Mihaela Crisan
Chancellor's Fellow
Address
- Street
-
Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
We address two major research questions in my lab: 1) we study the role of pericytes and its interactions with endothelial cells in all organs where hematopoietic stem cells travel during mouse ontogeny and 2) the role of pericytes:endothelial cell interaction in heart and kidney homeostasis and function. Our in vivo studies have implications in both leukemia and cardiovascular disease.
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Protocol to analyze and validate transcriptomic changes in PDGFRβ-KO mesenchymal stem cell osteogenic potential in the mouse embryo
In:
STAR Protocols, vol. 4
DOI: https://doi.org/10.1016/j.xpro.2022.102016
Research output: Contribution to Journal › Article (Published) -
PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny
In:
Cell Reports, vol. 40
DOI: https://doi.org/10.1016/j.celrep.2022.111114
Research output: Contribution to Journal › Article (Published) -
Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition
In:
Nature Metabolism, vol. 4, pp. 123-140
DOI: https://doi.org/10.1038/s42255-021-00514-4
Research output: Contribution to Journal › Article (Published) -
Resident cells of the myocardium:more than spectators in cardiac injury, repair and regeneration
(6 pages)
In:
Current opinion in physiology, vol. 1, pp. 46-51
DOI: https://doi.org/10.1016/j.cophys.2017.08.001
Research output: Contribution to Journal › Review article (Published) -
Isolation and characterization of canine perivascular stem/stromal cells for bone tissue engineering
In:
PLoS ONE, vol. 12, pp. e0177308
DOI: https://doi.org/10.1371/journal.pone.0177308
Research output: Contribution to Journal › Article (Published) -
The many faces of hematopoietic stem cell heterogeneity
In:
Development
DOI: https://doi.org/10.1242/dev.114231
Research output: Contribution to Journal › Article (Published) -
Pericytes, integral components of adult hematopoietic stem cell niches
In:
Pharmacology and Therapeutics
DOI: https://doi.org/10.1016/j.pharmthera.2016.11.006
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Resident PW1+ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension
(12 pages)
In:
Circulation Research, vol. 118, pp. 822-833
DOI: https://doi.org/10.1161/CIRCRESAHA.115.307035
Research output: Contribution to Journal › Article (Published) -
BMP and Hedgehog regulate distinct AGM hematopoietic stem cells ex vivo
In:
Stem Cell Reports
DOI: https://doi.org/10.1016/j.stemcr.2016.01.016
Research output: Contribution to Journal › Article (Published) -
BMP signalling differentially regulates distinct hematopoietic stem cell types
(8 pages)
In:
Nature Communications, vol. 6
DOI: https://doi.org/10.1038/ncomms9040
Research output: Contribution to Journal › Article (Published) -
Isolation of blood-vessel-derived multipotent precursors from human skeletal muscle
In:
Journal of Visualized Experiments (JoVE), pp. e51195
DOI: https://doi.org/10.3791/51195
Research output: Contribution to Journal › Article (Published) -
HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo
(12 pages)
In:
Stem Cell Research, vol. 12, pp. 24-35
DOI: https://doi.org/10.1016/j.scr.2013.09.006
Research output: Contribution to Journal › Article (Published) -
Identification of perivascular mesenchymal stromal/stem cells by flow cytometry
(7 pages)
In:
Cytometry Part A, vol. 83, pp. 714-20
DOI: https://doi.org/10.1002/cyto.a.22313
Research output: Contribution to Journal › Article (Published) -
Human pericytes for ischemic heart repair
(12 pages)
In:
STEM CELLS, vol. 31, pp. 305-316
DOI: https://doi.org/10.1002/stem.1285
Research output: Contribution to Journal › Article (Published) -
The biochemistry of hematopoietic stem cell development
(9 pages)
In:
BBA - Bioenergetics, vol. 1830, pp. 2395-403
DOI: https://doi.org/10.1016/j.bbagen.2012.10.004
Research output: Contribution to Journal › Literature review (Published) -
Transition of mesenchymal stem/stromal cells to endothelial cells
In:
Current stem cell research & therapy, vol. 4, pp. 95
DOI: https://doi.org/10.1186/scrt306
Research output: Contribution to Journal › Comment/debate (Published) -
Perivascular cells for regenerative medicine
(10 pages)
In:
Journal of Cellular and Molecular Medicine, vol. 16, pp. 2851-60
DOI: https://doi.org/10.1111/j.1582-4934.2012.01617.x
Research output: Contribution to Journal › Literature review (Published) -
Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle
(4 pages)
In:
International Journal of Obesity, vol. 36, pp. 155-158
DOI: https://doi.org/10.1038/ijo.2011.85
Research output: Contribution to Journal › Article (Published) -
The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization
(11 pages)
In:
Blood, vol. 117, pp. 5620-30
DOI: https://doi.org/10.1182/blood-2010-08-300236
Research output: Contribution to Journal › Article (Published) -
Differentiation and migration properties of human foetal umbilical cord perivascular cells: potential for lung repair
(13 pages)
In:
Journal of Cellular and Molecular Medicine, vol. 15, pp. 796-808
DOI: https://doi.org/10.1111/j.1582-4934.2010.01047.x
Research output: Contribution to Journal › Article (Published)