David Hay
Group Leader and Professor of Tissue Engineering
- Centre for Regenerative Medicine
- Institute for Regeneration and Repair
Contact details
- Tel: 0131 651 9500
- Email: david.hay@ed.ac.uk
Address
- Street
-
Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive - City
- Edinburgh
- Post code
- EH16 4UU
Background
- Group leader of the Pluripotent Stem Cell Hepatocyte Development team
- Expert in cell differentiation and tissue engineering
- Over 15 years’ experience in pluripotent stem cell biology
- Experience of start-up company formation and securing seed funding
- PhD 2000 and BSc (Hons) 1996, University of St Andrews, UK
Open to PhD supervision enquiries?
Yes
Current PhD students supervised
- Matthew Sinton (PhD Student shared with BHF CVR)
- Angus Marks (PhD Student shared with Chemistry)
- Sharmin Alhaque (PhD Student shared with Brunel University)
- Gregor Skeldon (PhD Student shared with Strathclyde University)
Research summary
Liver Tissue Development and Engineering
The liver plays a vital role in human health, including the detoxification of foreign substances. We use stem cells to grow liver tissue in the laboratory. The stem cells we use are called human embryonic stem cells and induced pluripotent stem cells. The attraction of using these cell populations is their indefinite growth in the lab and their ability to form all the cells found in the human body. We have developed reliable methods for building human liver tissue. Encouragingly, it behaves in a similar way to the liver found in the human body. We believe our liver tissue has an important part to play in improving human drug development and repurposing; modelling human disease and in the future may provide an alternative source of human tissue to treat failing human liver function.
Knowledge exchange
-
Over-the-counter analgesics during pregnancy: a comprehensive review of global prevalence and offspring safety
In:
Human Reproduction Update
Research output: Contribution to Journal › Article (Accepted/In press) -
Human PSC-derived hepatocytes express low levels of viral pathogen recognition receptors but are capable of mounting an effective innate immune response
In:
International Journal of Molecular Sciences
Research output: Contribution to Journal › Article (Accepted/In press) -
Introducing Point Mutations into Human Pluripotent Stem Cells using Seamless Genome Editing
In:
Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/61152
Research output: Contribution to Journal › Article (Published) -
Chapter 39 Liver stem cells
Research output: › Chapter (Published) -
The Parliamentary Office of Science and Technology Notes: 3D bioprinting in medicine
In:
The Parliamentary Office of Science and Technology Notes
Research output: Contribution to Journal › Article (Published) -
Hepatic Progenitor Specification from Pluripotent Stem Cells Using a Defined Differentiation System
In:
Journal of Visualized Experiments (JoVE)
Research output: Contribution to Journal › Article (Accepted/In press) -
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
In:
Archives of toxicology
Research output: Contribution to Journal › Article (Published) -
Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells
In:
PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0221762
Research output: Contribution to Journal › Article (Published) -
Serum Free Production of Three-Dimensional Human Hepatospheres from Pluripotent Stem Cells
In:
Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/59965
Research output: Contribution to Journal › Article (Published) -
Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome
In:
Clinical Epigenetics, vol. 11
DOI: https://doi.org/10.1186/s13148-019-0702-5
Research output: Contribution to Journal › Article (Published) -
Multiomics analyses of HNF4a protein domain function during human pluripotent stem cell differentiation
In:
iScience
DOI: https://doi.org/10.1016/j.isci.2019.05.028
Research output: Contribution to Journal › Article (Published) -
Blended electrospinning with human liver extracellular matrix for engineering new hepatic microenvironments
In:
Scientific Reports, vol. 9
DOI: https://doi.org/10.1038/s41598-019-42627-7
Research output: Contribution to Journal › Article (Published) -
3D Tissue Models for Toxicology
Research output: › Chapter (peer-reviewed) (Published) -
The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae
In:
Current Biology
DOI: https://doi.org/10.1016/j.cub.2018.11.066
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Combining stem cell-derived hepatocytes with impedance sensing to better predict human drug toxicity
In:
Expert opinion on drug metabolism & toxicology
DOI: https://doi.org/10.1080/17425255.2019.1558208
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Methylcellulose as a scaffold in the culture of liver-organoids for the potential of treating acute live failure
In:
Cell and Gene Therapy Insights, vol. 4, pp. 1087-1103
DOI: https://doi.org/10.18609/cgti.2018.111
Research output: Contribution to Journal › Article (Published) -
Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop
In:
Regenerative medicine, vol. 13, pp. 935-944
DOI: https://doi.org/10.2217/rme-2018-0120
Research output: Contribution to Journal › Article (Published) -
3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo
In:
Archives of toxicology, vol. 92, pp. 3117–3129
DOI: https://doi.org/10.1007/s00204-018-2280-2
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Semi-automated Production of Hepatocyte like Cells from Pluripotent Stem Cells
In:
Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/57995
Research output: Contribution to Journal › Article (Published) -
Designer human tissue: Coming to a lab near you
In:
Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 373
DOI: https://doi.org/10.1098/rstb.2017.0212
Research output: Contribution to Journal › Article (Published)
We work collaboratively with a number of groups in Edinburgh:
Stuart Forbes, Ian Wilmut, Bruno Peault, Anura Rambukkana, Jim Ross, Mark Bradley, Anthony Callanan, Mandy Drake, Colin Campbell, Carsten Hansen
We collaborate with other researchers in the UK and overseas:
- Fiona Watt, Anil Dhawan, and Giovanna Lombardi, King’s College London
- Jan Hengstler and Patricio Godoy, University of Dortmund
- Lijian Hui, Shanghai Institutes for Biological Sciences
- Ron Hay and Roland Wolf, University of Dundee
- Cliona O’Farrelly, Trinity College Dublin
- Philip Newsome, University of Birmingham
- Jo Mountford, University of Glasgow
- Will Shu, Strathclyde University
- Stephen Strom, Karolinska Institute
- Ludovic Vallier, Cambridge University
Our industry partners include:
- Ruchi Sharma, Stemnovate
- Kristian Tryggvason, Biolamina
- Dominic Williams, Astra Zeneca
- Charis Segeritz-Walko – StemCell Technologies