Michael Eddleston
Personal Chair of Clinical Toxicology
- Centre for Cardiovascular Science
- Centre for Pesticide Suicide Prevention
Contact details
- Tel: 0131 242 1383
- Email: m.eddleston@ed.ac.uk
Address
- Street
-
The Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My work’s major aim is to reduce deaths from pesticide and plant self-poisoning in rural Asia, a cause of over 200,000 premature deaths each year and a key global means of suicide. To do this, I perform clinical trials in South Asian district hospitals to better understand the pharmacology and effectiveness of antidotes and community-based controlled trials to identify effective public health interventions. This work is complemented by large animal translational studies of antidotes in Edinburgh, work with sociologists and anthropologists to better understand the meaning of self-harm, and work with the World Health Organisation and Food & Agriculture Organisation to aid implementation. I also perform clinical and pre-clinical research in Edinburgh to improve treatment of other forms of poisoning (such as from cyanide, alcohol, and contrast media) by developing and/or testing novel antidotes
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Characteristics and psychopathology of 1,086 patients who self-poisoned using pesticides in Taiwan (2012–2019): A comparison across pesticide groups
In:
Journal of affective disorders, vol. 300, pp. 17-26
DOI: https://doi.org/10.1016/j.jad.2021.12.058
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Impact of regional bans of highly hazardous pesticides on agricultural yields: the case of Kerala
In:
Agriculture & Food Security
Research output: Contribution to Journal › Article (Accepted/In press) -
Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma
In:
ACS Omega
DOI: https://doi.org/10.1021/acsomega.1c03827
Research output: Contribution to Journal › Article (Published) -
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients
In:
Clinical Toxicology
Research output: Contribution to Journal › Letter (Accepted/In press) -
Antagonistic postsynaptic and presynaptic actions of cyclohexanol on neuromuscular synaptic transmission and function
In:
Journal of Physiology
DOI: https://doi.org/10.1113/JP281921
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The 20-minute whole blood clotting test (20WBCT) for snakebite coagulopathy—A systematic review and meta-analysis of diagnostic test accuracy
In:
PLoS Neglected Tropical Diseases, vol. 15, pp. e0009657
DOI: https://doi.org/10.1371/journal.pntd.0009657
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Importance of pesticides for lethal poisoning in India during 1999 to 2018: a systematic review
In:
BMC Public Health
DOI: https://doi.org/10.1186/s12889-021-11156-2
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The early impact of paraquat ban on suicide in Taiwan
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2021.1937642
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Intentional pesticide poisoning and pesticide suicides in Nepal
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2021.1935993
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Suicide by pesticide ingestion in Nepal and the impact of pesticide regulation
In:
BMC Public Health
DOI: https://doi.org/10.1186/s12889-021-11155-3
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Impaired Neuromuscular Function by Conjoint Actions of Organophosphorus Insecticide Metabolites Omethoate and Cyclohexanol with Implications for Treatment of Respiratory Failure.
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2021.1916519
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Acute phenthoate self-poisoning: a prospective case series
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2021.1917596
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Case fatality of agricultural pesticides after self-poisoning in Sri Lanka: a prospective cohort study.
In:
The Lancet Global Health
DOI: https://doi.org/10.1016/S2214-109X(21)00086-3
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The cost-effectiveness of banning highly hazardous pesticides to prevent suicides due to pesticide self-ingestion across 14 countries: an economic modelling study
(10 pages)
In:
The Lancet Global Health, vol. 9, pp. E291-E300
DOI: https://doi.org/10.1016/S2214-109X(20)30493-9
Research output: Contribution to Journal › Article (Published) -
Moderate-to-severe Vipera berus envenoming requiring ViperaTAb antivenom therapy in the United Kingdom
In:
Clinical Toxicology
DOI: https://doi.org/10.1080/15563650.2021.1891245
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Prevention of pesticide suicides and the right to life - the intersection of human rights and public health priorities
In:
The Journal of Human Rights
DOI: https://doi.org/10.1080/14754835.2020.1850241
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Organophosphorus poisoning: the wet opioid toxidrome
In:
The Lancet
DOI: https://doi.org/10.1016/S0140-6736(20)32749-5
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Diagnosis of COVID-19 by analysis of breath with gas chromatography-ion mobility spectrometry - a feasibility study
In:
EClinicalMedicine, pp. 100609
DOI: https://doi.org/10.1016/j.eclinm.2020.100609
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Development of a histopathology scoring system for the pulmonary complications of organophosphorus insecticide poisoning in a pig model
In:
PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0240563
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Breath markers for therapuetic radiation
In:
Journal of Breath Research
DOI: https://doi.org/10.1088/1752-7163/aba816
Research output: Contribution to Journal › Article (E-pub ahead of print)