Janice Bramham
Senior Lecturer and Programme Director for MSc Biochemistry

- Institute of Quantitative Biology, Biochemistry and Biotechnology
Contact details
- Tel: +44 (0)131 650 4786
- Email: Janice.Bramham@ed.ac.uk
Background
2014-current Lecturer and Programme Director for MSc Biochemistry, University of Edinburgh
2008-2014 Manager of Biophysical Characterisation Facility, CTCB, University of Edinburgh
2004-08 Lecturer, School of Biological Sciences, University of Edinburgh
2002-04 MRC Postdoctoral Research Fellow, School of Chemistry, University of Edinburgh
Qualifications
1993 PhD, St Andrews University
1985 BSc (Hons) Chemistry, University of Warwick
Undergraduate teaching
Current
Undergraduate honours research project supervision
Previous
The Dynamic Cell (2nd year Biology) - Course Organisert, lecturer, tutor, practical leader
Molecules Genes and Cells (1st year Biology) - lecturer, tutor, practical leader
Foundations in Biological Chemistry (1st year Biology) - tutor
Structure and Function of Proteins (3rd year Biology) - lecturer
Biochemical Techniques (4th year Biology ) - lecturer
Structural Biology (4th year Biology) - lecturer, tutor
Biophysical Chemistry (4th year chemistry) - lecturer
Postgraduate teaching
MSc in Biochemistry (Programme Director, Personal Tutor and Lecturer)
Course Organiser and Lecturer for:
> Biochemistry A
> Biochemistry B
> Practical Skills in Biochemistry A
> Practical Skills in Biochemistry B
> Biophysical Chemistry
> Research Project Proposal
MSc Research Project and Dissertation supervision
Open to PhD supervision enquiries?
Yes
Research summary
I am interested in the three-dimensional structures, intrinsic dynamics and interactions of biological macromolecules with the ultimate aim of understanding their structure-function relationships. Current work is focused upon multi-domain, disulphide-bonded, glycoslyated proteins, many of which act as membrane receptors, including:
- proteins of the human complement system, which plays an essential role in our immune response to infection;
- proteins involved in bone metabolism, in order to understand the molecular basis of bone diseases;
- yolk proteins of insect pests, in order to find potential targets for crop management in developing countries
We are determining tertiary structures and investigating specific protein:protein interactions that occur in macromolecular assemblies. The principal technique we employ is high-resolution, multi-dimensional NMR spectroscopy which we complement with other biophysical techniques, such as circular dichroism, dynamic light scattering and isothermal titration calorimetry.
-
H-1, C-13 and N-15 resonance assignments of the complement control protein modules of the complement component C7
(4 pages)
In:
Biomolecular NMR Assignments, vol. 7, pp. 285-288
DOI: https://doi.org/10.1007/s12104-012-9429-3
Research output: Contribution to Journal › Article (Published) -
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins
In:
Human Molecular Genetics, vol. 21, pp. 3374-3386
DOI: https://doi.org/10.1093/hmg/dds169
Research output: Contribution to Journal › Article (Published) -
The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers and polymers with a folded-back structure in solution
In:
Journal of Biological Chemistry, vol. 287, pp. 32381-32393
DOI: https://doi.org/10.1074/jbc.M112.393439
Research output: Contribution to Journal › Article (Published) -
A Novel p53 Phosphorylation Site within the MDM2 Ubiquitination Signal: II. A model in which phosphorylation at Ser269 induces a mutant conformation to p53.
(14 pages)
In:
Journal of Biological Chemistry, vol. 285, pp. 37773-37786
DOI: https://doi.org/10.1074/jbc.M110.143107
Research output: Contribution to Journal › Article (Published) -
Building up a picture of C7 on the basis of high-resolution structure of its component modules
(1 page)
In:
Molecular Immunology, vol. 47, pp. 2261-2261
DOI: https://doi.org/10.1016/j.molimm.2010.05.191
Research output: Contribution to Journal › Meeting abstract (Published) -
Actinidine and glucose from the defensive secretion of the stick insect Megacrania nigrosulfurea.
(2 pages)
In:
Biochemical Systematics and Ecology, vol. 37, pp. 759-760
DOI: https://doi.org/10.1016/j.bse.2009.11.002
Research output: Contribution to Journal › Article (Published) -
Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement
(13 pages)
In:
Journal of Biological Chemistry, vol. 284, pp. 19637-19649
DOI: https://doi.org/10.1074/jbc.M901993200
Research output: Contribution to Journal › Article (Published) -
(1)H, (15)N and (13)C resonance assignment of the pair of Factor-I like modules of the complement protein C7
(4 pages)
In:
Biomolecular NMR Assignments, vol. 3, pp. 49-52
DOI: https://doi.org/10.1007/s12104-008-9139-z
Research output: Contribution to Journal › Article (Published) -
A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity
(14 pages)
In:
Journal of Biological Chemistry, vol. 284, pp. 11517-11530
DOI: https://doi.org/10.1074/jbc.M809294200
Research output: Contribution to Journal › Article (Published) -
The 3D structure of factor I-like modules from C7 provides structural and functional insights into assembly of the MAC
(1 page)
In:
Molecular Immunology, vol. 45, pp. 4097-4097
DOI: https://doi.org/10.1016/j.molimm.2008.08.007
Research output: Contribution to Journal › Meeting abstract (Published) -
A novel combination of chemical cross-linking, mass spectrometry and NMR reveals the architecture of complement component C7
(1 page)
In:
Molecular Immunology, vol. 45, pp. 4121-4121
DOI: https://doi.org/10.1016/j.molimm.2008.08.076
Research output: Contribution to Journal › Meeting abstract (Published) -
ZZ domain of dystrophin and utrophin: topology and mapping of a beta-dystroglycan interaction site
(11 pages)
In:
Biochemical Journal, vol. 401, pp. 667-77
DOI: https://doi.org/10.1042/BJ20061051
Research output: Contribution to Journal › Article (Published) -
Structural diversity in p160/CREB-binding protein coactivator complexes
(9 pages)
In:
Journal of Biological Chemistry, vol. 281, pp. 14787-95
DOI: https://doi.org/10.1074/jbc.M600237200
Research output: Contribution to Journal › Article (Published) -
Functional insights from the structure of the multifunctional C345C domain of C5 of complement
(10 pages)
In:
Journal of Biological Chemistry, vol. 280, pp. 10636-10645
DOI: https://doi.org/10.1074/jbc.M413126200
Research output: Contribution to Journal › Article (Published) -
Letter to the Editor: H-1, N-15 and C-13 resonance assignments of the C345C domain of the complement component C5
(2 pages)
In:
Journal of Biomolecular Nmr, vol. 29, pp. 217-218
Research output: Contribution to Journal › Article (Published) -
Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin : calponin
(10 pages)
In:
Structure, vol. 10, pp. 249-258
Research output: Contribution to Journal › Article (Published) -
H-1, N-15 and C-13 resonance assignments of the N-terminal region of calponin
(2 pages)
In:
Journal of Biomolecular Nmr, vol. 19, pp. 189-190
Research output: Contribution to Journal › Article (Published) -
Simultaneous CT-C-13 and VT-N-15 chemical shift labelling: Application to 3D NOESY-CH3NH and 3D C-13,N-15 HSQC-NOESY-CH3NH
(7 pages)
In:
Journal of Biomolecular Nmr, vol. 18, pp. 253-259
Research output: Contribution to Journal › Article (Published)