Gillian Gray
Reader
Address
- Street
-
The Queen's Medical Research Institute
BioQuarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
Survival following acute myocardial infarction (MI), or heart attack, has increased thanks to efficient intervention to restore blood supply to the myocardium, or heart muscle. However, the myocardium still incurs damage, and as the adult heart does cannot efficiently regenerate new tissue, a fibrous scar is formed that does not contribute to contraction. In the longer term the remaining healthy heart undergoes remodelling while trying to maintain cardiac output, leading to an increased chance of developing of debilitating chronic heart failure. My research is focused primarily on understanding how to limit the loss of contractile tissue that occurs immediately after MI, but in particular the processes involved in infarct healing (inflammation, fibroblast activation & angiogenesis) and how these might be targeted therapeutically to prevent infarct expansion during repair. We also work on development of new imaging techniques to identify vulnerable peri-infarct myocardium and on the mechanisms that support neonatal heart regeneration after injury. see Research in Nutshell video: http://www.nutshell-videos.ed.ac.uk/gillian-gray-myocardial-injury-repai...
Research activities
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Assessment of myocardial fibrosis activity using 18F-Fluoroproline Positron Emission Tomography (PET) in rat models of cardiovascular disease
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-SCF.26
Research output: Contribution to Journal › Meeting abstract (Published) -
Targeting the main anatomopathological features in animal models of myocardial infarction
In:
Journal of Comparative Pathology
DOI: https://doi.org/10.1016/j.jcpa.2020.01.003
Research output: Contribution to Journal › Literature review (E-pub ahead of print) -
Manganese-enhanced T1 mapping to quantify myocardial viability: validation with 18F-fluorodeoxyglucose positron emission tomography
In:
Scientific Reports, vol. 10
DOI: https://doi.org/10.1038/s41598-020-58716-x
Research output: Contribution to Journal › Article (Published) -
Electrocardiogram-gated Kilohertz Visualisation (EKV) Ultrasound Allows Assessment of Neonatal Cardiac Structural and Functional Maturation and Longitudinal Evaluation of Regeneration After Injury
In:
Ultrasound in Medicine & Biology
DOI: https://doi.org/10.1016/j.ultrasmedbio.2019.09.012
Research output: Contribution to Journal › Article (E-pub ahead of print) -
3D angle-independent Doppler and speckle tracking for the myocardium and blood flow
In:
Echo research and practice
DOI: https://doi.org/10.1530/ERP-19-0040
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Single cell transcriptome analyses reveal novel targets modulating cardiac neovascularisation by resident endothelial cells following myocardial infarction
In:
European Heart Journal
DOI: https://doi.org/10.1093/eurheartj/ehz305
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer
In:
PLoS ONE, vol. 14, pp. e0217515
DOI: https://doi.org/10.1371/journal.pone.0217515
Research output: Contribution to Journal › Article (Published) -
Enhanced monocyte recruitment and delayed alternative macrophage polarization accompanies impaired repair following myocardial infarction in C57BL/6 compared to BALB/c mice
In:
Clinical & Experimental Immunology
DOI: https://doi.org/10.1111/cei.13330
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart
In:
Journal of Endocrinology
DOI: https://doi.org/10.1530/JOE-18-0666
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Manganese-enhanced T1 mapping in the myocardium of normal and infarcted hearts.
In:
Contrast Media and Molecular Imaging
DOI: https://doi.org/10.1155/2018/9641527
Research output: Contribution to Journal › Article (Published) -
Statistical considerations in reporting cardiovascular research
In:
American Journal of Physiology-Heart and Circulatory Physiology, vol. 315, pp. H303-H313
DOI: https://doi.org/10.1152/ajpheart.00309.2018
Research output: Contribution to Journal › Review article (Published) -
MicroRNA-148b Targets the TGF-β Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing
In:
Molecular Therapy
DOI: https://doi.org/10.1016/j.ymthe.2018.05.002
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Resident cells of the myocardium:more than spectators in cardiac injury, repair and regeneration
(6 pages)
In:
Current opinion in physiology, vol. 1, pp. 46-51
DOI: https://doi.org/10.1016/j.cophys.2017.08.001
Research output: Contribution to Journal › Review article (Published) -
αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
In:
Nature Communications, vol. 8, pp. 1118
DOI: https://doi.org/10.1038/s41467-017-01097-z
Research output: Contribution to Journal › Article (Published) -
A tail of translational regulation
In:
eLIFE, vol. 6
DOI: https://doi.org/10.7554/eLife.29104
Research output: Contribution to Journal › Article (Published) -
11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI
(13 pages)
In:
Journal of Endocrinology, vol. 233, pp. 315-327
DOI: https://doi.org/10.1530/JOE-16-0501
Research output: Contribution to Journal › Article (Published) -
Glucocorticoid receptor alters isovolumetric contraction and restrains cardiac fibrosis
In:
Journal of Endocrinology
DOI: https://doi.org/10.1530/JOE-16-0458
Research output: Contribution to Journal › Article (Published) -
Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium
(13 pages)
In:
Journal of molecular endocrinology, vol. 58, pp. R1-R13
DOI: https://doi.org/10.1530/JME-16-0128
Research output: Contribution to Journal › Article (Published) -
Manganese enhanced MRI of the healthy rat myocardium: a comparison of two clinical-grade manganese based contrast agents
(2 pages)
In:
Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 29, pp. S372-S373
Research output: Contribution to Journal › Meeting abstract (Published) -
Cardiac GR and MR: From Development to Pathology
In:
Trends in Endocrinology and Metabolism, vol. 27, pp. 35-43
DOI: https://doi.org/10.1016/j.tem.2015.10.001
Research output: Contribution to Journal › Literature review (Published)