Laura Denby

ESAT Fellow

  • Centre for Cardiovascular Science

Contact details

Address

Street

Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter

City
Edinburgh
Post code
EH16 4TJ

Research summary

My primary area of research is investigating the role of non-coding RNA regulation of injury and repair processes within the kidney and cardiovascular system.Currently my group are interested in novel non-coding RNA, their target genes and pathways they target which are associated with renal injury, particular fibrosis and those involved in repair processes. In particular we are interested in dysregulation of non-coding RNA in the cardiovascular system in response to renal dysfunction.For the over 5 years I have been working in the field of small non-coding RNA, miRNAs, involved in renal dysfunction and exploiting this for clinical translation. We have established that dysregulation of several miRNAs, including miR-214, miR-21 and miR-29 family are implicitly involved in renal dysfunction and in particular renal fibrosis. Blockade of miRNA-214 and -21 using genetic or pharmacological agents has the potential to block renal fibrosis and we are pursuing this for clinical translation.Additionally my group has identified a miRNA signature which could potentially be used as a non-invasive biomarker of disease severity in IgA nephropathy (indicated by eGFR and renal biopsy assessment using the Oxford classification) or possibly in the wider CKD population. The signature could also be used to determine patients at high risk of progressive disease. Furthermore, this miRNA signature may represent a novel treatment responsive modifiable biomarker which would permit accelerated testing of new therapeutic interventions.

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