Dr Susana Muñoz Maniega
- Centre for Clinical Brain Sciences
- Edinburgh Imaging
- Row Fogo Centre
Contact details
- Email: s.m.maniega@ed.ac.uk
Current PhD students supervised
Miss Angela Jochems
Research summary
I employ diffusion MRI for the measurement of white matter integrity and for the reconstruction of white matter pathways, the “wiring” in the brain.
My major interest is the use of quantitative MRI to study in vivo the effects of cerebrovascular disease, and ageing in general, on the brain's white matter. I process and analyse the imaging data from the Lothian Birth Cohort 1936 (LBC1936), a longitudinal study of cognitive ageing.
LBC1936 has a wide range of variables: genome-wide genotyping, demographics, psycho-social and lifestyle factors, cognitive functions, medical history and examinations, biomarkers (from blood and urine) and a detailed structural MRI brain scan. The imaging side of the project has a specific focus on finding how the white matter of the brain becomes damaged and what relationship white matter damage has with age-related cognitive decline.
I also collaborate on the MRI image processing and analysis of other research projects in cerebrovascular disease, such as the Mild Stroke Study 3 and INVESTIGATE@SVDs
Project activity
“Lothian Birth Cohort 1936” longitudinal study, funded by Age UK and the Medical Research Council.
https://www.ed.ac.uk/lothian-birth-cohorts
Small Vessel Diseases (SVDs).
https://www.ed.ac.uk/clinical-brain-sciences/research/row-fogo-centre/our-research/research-projects
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Birth weight is associated with brain tissue volumes seven decades later but not with MRI markers of brain ageing
In:
NeuroImage: Clinical
Research output: Contribution to Journal › Article (Accepted/In press) -
Early life predictors of late life cerebral small vessel disease in four prospective cohort studies
In:
Brain
Research output: Contribution to Journal › Article (Accepted/In press) -
Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease
In:
Neurobiology of Aging, vol. 106, pp. 130-138
DOI: https://doi.org/10.1016/j.neurobiolaging.2021.06.013
Research output: Contribution to Journal › Article (Published) -
Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936
In:
Translational Psychiatry
Research output: Contribution to Journal › Article (Accepted/In press) -
Comparison of structural MRI brain measures between 1.5 and 3T: Data from the Lothian Birth Cohort 1936
In:
Human Brain Mapping
DOI: https://doi.org/10.1002/hbm.25473
Research output: Contribution to Journal › Article (E-pub ahead of print)