Dr Susana Muñoz Maniega
- Centre for Clinical Brain Sciences
- Edinburgh Imaging
- Row Fogo Centre
Contact details
- Email: s.m.maniega@ed.ac.uk
Current PhD students supervised
Miss Angela Jochems
Research summary
I employ diffusion MRI for the measurement of white matter integrity and for the reconstruction of white matter pathways, the “wiring” in the brain.
My major interest is the use of quantitative MRI to study in vivo the effects of cerebrovascular disease, and ageing in general, on the brain's white matter. I process and analyse the imaging data from the Lothian Birth Cohort 1936 (LBC1936), a longitudinal study of cognitive ageing.
LBC1936 has a wide range of variables: genome-wide genotyping, demographics, psycho-social and lifestyle factors, cognitive functions, medical history and examinations, biomarkers (from blood and urine) and a detailed structural MRI brain scan. The imaging side of the project has a specific focus on finding how the white matter of the brain becomes damaged and what relationship white matter damage has with age-related cognitive decline.
I also collaborate on the MRI image processing and analysis of other research projects in cerebrovascular disease, such as the Mild Stroke Study 3 and INVESTIGATE@SVDs
Project activity
“Lothian Birth Cohort 1936” longitudinal study, funded by Age UK and the Medical Research Council.
https://www.ed.ac.uk/lothian-birth-cohorts
Small Vessel Diseases (SVDs).
https://www.ed.ac.uk/clinical-brain-sciences/research/row-fogo-centre/our-research/research-projects
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Blood-based epigenome-wide analyses of cognitive abilities
In:
Genome Biology, vol. 23
DOI: https://doi.org/10.1186/s13059-021-02596-5
Research output: Contribution to Journal › Article (Published) -
Early life predictors of late life cerebral small vessel disease in four prospective cohort studies
In:
Brain, vol. 144
DOI: https://doi.org/10.1093/brain/awab331
Research output: Contribution to Journal › Article (Published) -
DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging
In:
Neurology, pp. 10.1212/WNL.0000000000012997
DOI: https://doi.org/10.1212/WNL.0000000000012997
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort
In:
Neurobiology of Aging, vol. 105, pp. 2021.02.02.21250986
DOI: https://doi.org/10.1016/j.neurobiolaging.2021.04.007
Research output: Contribution to Journal › Article (Published) -
Comparison of structural MRI brain measures between 1.5 and 3T: Data from the Lothian Birth Cohort 1936
In:
Human Brain Mapping, pp. 3905-3921
DOI: https://doi.org/10.1002/hbm.25473
Research output: Contribution to Journal › Article (Published)