Laura Denby
ESAT Fellow
Address
- Street
-
Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My primary area of research is investigating the role of non-coding RNA regulation of injury and repair processes within the kidney and cardiovascular system.Currently my group are interested in novel non-coding RNA, their target genes and pathways they target which are associated with renal injury, particular fibrosis and those involved in repair processes. In particular we are interested in dysregulation of non-coding RNA in the cardiovascular system in response to renal dysfunction.For the over 5 years I have been working in the field of small non-coding RNA, miRNAs, involved in renal dysfunction and exploiting this for clinical translation. We have established that dysregulation of several miRNAs, including miR-214, miR-21 and miR-29 family are implicitly involved in renal dysfunction and in particular renal fibrosis. Blockade of miRNA-214 and -21 using genetic or pharmacological agents has the potential to block renal fibrosis and we are pursuing this for clinical translation.Additionally my group has identified a miRNA signature which could potentially be used as a non-invasive biomarker of disease severity in IgA nephropathy (indicated by eGFR and renal biopsy assessment using the Oxford classification) or possibly in the wider CKD population. The signature could also be used to determine patients at high risk of progressive disease. Furthermore, this miRNA signature may represent a novel treatment responsive modifiable biomarker which would permit accelerated testing of new therapeutic interventions.
-
Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis
In:
JCI Insight, vol. 7
DOI: https://doi.org/10.1172/jci.insight.154124
Research output: Contribution to Journal › Article (Published) -
Sonoporation of human renal proximal tubular epithelial cells in vitro to enhance the liberation of intracellular miRNA biomarkers.
In:
Ultrasound in Medicine and Biology (UMB)
DOI: https://doi.org/10.1016/j.ultrasmedbio.2022.01.019
Research output: Contribution to Journal › Article (E-pub ahead of print) -
MicroRNAs and Their Delivery in Diabetic Fibrosis
In:
Advanced Drug Delivery Reviews, pp. 114045
DOI: https://doi.org/10.1016/j.addr.2021.114045
Research output: Contribution to Journal › Review article (Published) -
Myeloid heterogeneity in kidney disease as revealed through single cell RNA sequencing
In:
Kidney360, pp. 10.34067/KID.0003682021
DOI: https://doi.org/10.34067/KID.0003682021
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels
In:
Nature Communications
DOI: https://doi.org/10.1038/s41467-021-24684-7
Research output: Contribution to Journal › Article (E-pub ahead of print) -
CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.120.318688
Research output: Contribution to Journal › Article (Published) -
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.120.318124
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Identifying cell enriched miRNAs in kidney injury and repair
In:
JCI Insight, vol. 5
DOI: https://doi.org/10.1172/jci.insight.140399
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease
In:
Journal of the American Society of Nephrology, vol. 31, pp. 2833–2854
DOI: https://doi.org/10.1681/ASN.2020060806
Research output: Contribution to Journal › Article (Published) -
Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells
In:
EBioMedicine, vol. 62
DOI: https://doi.org/10.1016/j.ebiom.2020.103092
Research output: Contribution to Journal › Article (Published) -
Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants
In:
Immunity, vol. 52, pp. 700-715.e6
DOI: https://doi.org/10.1016/j.immuni.2020.03.011
Research output: Contribution to Journal › Article (Published) -
T-Cell–Derived miRNA-214 Mediates Perivascular Fibrosis in Hypertension
In:
Circulation Research, vol. 126, pp. 988–1003
DOI: https://doi.org/10.1161/CIRCRESAHA.119.315428
Research output: Contribution to Journal › Article (Published) -
Endothelin-1 mediates the systemic and renal hemodynamic effects of GPR81 activation
In:
Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.119.14308
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction
In:
Frontiers in physiology, vol. 10
DOI: https://doi.org/10.3389/fphys.2019.01365
Research output: Contribution to Journal › Article (Published) -
Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling
In:
Cell communication and signaling, vol. 17
DOI: https://doi.org/10.1186/s12964-019-0449-9
Research output: Contribution to Journal › Article (Published) -
MicroRNAs as Non-Invasive Biomarkers of Renal Disease
In:
Nephrology dialysis transplantation
DOI: https://doi.org/10.1093/ndt/gfz183
Research output: Contribution to Journal › Review article (Published) -
The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease
In:
Vascular pharmacology
DOI: https://doi.org/10.1016/j.vph.2018.11.006
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Urinary angiotensinogen as a biomarker for acute to chronic kidney injury transition – prognostic and mechanistic implications
In:
Clinical science, vol. 132, pp. 2383-2385
DOI: https://doi.org/10.1042/CS20180795
Research output: Contribution to Journal › Article (Published) -
Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum
In:
Journal of Virology, vol. 91
DOI: https://doi.org/10.1128/JVI.02487-16
Research output: Contribution to Journal › Article (Published) -
Relationship between circulating microRNA-30c with total- and LDL-cholesterol, their circulatory transportation and effect of statins
In:
Clinica Chimica Acta, vol. 466, pp. 13-19
DOI: https://doi.org/10.1016/j.cca.2016.12.031
Research output: Contribution to Journal › Article (Published)