Gareth Roberts
PostDoc
Contact details
- Email: gareth.roberts@ed.ac.uk
Address
- Street
-
Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive - City
- Edinburgh
- Post code
- EH16 4UU
Background
My research focuses on engineering synthetic transcription factors for cellular reprogramming applications.
-
Dissecting OCT4 defines the role of nucleosome binding in pluripotency
(12 pages)
In:
Nature Cell Biology, vol. 23, pp. 834-845
DOI: https://doi.org/10.1038/s41556-021-00727-5
Research output: Contribution to Journal › Article (Published) -
Replication | DNA modification, restriction endonucleases: Type I enzymes
DOI: https://doi.org/10.1016/b978-0-12-819460-7.00101-8
Research output: › Chapter (Published) -
A model for the evolution of prokaryotic DNA restriction-modification systems based upon the structural malleability of Type I restriction-modification enzymes
(14 pages)
In:
Nucleic Acids Research, vol. 46, pp. 9067-9080
DOI: https://doi.org/10.1093/nar/gky760
Research output: Contribution to Journal › Article (Published) -
DNA target recognition domains in the Type I restriction and modification systems of Staphylococcus aureus
In:
Nucleic Acids Research
DOI: https://doi.org/10.1093/nar/gkx067
Research output: Contribution to Journal › Article (Published) -
The evolutionary pathway from a biologically inactive polypeptide sequence to a folded, active structural mimic of DNA
(15 pages)
In:
Nucleic Acids Research, vol. 44, pp. 4289-303
DOI: https://doi.org/10.1093/nar/gkw234
Research output: Contribution to Journal › Article (Published) -
The Type I Restriction Enzymes as Barriers to Horizontal Gene Transfer: Determination of the DNA Target Sequences Recognised by Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complexes 133/ST771 and 398
(17 pages)
DOI: https://doi.org/10.1007/978-3-319-32189-9_7
Research output: › Chapter (Published) -
ArdA proteins from different mobile genetic elements can bind to the EcoKI Type i DNA methyltransferase of E. coli K12
(7 pages)
In:
BBA - Proteins and Proteomics, vol. 1844, pp. 505-511
DOI: https://doi.org/10.1016/j.bbapap.2013.12.008
Research output: Contribution to Journal › Article (Published) -
Impact of target site distribution for Type I restriction enzymes on the evolution of methicillin-resistant Staphylococcus aureus (MRSA) populations
(13 pages)
In:
Nucleic Acids Research, vol. 41, pp. 7472-7484
DOI: https://doi.org/10.1093/nar/gkt535
Research output: Contribution to Journal › Article (Published) -
Mutations of the domain forming the dimeric interface of the ArdA protein affect dimerisation and antimodification activity but not antirestriction activity
In:
The FEBS Journal, vol. 280, pp. 4903–4914
DOI: https://doi.org/10.1111/febs.12467
Research output: Contribution to Journal › Article (Published) -
Mutations of the domain forming the dimeric interface of the ArdA protein affect dimerization and antimodification activity but not antirestriction activity
(11 pages)
In:
The FEBS Journal, vol. 280, pp. 4903-4914
DOI: https://doi.org/10.1111/febs.12467
Research output: Contribution to Journal › Article (Published) -
DNA Electrophoresis: Historical and Theoretical Perspectives
DOI: https://doi.org/10.1007/978-1-62703-565-1_1
Research output: › Other chapter contribution (Published) -
Structure and operation of the DNA-translocating type I DNA restriction enzymes
(13 pages)
In:
Genes and Development, vol. 26, pp. 92-104
DOI: https://doi.org/10.1101/gad.179085.111
Research output: Contribution to Journal › Article (Published) -
Exploring the DNA mimicry of the Ocr protein of phage T7
In:
Nucleic Acids Research, vol. 40, pp. 8129-8143
DOI: https://doi.org/10.1093/nar/gks516
Research output: Contribution to Journal › Article (Published) -
Removal of a frameshift between the hsdM and hsdS genes of the EcoKI Type IA DNA restriction and modification system produces a new type of system and links the different families of Type I systems
(9 pages)
In:
Nucleic Acids Research, vol. 40, pp. 10916-24
DOI: https://doi.org/10.1093/nar/gks876
Research output: Contribution to Journal › Article (Published) -
An investigation of the structural requirements for ATP hydrolysis and DNA cleavage by the EcoKI Type I DNA restriction and modification enzyme
(10 pages)
In:
Nucleic Acids Research, vol. 39, pp. 7667-7676
DOI: https://doi.org/10.1093/nar/gkr480
Research output: Contribution to Journal › Article (Published) -
Fusion of GFP to the M.EcoKI DNA methyltransferase produces a new probe of Type I DNA restriction and modification enzymes
(6 pages)
In:
Biochemical and Biophysical Research Communications, vol. 398, pp. 254-259
DOI: https://doi.org/10.1016/j.bbrc.2010.06.069
Research output: Contribution to Journal › Article (Published) -
The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro
(15 pages)
In:
Nucleic Acids Research, vol. 38, pp. 1723-1737
DOI: https://doi.org/10.1093/nar/gkp1144
Research output: Contribution to Journal › Article (Published) -
Dissection of the DNA Mimicry of the Bacteriophage T7 Ocr Protein using Chemical Modification
(12 pages)
In:
Journal of Molecular Biology, vol. 391, pp. 565-576
DOI: https://doi.org/10.1016/j.jmb.2009.06.020
Research output: Contribution to Journal › Article (Published) -
Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance
(11 pages)
In:
Nucleic Acids Research, vol. 37, pp. 4887-4897
DOI: https://doi.org/10.1093/nar/gkp478
Research output: Contribution to Journal › Article (Published) -
Extracellularly truncated desmoglein 1 compromises desmosomes in MDCK cells
(9 pages)
In:
Molecular Membrane Biology, vol. 17, pp. 175-183
DOI: https://doi.org/10.1080/09687680010002238
Research output: Contribution to Journal › Article (E-pub ahead of print)