David Hay
Group Leader and Professor of Tissue Engineering
- Centre for Regenerative Medicine
- Institute for Regeneration and Repair
Contact details
- Tel: 0131 651 9500
- Email: david.hay@ed.ac.uk
Address
- Street
-
Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive - City
- Edinburgh
- Post code
- EH16 4UU
Background
- Group leader of the Pluripotent Stem Cell Hepatocyte Development team
- Expert in cell differentiation and tissue engineering
- Over 15 years’ experience in pluripotent stem cell biology
- Experience of start-up company formation and securing seed funding
- PhD 2000 and BSc (Hons) 1996, University of St Andrews, UK
Open to PhD supervision enquiries?
Yes
Current PhD students supervised
- Matthew Sinton (PhD Student shared with BHF CVR)
- Angus Marks (PhD Student shared with Chemistry)
- Sharmin Alhaque (PhD Student shared with Brunel University)
- Gregor Skeldon (PhD Student shared with Strathclyde University)
Research summary
Liver Tissue Development and Engineering
The liver plays a vital role in human health, including the detoxification of foreign substances. We use stem cells to grow liver tissue in the laboratory. The stem cells we use are called human embryonic stem cells and induced pluripotent stem cells. The attraction of using these cell populations is their indefinite growth in the lab and their ability to form all the cells found in the human body. We have developed reliable methods for building human liver tissue. Encouragingly, it behaves in a similar way to the liver found in the human body. We believe our liver tissue has an important part to play in improving human drug development and repurposing; modelling human disease and in the future may provide an alternative source of human tissue to treat failing human liver function.
Knowledge exchange
-
Chemically cross-linked hydrogels from repetitive protein arrays
(20 pages)
In:
Journal of Structural Biology
DOI: https://doi.org/10.1016/j.jsb.2023.107981
Research output: Contribution to Journal › Article (Accepted/In press) -
Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells
In:
Journal of Hepatology
DOI: https://doi.org/10.1016/j.jhep.2022.07.009
Research output: Contribution to Journal › Article (Published) -
HIV- 1 lentivirus tethering to the genome is associated with transcription factor binding sites found in genes that favour virus survival.
In:
Gene Therapy
DOI: https://doi.org/10.1038/s41434-022-00335-4
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: Cohort study of 151,141 singleton pregnancies
In:
BMJ Paediatrics Open
DOI: https://doi.org/10.1136/bmjopen-2020-048092
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Nuclear factor programming improves stem-cell-derived hepatocyte phenotype
In:
Cell Stem Cell
DOI: https://doi.org/10.1016/j.stem.2022.04.009
Research output: Contribution to Journal › Article (Published) -
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease
In:
Cell Stem Cell
DOI: https://doi.org/10.1016/j.stem.2022.02.006
Research output: Contribution to Journal › Article (Published) -
Pluripotent Stem Cell-Derived Hepatocytes Inhibit T Cell Proliferation In Vitro through Tryptophan Starvation
In:
Cells
DOI: https://doi.org/10.3390/cells11010024
Research output: Contribution to Journal › Article (Published) -
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure
In:
iScience
DOI: https://doi.org/10.1016/j.isci.2021.102552
Research output: Contribution to Journal › Article (Published) -
Protocol for automated production of human stem cell derived liver spheres
In:
STAR Protocols
DOI: https://doi.org/10.1016/j.xpro.2021.100502
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Modelling human hepatic steatosis in pluripotent stem cell-derived hepatocytes
In:
STAR Protocols
DOI: https://doi.org/10.1016/j.xpro.2021.100493
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Mathematical modelling of oxygen gradients in stem cell-derived liver tissue
(16 pages)
In:
PLoS ONE, vol. 16
DOI: https://doi.org/10.1371/journal.pone.0244070
Research output: Contribution to Journal › Article (Published) -
A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis
In:
iScience, vol. 24
DOI: https://doi.org/10.1016/j.isci.2020.101931
Research output: Contribution to Journal › Article (Published) -
Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells
In:
EXCLI, vol. 19
DOI: https://doi.org/10.17179/excli2020-2934
Research output: Contribution to Journal › Article (Published) -
Over-the-counter analgesics during pregnancy: a comprehensive review of global prevalence and offspring safety
In:
Human Reproduction Update
DOI: https://doi.org/10.1093/humupd/dmaa042
Research output: Contribution to Journal › Article (Published) -
Development of a cost effective automated platform to produce human liver spheroids for basic and applied research
In:
Biofabrication, vol. 13
DOI: https://doi.org/10.1088/1758-5090/abbdb2
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Human PSC-derived hepatocytes express low levels of viral pathogen recognition receptors, but are capable of mounting an effective innate immune response
(18 pages)
In:
International Journal of Molecular Sciences, vol. 21
DOI: https://doi.org/10.3390/ijms21113831
Research output: Contribution to Journal › Article (Published) -
Introducing Point Mutations into Human Pluripotent Stem Cells using Seamless Genome Editing
In:
Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/61152
Research output: Contribution to Journal › Article (Published) -
Hepatic Progenitor Specification from Pluripotent Stem Cells Using a Defined Differentiation System
(8 pages)
In:
Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/6125
Research output: Contribution to Journal › Article (Published) -
Chapter 40 Liver stem cells
Research output: › Chapter (Published) -
The Parliamentary Office of Science and Technology Notes: 3D bioprinting in medicine
In:
The Parliamentary Office of Science and Technology Notes
Research output: Contribution to Journal › Article (Published)
We work collaboratively with a number of groups in Edinburgh:
Stuart Forbes, Ian Wilmut, Bruno Peault, Anura Rambukkana, Jim Ross, Mark Bradley, Anthony Callanan, Mandy Drake, Colin Campbell, Carsten Hansen
We collaborate with other researchers in the UK and overseas:
- Fiona Watt, Anil Dhawan, and Giovanna Lombardi, King’s College London
- Jan Hengstler and Patricio Godoy, University of Dortmund
- Lijian Hui, Shanghai Institutes for Biological Sciences
- Ron Hay and Roland Wolf, University of Dundee
- Cliona O’Farrelly, Trinity College Dublin
- Philip Newsome, University of Birmingham
- Jo Mountford, University of Glasgow
- Will Shu, Strathclyde University
- Stephen Strom, Karolinska Institute
- Ludovic Vallier, Cambridge University
Our industry partners include:
- Ruchi Sharma, Stemnovate
- Kristian Tryggvason, Biolamina
- Dominic Williams, Astra Zeneca
- Charis Segeritz-Walko – StemCell Technologies