Michael Eddleston
Personal Chair of Clinical Toxicology
Address
- Street
-
The Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My work’s major aim is to reduce deaths from pesticide and plant self-poisoning in rural Asia, a cause of over 200,000 premature deaths each year and a key global means of suicide. To do this, I perform clinical trials in South Asian district hospitals to better understand the pharmacology and effectiveness of antidotes and community-based controlled trials to identify effective public health interventions. This work is complemented by large animal translational studies of antidotes in Edinburgh, work with sociologists and anthropologists to better understand the meaning of self-harm, and work with the World Health Organisation and Food & Agriculture Organisation to aid implementation. I also perform clinical and pre-clinical research in Edinburgh to improve treatment of other forms of poisoning (such as from cyanide, alcohol, and contrast media) by developing and/or testing novel antidotes
-
Breath markers for therapuetic radiation
In:
Journal of Breath Research
DOI: https://doi.org/10.1088/1752-7163/aba816
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Factors associated with purchasing pesticide from shops for intentional self-poisoning in Sri Lanka
In:
Tropical Medicine and International Health
DOI: https://doi.org/10.1111/tmi.13469
Research output: Contribution to Journal › Article (Published) -
Using ex-ante economic evaluation to inform research priorities in pesticide self-poisoning prevention: The case of a shop-based gatekeeper training programme in rural Sri Lanka
In:
Tropical Medicine and International Health
DOI: https://doi.org/10.1111/tmi.13470
Research output: Contribution to Journal › Article (Published) -
Comment on fomepizole as an adjunctive treatment in severe acetaminophen ingestions
In:
Clinical Toxicology, pp. 1-1
DOI: https://doi.org/10.1080/15563650.2020.1788056
Research output: Contribution to Journal › Article (Published) -
Use of the online poisons information database TOXBASE and admissions rates for poisoned patients from emergency departments in England and Wales during 2008 to 2015
In:
Journal of American College of Emergency Physicians Open
DOI: https://doi.org/10.1002/emp2.12116
Research output: Contribution to Journal › Article (Published) -
Emerging pesticides responsible for suicide in rural Sri Lanka following the 2008-2014 pesticide bans
In:
BMC Public Health
DOI: https://doi.org/10.1186/s12889-020-08871-7
Research output: Contribution to Journal › Article (Published) -
Suicide by pesticide poisoning in India: a review of pesticide regulations and their impact on suicide trends
In:
BMC Public Health, vol. 20
DOI: https://doi.org/10.1186/s12889-020-8339-z
Research output: Contribution to Journal › Article (Published) -
Preventing suicide through pesticide regulation
In:
Lancet Psychiatry
DOI: https://doi.org/10.1016/S2215-0366(19)30478-X
Research output: Contribution to Journal › Letter (Published) -
Does oxidative stress contribute to toxicity in acute organophosphorus poisoning? – a systematic review of the evidence
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2019.1693589
Research output: Contribution to Journal › Literature review (Published) -
VOCCluster: Untargeted Metabolomics Feature Clustering Approach for Clinical Breath Gas Chromatography - Mass Spectrometry Data
In:
Analytical Chemistry
DOI: https://doi.org/10.1021/acs.analchem.9b03084
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Estimating the government health care costs of treating pesticide poisoned and pesticide self-poisoned patients in Sri Lanka
In:
Global Health Action
DOI: https://doi.org/10.1080/16549716.2019.1692616
Research output: Contribution to Journal › Article (Published) -
Response to the letter from Wong et al.
In:
EClinicalMedicine
DOI: https://doi.org/10.1016/j.eclinm.2019.09.002
Research output: Contribution to Journal › Letter (Published) -
How many premature deaths from pesticide suicide have occurred since the agricultural Green Revolution?
In:
Clinical Toxicology, pp. 1-6
DOI: https://doi.org/10.1080/15563650.2019.1662433
Research output: Contribution to Journal › Article (Published) -
Efficacy of an Organophosphorus Hydrolase Enzyme (OpdA) in Human Serum and Minipig Models of Organophosphorus Insecticide Poisoning
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2019.1655149
Research output: Contribution to Journal › Article (Published) -
Modest and variable efficacy of pre-exposure hydroxocobalamin and dicobalt edetate in a porcine model of acute cyanide salt poisoning
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2019.1628969
Research output: Contribution to Journal › Article (E-pub ahead of print) -
A pilot clinical study of the neuromuscular blocker rocuronium to reduce the duration of ventilation after organophosphorus insecticide poisoning
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2019.1643467
Research output: Contribution to Journal › Article (Published) -
Consensus statements on the approach to patients in a methanol poisoning outbreak
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2019.1636992
Research output: Contribution to Journal › Article (Published) -
Risk of suicide and repeat self-harm after hospital attendance for non-fatal self-harm in Sri Lanka: a cohort study
In:
Lancet Psychiatry
DOI: https://doi.org/10.1016/S2215-0366(19)30214-7
Research output: Contribution to Journal › Article (Published) -
Acute toxicity following analytically confirmed use of the novel psychoactive substance (NPS) methiopropamine. A report from the Identification of Novel psychoActive substances (IONA) study
(5 pages)
In:
Clinical Toxicology, vol. 57, pp. 663-667
DOI: https://doi.org/10.1080/15563650.2018.1538519
Research output: Contribution to Journal › Article (Published) -
Safety and efficacy of the SNAP 12 hour acetylcysteine regimen for the treatment of paracetamol overdose
In:
EClinicalMedicine
DOI: https://doi.org/10.1016/j.eclinm.2019.04.005
Research output: Contribution to Journal › Article (Published)