Michael Eddleston
Personal Chair of Clinical Toxicology

- Centre for Cardiovascular Science
- Centre for Pesticide Suicide Prevention
Contact details
- Tel: 0131 242 1383
- Email: m.eddleston@ed.ac.uk
Address
- Street
-
The Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My work’s major aim is to reduce deaths from pesticide and plant self-poisoning in rural Asia, a cause of over 200,000 premature deaths each year and a key global means of suicide. To do this, I perform clinical trials in South Asian district hospitals to better understand the pharmacology and effectiveness of antidotes and community-based controlled trials to identify effective public health interventions. This work is complemented by large animal translational studies of antidotes in Edinburgh, work with sociologists and anthropologists to better understand the meaning of self-harm, and work with the World Health Organisation and Food & Agriculture Organisation to aid implementation. I also perform clinical and pre-clinical research in Edinburgh to improve treatment of other forms of poisoning (such as from cyanide, alcohol, and contrast media) by developing and/or testing novel antidotes
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Suicides by pesticide ingestion in Pakistan and the impact of pesticide regulation
In:
BMC Public Health, vol. 23
DOI: https://doi.org/10.1186/s12889-023-15505-1
Research output: Contribution to Journal › Article (Published) -
Conceptualising the commercial determinants of suicide: broadening the lens on suicide and self-harm prevention
(8 pages)
In:
The Lancet Psychiatry, vol. 10, pp. 363-370
DOI: https://doi.org/10.1016/S2215-0366(23)00043-3
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Co-Benefits of Largescale Organic farming On huMan health (BLOOM):: Protocol for a cluster-randomised controlled evaluation of the Andhra Pradesh Community-managed Natural Farming programme in India
(26 pages)
In:
PLoS ONE, vol. 18, pp. 1-26
DOI: https://doi.org/10.1371/journal.pone.0281677
Research output: Contribution to Journal › Article (Published) -
Dose ingested, vomiting, and outcome in patients ingesting a standard paraquat 20SL formulation
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2022.2142601
Research output: Contribution to Journal › Article (Published) -
Involvement of alcohol in injury cases in rural Sri Lanka: Prevalence and associated factors among in-patients in three primary care hospitals
(10 pages)
In:
BMC Public Health, vol. 22, pp. 1-10
DOI: https://doi.org/10.1186/s12889-022-12958-8
Research output: Contribution to Journal › Article (Published) -
Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle
In:
British Journal of Pharmacology
DOI: https://doi.org/10.1111/bph.15940
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Current pesticide suicide surveillance methods used across the African continent – A scoping review protocol
In:
BMJ Open
DOI: https://doi.org/10.1136/bmjopen-2021-055923
Research output: Contribution to Journal › Article (Published) -
Evidence for the efficacy of the emetic PP796 in paraquat SL20 formulations – a narrative review of published and unpublished evidence
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2022.2105709
Research output: Contribution to Journal › Article (Published) -
‘Calcium bombs' as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions
(18 pages)
In:
Frontiers in Molecular Neuroscience, vol. 15
DOI: https://doi.org/10.3389/fnmol.2022.937974
Research output: Contribution to Journal › Article (Published) -
Bites by exotic snakes reported to the UK National Poisons Information Service 2009-2020
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2022.2077748
Research output: Contribution to Journal › Article (Published) -
Trends in hospital presentations following analytically confirmed synthetic cannabinoid receptor agonist exposure before and after implementation of the 2016 UK Psychoactive Substances Act
In:
Addiction
DOI: https://doi.org/10.1111/add.15967
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Peppermint protocol: first results for gas chromatography-ion mobility spectrometry
In:
Journal of Breath Research
DOI: https://doi.org/10.1088/1752-7163/ac6ca0
Research output: Contribution to Journal › Article (Published) -
Toxicity of phosphate enemas - an updated review
In:
Clinical Toxicology, vol. 60, pp. 672-680
DOI: https://doi.org/10.1080/15563650.2022.2054424
Research output: Contribution to Journal › Review article (Published) -
Pesticide use, agricultural outputs, and pesticide poisoning deaths in Japan
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2022.2064868
Research output: Contribution to Journal › Article (Published) -
Fast and automated biomarker detection in breath samples with machine learning
In:
PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0265399
Research output: Contribution to Journal › Article (Published) -
Impact of large-scale, government-legislated and funded organic farming training on pesticide use: A cross-sectional study from Andhra Pradesh, India
In:
The Lancet Planetary Health, vol. 6, pp. e310-e319
DOI: https://doi.org/10.1016/S2542-5196(22)00062-6
Research output: Contribution to Journal › Article (Published) -
Gatekeeper training for vendors to reduce pesticide self-poisoning in rural South Asia - A study protocol for a stepped-wedge cluster randomized controlled trial
In:
BMJ Open
DOI: https://doi.org/10.1136/bmjopen-2021-054061
Research output: Contribution to Journal › Article (Published) -
Lung injury caused by aspiration of organophosphorus insecticide and gastric contents in pigs
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2022.2028803
Research output: Contribution to Journal › Article (Published) -
Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast-Induced Nephropathy - A Failure of Academic Clinical Science
In:
Clinical Pharmacology & Therapeutics
DOI: https://doi.org/10.1002/cpt.2541
Research output: Contribution to Journal › Article (Published) -
Impact of regional bans of highly hazardous pesticides on agricultural yields: the case of Kerala
In:
Agriculture and Food Security, vol. 11
DOI: https://doi.org/10.1186/s40066-021-00348-z
Research output: Contribution to Journal › Article (Published)