Jonathan Seckl
Moncrieff Arnott Chair of Molecular Medicine
Address
- Street
-
Queen's Medical Research Institute
Edinburgh Bioquarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
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11β-Hydroxysteroid dehydrogenase 1 deficiency prevents PTSD-like memory in young adult mice
In:
Psychoneuroendocrinology, vol. 146, pp. 105945
DOI: https://doi.org/10.1016/j.psyneuen.2022.105945
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland
In:
Translational Psychiatry, vol. 11
DOI: https://doi.org/10.1038/s41398-021-01644-9
Research output: Contribution to Journal › Article (Published) -
Face Coverings and Respiratory Tract Droplet Dispersion
In:
Royal Society Open Science
DOI: https://doi.org/10.1098/rsos.201663
Research output: Contribution to Journal › Article (Published) -
Maternal glucocorticoid metabolism across pregnancy: a potential mechanism underlying fetal glucocorticoid exposure
In:
The Journal of Clinical Endocrinology & Metabolism (JCEM), vol. 105
DOI: https://doi.org/10.1210/clinem/dgz313
Research output: Contribution to Journal › Article (Published) -
Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
In:
Wellcome Open Research , vol. 4, pp. 185
DOI: https://doi.org/10.12688/wellcomeopenres.15538.1
Research output: Contribution to Journal › Article (Published) -
Predictors of Nephrolithiasis, Osteoporosis, and Mortality in Primary Hyperparathyroidism
(9 pages)
In:
The Journal of Clinical Endocrinology & Metabolism (JCEM), vol. 104, pp. 3692-3700
DOI: https://doi.org/10.1210/jc.2018-02483
Research output: Contribution to Journal › Article (Published) -
Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5
In:
Biomolecules, vol. 9, pp. 149
DOI: https://doi.org/10.3390/biom9040149
Research output: Contribution to Journal › Article (Published) -
Predicting outcomes and complications following radioiodine therapy in Graves' thyrotoxicosis
In:
Clinical Endocrinology
DOI: https://doi.org/10.1111/cen.13873
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Presentation, diagnostic assessment and surgical outcomes in primary hyperparathyroidism: a single centre's experience
In:
Endocrine connections
DOI: https://doi.org/10.1530/EC-18-0195
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Midlife stress alters memory and mood-related behaviors in old age: role of locally activated glucocorticoids
In:
Psychoneuroendocrinology, vol. 89
DOI: https://doi.org/10.1016/j.psyneuen.2017.12.018
Research output: Contribution to Journal › Article (Published) -
Cohort Profile: Stratifying Resilience and Depression Longitudinally (STRADL): A questionnaire follow-up of Generation Scotland: Scottish Family Health Study (GS:SFHS)
In:
International Journal of Epidemiology, vol. 47, pp. 13-14g
DOI: https://doi.org/10.1093/ije/dyx115
Research output: Contribution to Journal › Article (Published) -
11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation
In:
Brain, Behavior, and Immunity
DOI: https://doi.org/10.1016/j.bbi.2017.11.015
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Macrophage 11β-HSD1 deficiency promotes inflammatory angiogenesis
In:
Journal of Endocrinology
DOI: https://doi.org/10.1530/JOE-17-0223
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Overexpression of Mineralocorticoid Receptors in the Mouse Forebrain Partly Alleviates the Effects of Chronic Early Life Stress on Spatial Memory, Neurogenesis and Synaptic Function in the Dentate Gyrus
In:
Frontiers in Cellular Neuroscience, vol. 11, pp. 132
DOI: https://doi.org/10.3389/fncel.2017.00132
Research output: Contribution to Journal › Article (Published) -
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)
In:
British Journal of Pharmacology
DOI: https://doi.org/10.1111/bph.13699
Research output: Contribution to Journal › Article (Published) -
Maternal licorice consumption during pregnancy and pubertal, cognitive and psychiatric outcomes in children
In:
American Journal of Epidemiology
DOI: https://doi.org/10.1093/aje/kww172
Research output: Contribution to Journal › Article (Published) -
11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to western diet
In:
Journal of Endocrinology, vol. 232, pp. 273-283
DOI: https://doi.org/10.1530/JOE-16-0578
Research output: Contribution to Journal › Article (Published) -
Dynamic changes in DNA methylation occur during the first year of life in preterm infants
In:
Frontiers in Endocrinology
DOI: https://doi.org/10.3389/fendo.2016.00158
Research output: Contribution to Journal › Article (Published) -
Forebrain-specific transgene rescue of 11β-HSD1 associates with impaired spatial memory and reduced hippocampal BDNF mRNA levels in aged 11β-HSD1 deficient mice
In:
Journal of Neuroendocrinology
DOI: https://doi.org/10.1111/jne.12447
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
(9 pages)
In:
Nature Medicine, vol. 22, pp. 771-779
DOI: https://doi.org/10.1038/nm.4115
Research output: Contribution to Journal › Article (Published)