Gillian Gray
Reader
Address
- Street
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The Queen's Medical Research Institute
BioQuarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
Survival following acute myocardial infarction (MI), or heart attack, has increased thanks to efficient intervention to restore blood supply to the myocardium, or heart muscle. However, the myocardium still incurs damage, and as the adult heart does cannot efficiently regenerate new tissue, a fibrous scar is formed that does not contribute to contraction. In the longer term the remaining healthy heart undergoes remodelling while trying to maintain cardiac output, leading to an increased chance of developing of debilitating chronic heart failure. My research is focused primarily on understanding how to limit the loss of contractile tissue that occurs immediately after MI, but in particular the processes involved in infarct healing (inflammation, fibroblast activation & angiogenesis) and how these might be targeted therapeutically to prevent infarct expansion during repair. We also work on development of new imaging techniques to identify vulnerable peri-infarct myocardium and on the mechanisms that support neonatal heart regeneration after injury. see Research in Nutshell video: http://www.nutshell-videos.ed.ac.uk/gillian-gray-myocardial-injury-repai...
Research activities
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Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells
In:
EBioMedicine, vol. 62
DOI: https://doi.org/10.1016/j.ebiom.2020.103092
Research output: Contribution to Journal › Article (Published) -
Quantification of macrophage-driven inflammation during myocardial infarction with 18F-LW223, a novel TSPO radiotracer with binding independent of the rs6971 human polymorphism
In:
Journal of Nuclear Medicine
DOI: https://doi.org/10.2967/jnumed.120.243600
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy
In:
Journal of Cardiovascular Magnetic Resonance
DOI: https://doi.org/10.1186/s12968-020-00655-7
Research output: Contribution to Journal › Article (Published) -
Mir-96 and miR-183 differentially regulate neonatal and adult post-infarct neovascularisation
In:
JCI Insight, vol. 5
DOI: https://doi.org/10.1172/jci.insight.134888
Research output: Contribution to Journal › Article (Published) -
Eosinophil deficiency promotes aberrant repair and adverse remodelling following acute myocardial infarction
In:
JACC: Basic to Translational Science
DOI: https://doi.org/10.1016/j.jacbts.2020.05.005
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Assessment of myocardial fibrosis activity using 18F-Fluoroproline Positron Emission Tomography (PET) in rat models of cardiovascular disease
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-SCF.26
Research output: Contribution to Journal › Meeting abstract (Published) -
Targeting the main anatomopathological features in animal models of myocardial infarction
In:
Journal of Comparative Pathology
DOI: https://doi.org/10.1016/j.jcpa.2020.01.003
Research output: Contribution to Journal › Literature review (E-pub ahead of print) -
Manganese-enhanced T1 mapping to quantify myocardial viability: validation with 18F-fluorodeoxyglucose positron emission tomography
In:
Scientific Reports, vol. 10
DOI: https://doi.org/10.1038/s41598-020-58716-x
Research output: Contribution to Journal › Article (Published) -
Electrocardiogram-gated Kilohertz Visualisation (EKV) Ultrasound Allows Assessment of Neonatal Cardiac Structural and Functional Maturation and Longitudinal Evaluation of Regeneration After Injury
In:
Ultrasound in Medicine & Biology
DOI: https://doi.org/10.1016/j.ultrasmedbio.2019.09.012
Research output: Contribution to Journal › Article (E-pub ahead of print) -
3D angle-independent Doppler and speckle tracking for the myocardium and blood flow
In:
Echo research and practice
DOI: https://doi.org/10.1530/ERP-19-0040
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Single cell transcriptome analyses reveal novel targets modulating cardiac neovascularisation by resident endothelial cells following myocardial infarction
In:
European Heart Journal
DOI: https://doi.org/10.1093/eurheartj/ehz305
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer
In:
PLoS ONE, vol. 14, pp. e0217515
DOI: https://doi.org/10.1371/journal.pone.0217515
Research output: Contribution to Journal › Article (Published) -
Enhanced monocyte recruitment and delayed alternative macrophage polarization accompanies impaired repair following myocardial infarction in C57BL/6 compared to BALB/c mice
In:
Clinical & Experimental Immunology
DOI: https://doi.org/10.1111/cei.13330
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart
In:
Journal of Endocrinology
DOI: https://doi.org/10.1530/JOE-18-0666
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Manganese-enhanced T1 mapping in the myocardium of normal and infarcted hearts.
In:
Contrast Media and Molecular Imaging
DOI: https://doi.org/10.1155/2018/9641527
Research output: Contribution to Journal › Article (Published) -
Statistical considerations in reporting cardiovascular research
In:
American Journal of Physiology-Heart and Circulatory Physiology, vol. 315, pp. H303-H313
DOI: https://doi.org/10.1152/ajpheart.00309.2018
Research output: Contribution to Journal › Review article (Published) -
MicroRNA-148b Targets the TGF-β Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing
In:
Molecular Therapy
DOI: https://doi.org/10.1016/j.ymthe.2018.05.002
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Resident cells of the myocardium:more than spectators in cardiac injury, repair and regeneration
(6 pages)
In:
Current opinion in physiology, vol. 1, pp. 46-51
DOI: https://doi.org/10.1016/j.cophys.2017.08.001
Research output: Contribution to Journal › Review article (Published) -
αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
In:
Nature Communications, vol. 8, pp. 1118
DOI: https://doi.org/10.1038/s41467-017-01097-z
Research output: Contribution to Journal › Article (Published) -
A tail of translational regulation
In:
eLIFE, vol. 6
DOI: https://doi.org/10.7554/eLife.29104
Research output: Contribution to Journal › Article (Published)