Guillaume Blin

Lecturer in Stem Cell Biology

Background

  • 2019 : Lecturer in Stem Cell Biology, MRC Centre for Regenerative Medicine, University of Edinburgh, UK.
  • 2017-2019: Senior Research Associate, Lowell Lab, MRC Centre for Regenerative Medicine, University of Edinburgh, UK.
  • 2012-2017: Sir Henry Wellcome post-doctoral  fellow, Lowell Lab, MRC Centre for Regenerative Medicine, University of Edinburgh, UK.
  • 2011 : PhD with Dr. Michel Puceat and Prof. Catherine Picart, Universite Montpellier II
  • 2007: Msc in Biology, Control of cell fate, Universite Montpellier II

Research summary

Quantitative Biology of Pattern Formation

Multicellular organisms are fascinating: they are complex, dynamic, adaptive and display exceptional levels of organisation, yet they come into existence from relatively simple setouts.

Our research aims at identifying general principles explaining how the cells self-organise to form tissues with complex architectures and functions.

By acquiring a quantitative understanding of this question, we wish to advance our ability to engineer novel in vitro models of development and diseases and to inform future strategies for tissue regeneration and repair.

Aims and areas of interest

Our main hypothesis is that patterning is an emergent process. We are particularly interested in understanding how collective interactions occuring at the cellular level may predict the formation of patterns at the tissue level. We also aim to identify general design principles in the formation of tissues which might explain robustness and evolvability of multicellular organisation.

We adopt a forward engineering approach combining mathematical modelling with practical experiments. We use synthetic biology, quantitative imaging and micro-fabrication techniques in order to advance our understanding of patterning and our ability to engineer novel in vitro models of development and diseases. In the process we generate techniques and computational tools which we hope will benefit the broader community.

PickCells: Exploratory Image Analysis for Biology: https://pickcellslab.frama.io/docs/

GitLab projects: https://framagit.org/pickcellslab

View all 16 publications on Research Explorer

Dr. Linus Schumacher, MRC Centre for Regenerative MedicineDr. Thanasis Tsanas, Usher InstituteProf. Dave Robertson, College of Science & Engineering, University of EdinburghDr. Elise Cachat, School of Biological Sciences, University of EdinburghProf. Val Wilson, MRC Centre for Regenerative MedicineDr. Sally Lowell, MRC Centre for Regenerative Medicine