Gillian Gray
Reader
Address
- Street
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The Queen's Medical Research Institute
BioQuarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
Survival following acute myocardial infarction (MI), or heart attack, has increased thanks to efficient intervention to restore blood supply to the myocardium, or heart muscle. However, the myocardium still incurs damage, and as the adult heart does cannot efficiently regenerate new tissue, a fibrous scar is formed that does not contribute to contraction. In the longer term the remaining healthy heart undergoes remodelling while trying to maintain cardiac output, leading to an increased chance of developing of debilitating chronic heart failure. My research is focused primarily on understanding how to limit the loss of contractile tissue that occurs immediately after MI, but in particular the processes involved in infarct healing (inflammation, fibroblast activation & angiogenesis) and how these might be targeted therapeutically to prevent infarct expansion during repair. We also work on development of new imaging techniques to identify vulnerable peri-infarct myocardium and on the mechanisms that support neonatal heart regeneration after injury. see Research in Nutshell video: http://www.nutshell-videos.ed.ac.uk/gillian-gray-myocardial-injury-repai...
Research activities
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The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
In:
eLIFE
DOI: https://doi.org/10.7554/eLife.88080
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Human embryonic stem cell-derived endothelial cell product injection attenuates cardiac remodeling in myocardial infarction
In:
Frontiers in Cardiovascular Medicine
DOI: https://doi.org/10.3389/fcvm.2022.953211
Research output: Contribution to Journal › Article (Published) -
Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvac151
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
DOI: https://doi.org/10.1101/2022.02.20.481222
Research output: › Preprint (Published) -
The Hepatic Compensatory Response to Elevated Systemic Sulfide Promotes Diabetes
In:
Cell Reports
DOI: https://doi.org/10.1016/j.celrep.2021.109958
Research output: Contribution to Journal › Article (Published) -
Positron Emission Tomography Techniques to Measure Active Inflammation, Fibrosis and Angiogenesis in Hypertensive Heart Failure
In:
Frontiers in Cardiovascular Medicine
DOI: https://doi.org/10.3389/fcvm.2021.719031
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Preclinical models of myocardial infarction: from mechanism to translation
In:
British Journal of Pharmacology
DOI: https://doi.org/10.1111/bph.15595
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction
In:
International Journal of Molecular Sciences
DOI: https://doi.org/10.3390/ijms22020969
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells
In:
EBioMedicine, vol. 62
DOI: https://doi.org/10.1016/j.ebiom.2020.103092
Research output: Contribution to Journal › Article (Published) -
Quantification of macrophage-driven inflammation during myocardial infarction with 18F-LW223, a novel TSPO radiotracer with binding independent of the rs6971 human polymorphism
In:
Journal of Nuclear Medicine
DOI: https://doi.org/10.2967/jnumed.120.243600
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy
In:
Journal of Cardiovascular Magnetic Resonance
DOI: https://doi.org/10.1186/s12968-020-00655-7
Research output: Contribution to Journal › Article (Published) -
Mir-96 and miR-183 differentially regulate neonatal and adult post-infarct neovascularisation
In:
JCI Insight, vol. 5
DOI: https://doi.org/10.1172/jci.insight.134888
Research output: Contribution to Journal › Article (Published) -
Eosinophil deficiency promotes aberrant repair and adverse remodelling following acute myocardial infarction
In:
JACC: Basic to Translational Science
DOI: https://doi.org/10.1016/j.jacbts.2020.05.005
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Assessment of myocardial fibrosis activity using 18F-Fluoroproline Positron Emission Tomography (PET) in rat models of cardiovascular disease
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-SCF.26
Research output: Contribution to Journal › Meeting abstract (Published) -
Targeting the main anatomopathological features in animal models of myocardial infarction
In:
Journal of Comparative Pathology
DOI: https://doi.org/10.1016/j.jcpa.2020.01.003
Research output: Contribution to Journal › Literature review (E-pub ahead of print) -
Manganese-enhanced T1 mapping to quantify myocardial viability: validation with 18F-fluorodeoxyglucose positron emission tomography
In:
Scientific Reports, vol. 10
DOI: https://doi.org/10.1038/s41598-020-58716-x
Research output: Contribution to Journal › Article (Published) -
Electrocardiogram-gated Kilohertz Visualisation (EKV) Ultrasound Allows Assessment of Neonatal Cardiac Structural and Functional Maturation and Longitudinal Evaluation of Regeneration After Injury
In:
Ultrasound in Medicine and Biology (UMB)
DOI: https://doi.org/10.1016/j.ultrasmedbio.2019.09.012
Research output: Contribution to Journal › Article (E-pub ahead of print) -
3D angle-independent Doppler and speckle tracking for the myocardium and blood flow
In:
Echo research and practice
DOI: https://doi.org/10.1530/ERP-19-0040
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Single cell transcriptome analyses reveal novel targets modulating cardiac neovascularisation by resident endothelial cells following myocardial infarction
(14 pages)
In:
European Heart Journal, vol. 40, pp. 2507–2520
DOI: https://doi.org/10.1093/eurheartj/ehz305
Research output: Contribution to Journal › Article (Published) -
Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer
In:
PLoS ONE, vol. 14, pp. e0217515
DOI: https://doi.org/10.1371/journal.pone.0217515
Research output: Contribution to Journal › Article (Published)