Neeraj Dhaun (Bean)
Senior Clinical Lecturer & Honorary Consultant Nephrologist
Address
- Street
-
The Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My group’s research focuses on the cardiovascular risk associated with the spectrum of chronic kidney disease from early in the disease trajectory through to end-stage renal failure requiring either dialysis or kidney transplantation. We perform pre-clinical and clinical pharmacology studies as well as investigating cardiovascular risk at a population level. Our goals are to identify cardiovascular risk early in patients with CKD and, through to investigate novel therapies that might reduce this risk and so improve longer-term patient outcomes.
Current projects
1. The role of innate immunity in hypertension & vascular dysfunction. Using macrophage depleting and modifying strategies we are investigating the role of this very plastic cell in the development and complications of hypertension. We use a number of mouse models of disease including high salt diet, endothelin-1 infusion and angiotensin II infusion.
2. The transition from acute kidney injury (AKI) through to chronic kidney disease. Here we use a mouse model of ischaemia-reperfusion injury to investigate new experimental medicine strategies to reduce the risk of developing CKD after AKI.
3. Chorioretinal thinning in chronic kidney disease. Using optical coherence tomography (OCT) we have recently shown that the retina and choroid are thinned in patients with CKD and this thinning relates to the degree of renal dysfunction as well as inflammation and endothelial dysfunction. We are now exploring the utility of these OCT measures as potential end points in experimental medicine studies.
4. The role of microRNAs in small vessel vasculitis. We are currently exploring the role of specific microRNAs as biomarkers of disease activity in ANCA vasculitis. Our clinical studies are supported by relevant pre-clinical models where we are investigating the roles of these microRNAs as mediators of renal and extra-renal disease.
5. Assessment & treatment of cardiovascular disease in patients with chronic kidney disease. Using large datasets we are investigating the role of high sensitivity troponin I as a measure of outcome in CKD patients presenting to the emergency department with chest pain. Using meta-analyses we are exploring the therapeutic disenfranchisement that CKD patients suffer in terms of pharmacological management of their cardiovascular disease.
6. Novel imaging techniques in large vessel vasculitis. We are currently investigating the role of hybrid PET/MR imaging for monitoring disease activity in those with large vessel vasculitis. In addition, we are utilising optical coherence tomography alongside established measures of cardiovascular risk to determine the impact of microvascular dysfunction in those with this condition.
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Aortitis: recent advances, current concepts and future possibilities
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-318085
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease
In:
iScience
DOI: https://doi.org/10.1016/j.isci.2020.101937
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Glucocorticoid-free treatment of severe ANCA-associated vasculitis
In:
Nephrology dialysis transplantation
DOI: https://doi.org/10.1093/ndt/gfaa310
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Hypertension & vascular inflammation: another piece of the genetic puzzle
In:
Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.120.16420
Research output: Contribution to Journal › Editorial (E-pub ahead of print) -
Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells
In:
EBioMedicine, vol. 62
DOI: https://doi.org/10.1016/j.ebiom.2020.103092
Research output: Contribution to Journal › Article (Published) -
A framework for the discovery of retinal biomarkers in Optical Coherence Tomography Angiography (OCTA)
(10 pages)
DOI: https://doi.org/10.1007/978-3-030-63419-3_16
Research output: Contribution to Workshop › Conference contribution (Published) -
Activation of the sympathetic nervous system promotes blood pressure salt-sensitivity in C57BL6/J mice
In:
Hypertension
DOI: https://doi.org/10.1161/hypertensionaha.120.16186
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Extracellular RNA in kidney disease: moving slowly but surely from bench to bedside
In:
Clinical science, vol. 134
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The eye as a non-invasive window to the microcirculation in liver cirrhosis: a prospective pilot study
In:
Journal of Clinical Medicine
DOI: https://doi.org/10.3390/jcm9103332
Research output: Contribution to Journal › Article (Published) -
Multimorbidity in Anti-Neutrophil Cytoplasmic Antibody-associated vasculitis: results from a longitudinal, multi-centre data-linkage study
In:
Arthritis & Rheumatology
DOI: https://doi.org/10.1002/art.41557
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Serial troponin measurements to monitor risk & response to endothelin-A antagonism in chronic kidney disease Research Letter
In:
Nephrology dialysis transplantation
DOI: https://doi.org/10.1093/ndt/gfaa214
Research output: Contribution to Journal › Letter (E-pub ahead of print) -
Coronary Vasospasm in Eosinophilic Granulomatosis with Polyangiitis
In:
Rheumatology
DOI: https://doi.org/10.1093/rheumatology/keaa357
Research output: Contribution to Journal › Article (Published) -
Resistant Hypertension in a Dialysis Patient
In:
Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.120.15022
Research output: Contribution to Journal › Article (Published) -
Deletion of the myeloid endothelin-B receptor confers long-term protection from angiotensin II-mediated renal, retinal & vascular injury
In:
Kidney International
DOI: https://doi.org/10.1016/j.kint.2020.05.042
Research output: Contribution to Journal › Article (Published) -
Easily missed: ANCA-associated vasculitis
In:
British Medical Journal (BMJ)
DOI: https://doi.org/10.1136/bmj.m1070
Research output: Contribution to Journal › Article (Published) -
Endothelin-1 mediates the systemic and renal hemodynamic effects of GPR81 activation
In:
Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.119.14308
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Characterising infection in ANCA-associated vasculitis: results from a longitudinal, matched-cohort data linkage study
In:
Rheumatology
DOI: https://doi.org/10.1093/rheumatology/keaa070
Research output: Contribution to Journal › Article (Published) -
The eye, the kidney & cardiovascular disease: old concepts, better tools & new horizons
In:
Kidney International
DOI: https://doi.org/10.1016/j.kint.2020.01.039
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Effect of Exercise Intensity and Duration on Cardiac Troponin Release
(3 pages)
In:
Circulation, vol. 141, pp. 83-85
DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.041874
Research output: Contribution to Journal › Article (Published) -
Effect of Exercise Intensity and Duration on Cardiac Troponin Release
In:
Circulation
DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.041874
Research output: Contribution to Journal › Letter (Published)