitive behavioural and personalised exercise interventions for fatigue severity and impact in inflammatory rheumatic diseases (LIFT): a multicentre, randomised, controlled, open-label, parallel-group trial
In:
The Lancet Rheumatology
DOI: https://doi.org/10.1016/S2665-9913(22)00156-4
Research output: Contribution to Journal › Article (Published) -
Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function
In:
British Journal of Clinical Pharmacology
DOI: https://doi.org/10.1111/bcp.15446
Research output: Contribution to Journal › Article (Published) -
Cardiovascular outcomes in patients with chronic kidney disease and COVID-19: a multi-regional data-linkage study
In:
European Respiratory Journal
DOI: https://doi.org/10.1183/13993003.03168-2021
Research output: Contribution to Journal › Article (E-pub ahead of print) -
High-Sensitivity Cardiac Troponin and the Diagnosis of Myocardial Infarction in Patients with Renal Impairment
In:
Kidney International
DOI: https://doi.org/10.1016/j.kint.2022.02.019
Research output: Contribution to Journal › Article (Published) -
The changing role of glucocorticoids in the treatment of ANCA-associated vasculitis
In:
Kidney International, vol. 101, pp. 201-204
DOI: https://doi.org/10.1016/j.kint.2021.11.006
Research output: Contribution to Journal › Editorial (Published) -
Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast-Induced Nephropathy - A Failure of Academic Clinical Science
In:
Clinical Pharmacology & Therapeutics
DOI: https://doi.org/10.1002/cpt.2541
Research output: Contribution to Journal › Article (Published) -
The impact of excessive salt intake on human health
In:
Nature Reviews Nephrology, vol. 18, pp. 321-335
DOI: https://doi.org/10.1038/s41581-021-00533-0
Research output: Contribution to Journal › Article (Published) -
Large Vessel Vasculitis
In:
Nature Reviews Disease Primers, vol. 7
DOI: https://doi.org/10.1038/s41572-021-00327-5
Research output: Contribution to Journal › Article (Published) -
The acute pressure natriuresis response is suppressed by selective ETA receptor blockade
In:
Clinical science
DOI: https://doi.org/10.1042/CS20210937
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Comment on: A novel model to assess disease activity in Takayasu arteritis based on 18F-FDG-PET/CT: a Chinese cohort study
In:
Rheumatology
DOI: https://doi.org/10.1093/rheumatology/keab802
Research output: Contribution to Journal › Comment/debate (Published) -
Strawberry carina as a presentation of ANCA-associated vasculitis
In:
Rheumatology
DOI: https://doi.org/10.1093/rheumatology/keab783
Research output: Contribution to Journal › Letter (Published) -
Effects of Spironolactone and Chlorthalidone on Cardiovascular Structure and Function in Chronic Kidney Disease: A Randomized, Open-Label Trial
In:
Clinical Journal of the American Society of Nephrology
DOI: https://doi.org/10.2215/CJN.01930221
Research output: Contribution to Journal › Article (Published) -
Infective endocarditis hospitalizations & outcomes in patients with end-stage kidney disease: a nationwide data-linkage study
In:
Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease
DOI: https://doi.org/10.1161/JAHA.121.022002
Research output: Contribution to Journal › Article (Published)