Janice Bramham

Senior Lecturer and Programme DIrector for MSc Biochemistry

Tel: +44 (0)131 650 4786
Email: Janice.Bramham@ed.ac.uk

Biography

Background

2014-current Lecturer and Programme Director for MSc Biochemistry, University of Edinburgh

2008-2014 Manager of Biophysical Characterisation Facility, CTCB, University of Edinburgh

2004-08 Lecturer, School of Biological Sciences, University of Edinburgh

2002-04 MRC Postdoctoral Research Fellow, School of Chemistry, University of Edinburgh

Qualifications

1993 PhD, St Andrews University

1985 BSc (Hons) Chemistry, University of Warwick

Teaching & PhD supervision

Undergraduate teaching

Current

Undergraduate honours research project supervision

Previous

The Dynamic Cell (2nd year Biology) - Course Organisert, lecturer, tutor, practical leader

Molecules Genes and Cells (1st year Biology) - lecturer, tutor, practical leader

Foundations in Biological Chemistry (1st year Biology) - tutor

Structure and Function of Proteins (3rd year Biology) - lecturer

Biochemical Techniques (4th year Biology ) - lecturer

Structural Biology (4th year Biology) - lecturer, tutor

Biophysical Chemistry (4th year chemistry) - lecturer

Postgraduate teaching

MSc in Biochemistry (Programme Director, Personal Tutor and Lecturer)

Course Organiser and Lecturer for:

> Biochemistry A

> Biochemistry B

> Practical Skills in Biochemistry A

> Practical Skills in Biochemistry B

> Biophysical Chemistry

> Research Project Proposal

MSc Research Project and Dissertation supervision

I am interested in the three-dimensional structures, intrinsic dynamics and interactions of biological macromolecules with the ultimate aim of understanding their structure-function relationships. Current work is focused upon multi-domain, disulphide-bonded, glycoslyated proteins, many of which act as membrane receptors, including:

proteins of the human complement system, which plays an essential role in our immune response to infection;
proteins involved in bone metabolism, in order to understand the molecular basis of bone diseases;
yolk proteins of insect pests, in order to find potential targets for crop management in developing countries

We are determining tertiary structures and investigating specific protein:protein interactions that occur in macromolecular assemblies. The principal technique we employ is high-resolution, multi-dimensional NMR spectroscopy which we complement with other biophysical techniques, such as circular dichroism, dynamic light scattering and isothermal titration calorimetry.

Publications

H-1, C-13 and N-15 resonance assignments of the complement control protein modules of the complement component C7 (4 pages) Oct 2013 In: Biomolecular NMR Assignments, vol. 7, no. 2, pp. 285-288
DOI: https://doi.org/10.1007/s12104-012-9429-3
Contribution to journal › Article (Published)
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins 1 Aug 2012 In: Human Molecular Genetics, vol. 21, no. 15, pp. 3374-3386
DOI: https://doi.org/10.1093/hmg/dds169
Contribution to journal › Article (Published)
The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers and polymers with a folded-back structure in solution 2012 In: Journal of Biological Chemistry, vol. 287, no. 39, pp. 32381-32393
DOI: https://doi.org/10.1074/jbc.M112.393439
Contribution to journal › Article (Published)
A Novel p53 Phosphorylation Site within the MDM2 Ubiquitination Signal : II. A model in which phosphorylation at Ser269 induces a mutant conformation to p53. (14 pages) Nov 2010 In: Journal of Biological Chemistry, vol. 285, no. 48, pp. 37773-37786
DOI: https://doi.org/10.1074/jbc.M110.143107
Contribution to journal › Article (Published)
Building up a picture of C7 on the basis of high-resolution structure of its component modules (1 page) Aug 2010 In: Molecular Immunology, vol. 47, no. 13, pp. 2261-2261
DOI: https://doi.org/10.1016/j.molimm.2010.05.191
Contribution to journal › Meeting abstract (Published)
Actinidine and glucose from the defensive secretion of the stick insect Megacrania nigrosulfurea. (2 pages) Dec 2009 In: Biochemical Systematics and Ecology, vol. 37, no. 6, pp. 759-760
DOI: https://doi.org/10.1016/j.bse.2009.11.002
Contribution to journal › Article (Published)
Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement (13 pages) Jul 2009 In: Journal of Biological Chemistry, vol. 284, no. 29, pp. 19637-19649
DOI: https://doi.org/10.1074/jbc.M901993200
Contribution to journal › Article (Published)
(1)H, (15)N and (13)C resonance assignment of the pair of Factor-I like modules of the complement protein C7 (4 pages) Jun 2009 In: Biomolecular NMR Assignments, vol. 3, no. 1, pp. 49-52
DOI: https://doi.org/10.1007/s12104-008-9139-z
Contribution to journal › Article (Published)
A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity (14 pages) Apr 2009 In: Journal of Biological Chemistry, vol. 284, no. 17, pp. 11517-11530
DOI: https://doi.org/10.1074/jbc.M809294200
Contribution to journal › Article (Published)
A novel combination of chemical cross-linking, mass spectrometry and NMR reveals the architecture of complement component C7 (1 page) Oct 2008 In: Molecular Immunology, vol. 45, no. 16, pp. 4121-4121
DOI: https://doi.org/10.1016/j.molimm.2008.08.076
Contribution to journal › Meeting abstract (Published)
The 3D structure of factor I-like modules from C7 provides structural and functional insights into assembly of the MAC (1 page) Oct 2008 In: Molecular Immunology, vol. 45, no. 16, pp. 4097-4097
DOI: https://doi.org/10.1016/j.molimm.2008.08.007
Contribution to journal › Meeting abstract (Published)
ZZ domain of dystrophin and utrophin : topology and mapping of a beta-dystroglycan interaction site (11 pages) 2007 In: Biochemical Journal, vol. 401, no. 3, pp. 667-77
DOI: https://doi.org/10.1042/BJ20061051
Contribution to journal › Article (Published)
Structural diversity in p160/CREB-binding protein coactivator complexes (9 pages) 2006 In: Journal of Biological Chemistry, vol. 281, no. 21, pp. 14787-95
DOI: https://doi.org/10.1074/jbc.M600237200
Contribution to journal › Article (Published)
Functional insights from the structure of the multifunctional C345C domain of C5 of complement (10 pages) 18 Mar 2005 In: Journal of Biological Chemistry, vol. 280, no. 11, pp. 10636-10645
DOI: https://doi.org/10.1074/jbc.M413126200
Contribution to journal › Article (Published)
Letter to the Editor: H-1, N-15 and C-13 resonance assignments of the C345C domain of the complement component C5 (2 pages) 2004 In: Journal of Biomolecular Nmr, vol. 29, no. 2, pp. 217-218
Contribution to journal › Article (Published)
Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin : calponin (10 pages) 2002 In: Structure, vol. 10, no. 2, pp. 249-258
Contribution to journal › Article (Published)
H-1, N-15 and C-13 resonance assignments of the N-terminal region of calponin (2 pages) 2001 In: Journal of Biomolecular Nmr, vol. 19, no. 2, pp. 189-190
Contribution to journal › Article (Published)
Simultaneous CT-C-13 and VT-N-15 chemical shift labelling: Application to 3D NOESY-CH3NH and 3D C-13,N-15 HSQC-NOESY-CH3NH (7 pages) 2000 In: Journal of Biomolecular Nmr, vol. 18, no. 3, pp. 253-259
Contribution to journal › Article (Published)

This article was published on Jun 13, 2019