Mark Miller (BSc, PhD)
Senior Research Fellow
Address
- Street
-
Centre for Cardiovascular Science,
The Queen's Medical Research Institute,
Edinburgh BioQuarter,
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My research investigates the cardiovascular effects of air pollution, which are believed to be responsible for killing millions of people worldwide every year. I specialise in the biological mechanisms by which inhaled nanoparticles lead to detrimental effects on multiple aspects of the cardiovascular system. This work also encompasses engineered nanoparticles, the manufacture of which is increasing on an exponential scale for a diverse range of applications. These nanoparticles share many of the physicochemical properties with environmental particles, yet their potential to cause cardiovascular harm has received very little attention. I also have an interest in atherosclerosis, the vascular endothelium, nitric oxide and oxidative stress. Our group specialises in in vitro and in vivo models of vascular function, with immediate translational links to clinical research and public health.
Research activities
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Joint effect of multiple air pollutants on cardiometabolic health in normal-weight and obese adults: A novel insight into the role of circulating free fatty acids
In:
Science of the Total Environment
DOI: https://doi.org/10.1016/j.scitotenv.2022.159014
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Cardiopulmonary benefits of respirator intervention against near road ambient particulate matters in healthy young adults: A randomized, blinded, crossover, multi-city study
In:
Chemosphere, pp. 136437
DOI: https://doi.org/10.1016/j.chemosphere.2022.136437
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Exposure to elevated nitrogen dioxide concentrations and cardiac remodelling in patients with dilated cardiomyopathy
(11 pages)
In:
Journal of cardiac failure, vol. 28, pp. 924-934
DOI: https://doi.org/10.1016/j.cardfail.2021.11.023
Research output: Contribution to Journal › Article (Published) -
A Review of Road Traffic-Derived Non-Exhaust Particles: Emissions, Physicochemical Characteristics, Health Risks, and Mitigation Measures
In:
Environmental Science and Technology, vol. 56, pp. 6813-6835
DOI: https://doi.org/10.1021/acs.est.2c01072
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Nitrate and nitrite contamination in drinking water and cancer risk: A systematic review with meta-analysis
In:
Environmental Research, vol. 210, pp. 112988
DOI: https://doi.org/10.1016/j.envres.2022.112988
Research output: Contribution to Journal › Review article (Published) -
AIR POLLUTION AND CARDIOVASCULAR DISEASE The Paul Wood Lecture, British Cardiovascular Society 2021
In:
Heart, vol. 108, pp. 1267-1273
DOI: https://doi.org/10.1136/heartjnl-2021-319844
Research output: Contribution to Journal › Review article (Published) -
The cardiovascular effects of air pollution: Prevention and reversal by pharmacological agents
In:
Pharmacology and Therapeutics, pp. 107996
DOI: https://doi.org/10.1016/j.pharmthera.2021.107996
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Acute Cardiovascular Effects of Controlled Exposure to Dilute Petrodiesel and Biodiesel Exhaust in Healthy Volunteers: A Crossover Study
In:
Particle and Fibre Toxicology
DOI: https://doi.org/10.1186/s12989-021-00412-3
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Taking a stand against air pollution – The impact on cardiovascular disease: A joint opinion from the World Heart Federation, American College of Cardiology, American Heart Association, and the European Society of Cardiology
(4 pages)
In:
European Heart Journal, vol. 42, pp. 1460–1463
DOI: https://doi.org/10.1093/eurheartj/ehaa1025
Research output: Contribution to Journal › Article (Published) -
Reduction of environmental pollutants for prevention of cardiovascular disease: it’s time to act
In:
European Heart Journal
DOI: https://doi.org/10.1093/eurheartj/ehaa745
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Identification of potential markers for internal exposure to ambient ozone in oral cavity of healthy adults
In:
Environmental Research
DOI: https://doi.org/10.1016/j.envres.2020.109907
Research output: Contribution to Journal › Article (Published) -
Nanotoxicology: the need for a human touch?
In:
Small
DOI: https://doi.org/10.1002/smll.202001516
Research output: Contribution to Journal › Article (Published) -
The relationship between personal exposure and ambient PM2.5 and black carbon in Beijing
(14 pages)
In:
Science of the Total Environment, vol. 737
DOI: https://doi.org/10.1016/j.scitotenv.2020.139801
Research output: Contribution to Journal › Article (Published) -
Short-term exposure to carbon monoxide and myocardial infarction: A systematic review and meta-analysis
In:
Environment International
DOI: https://doi.org/10.1016/j.envint.2020.105901
Research output: Contribution to Journal › Article (Published) -
We all breathe the same air …. and we are all mortal
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvaa126
Research output: Contribution to Journal › Article (Published) -
Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer’s and vascular disease
In:
Neurochemistry International, vol. 138, pp. 104755
DOI: https://doi.org/10.1016/j.neuint.2020.104755
Research output: Contribution to Journal › Article (Published) -
New Opportunities to Mitigate the Burden of Disease Caused by Traffic Related Air Pollution: Antioxidant-Rich Diets and Supplements
In:
International Journal of Environmental Research and Public Health, vol. 17, pp. 630
DOI: https://doi.org/10.3390/ijerph17020630
Research output: Contribution to Journal › Literature review (Published) -
Polyaromatic hydrocarbons in pollution: a heart‐breaking matter
In:
The Journal of Physiology, vol. 598, pp. 227-247
DOI: https://doi.org/10.1113/tjp.v598.2
Research output: Contribution to Journal › Literature review (Published) -
Oxidative stress and the cardiovascular effects of air pollution
In:
Free Radical Biology and Medicine
DOI: https://doi.org/10.1016/j.freeradbiomed.2020.01.004
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Role of chemical composition and redox modification of poorly soluble nanomaterials on their ability to enhance allergic airway sensitisation in mice
In:
Particle and Fibre Toxicology, vol. 16
DOI: https://doi.org/10.1186/s12989-019-0320-6
Research output: Contribution to Journal › Article (Published)