Janice Bramham

Senior Lecturer and Programme Director for MSc Biochemistry

Biography

Background

2018 - current    Senior Lecturer and Programme Director for MSc Biochemistry, University of Edinburgh

2014  -2018           Lecturer and Programme Director for MSc Biochemistry, University of Edinburgh

2008 - 2014           Manager of Biophysical Characterisation Facility, CTCB, University of Edinburgh

2004 - 2008           Lecturer, School of Biological Sciences, University of Edinburgh

2002-04    MRC Postdoctoral Research Fellow, School of Chemistry, University of Edinburgh

Qualifications

1993    PhD, St Andrews University

1985    BSc (Hons) Chemistry, University of Warwick

Undergraduate teaching

Current

Undergraduate honours research project supervision

Previous Courses

The Dynamic Cell (2nd year Biology) - Course Organisert, lecturer, tutor, practical leader

Molecules Genes and Cells  (1st year Biology) - lecturer, tutor, practical leader

Foundations in Biological Chemistry (1st year Biology) - tutor

Structure and Function of Proteins (3rd year Biology) - lecturer

Biochemical Techniques (4th year Biology ) - lecturer

Structural Biology (4th year Biology) - lecturer, tutor

Biophysical Chemistry (4th year Chemistry) - lecturer

 

Postgraduate teaching

MSc in Biochemistry  (Programme Director, Senior Lecturer and Cohort Lead)

Course Organiser and Senior Lecturer for the following courses:

Biochemistry A

Biochemistry B

Practical Skills in Biochemistry A

Practical Skills in Biochemistry B

Biophysical Chemistry

Research Project Proposal

 

Course Organiser and Supervisor for MSc Research Project and Dissertation

 

Member of the Examination Boards for MSc in Biochemistry and MSc in Drug Discovery and Translation Biology

Member of the Postgraduate Taught (PGT) Progression Board

Member of the PGT Special Circumstances Committee

Open to PhD supervision enquiries?

Yes

Research summary

I am interested in the three-dimensional structures, intrinsic dynamics and interactions of biological macromolecules with the ultimate aim of understanding their structure-function relationships.  Current work is focused upon multi-domain, disulphide-bonded, glycoslyated proteins, many of which act as membrane receptors, including:

  • proteins of the human complement system, which plays an essential role in our immune response to infection;
  • proteins involved in bone metabolism, in order to understand the molecular basis of bone diseases;
  • yolk proteins of insect pests, in order to find potential targets for crop management in developing countries

We are determining tertiary structures and investigating specific protein:protein interactions that occur in macromolecular assemblies. The principal technique we employ is high-resolution, multi-dimensional NMR spectroscopy which we complement with other biophysical techniques, such as circular dichroism, dynamic light scattering and isothermal titration calorimetry.

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