David Hay | The University of Edinburgh

Group Leader and Professor of Tissue Engineering

Centre for Regenerative Medicine
Institute for Regeneration and Repair

Tel: 0131 651 9500
Email: david.hay@ed.ac.uk

Street: Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive
City: Edinburgh
Post code: EH16 4UU

Biography

Background

Group leader of the Pluripotent Stem Cell Hepatocyte Development team
Expert in cell differentiation and tissue engineering
Over 15 years’ experience in pluripotent stem cell biology
Experience of start-up company formation and securing seed funding
PhD 2000 and BSc (Hons) 1996, University of St Andrews, UK

Teaching & PhD supervision

Open to PhD supervision enquiries?

Yes

Current PhD students supervised

Matthew Sinton (PhD Student shared with BHF CVR)
Angus Marks (PhD Student shared with Chemistry)
Sharmin Alhaque (PhD Student shared with Brunel University)
Gregor Skeldon (PhD Student shared with Strathclyde University)

Research

Research summary

Liver Tissue Development and Engineering

The liver plays a vital role in human health, including the detoxification of foreign substances. We use stem cells to grow liver tissue in the laboratory. The stem cells we use are called human embryonic stem cells and induced pluripotent stem cells. The attraction of using these cell populations is their indefinite growth in the lab and their ability to form all the cells found in the human body. We have developed reliable methods for building human liver tissue. Encouragingly, it behaves in a similar way to the liver found in the human body. We believe our liver tissue has an important part to play in improving human drug development and repurposing; modelling human disease and in the future may provide an alternative source of human tissue to treat failing human liver function.

Affiliated research centres

Projects

Project activity

HUMAN - health and the understanding of metabolism, aging and nutrition

UKRMP II disease systems

UKRMP (UK Regenerative Medicine Platform)

Publications

Human PSC-derived hepatocytes express low levels of viral pathogen recognition receptors but are capable of mounting an effective innate immune response 24 May 2020 In: International Journal of Molecular Sciences
Research output: Contribution to Journal › Article (Accepted/In press)
Introducing Point Mutations into Human Pluripotent Stem Cells using Seamless Genome Editing 10 May 2020 In: Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/61152
Research output: Contribution to Journal › Article (Published)
Chapter 39 Liver stem cells 30 Mar 2020
Research output: › Chapter (Published)
The Parliamentary Office of Science and Technology Notes: 3D bioprinting in medicine 13 Mar 2020 In: The Parliamentary Office of Science and Technology Notes
Research output: Contribution to Journal › Article (Published)
Hepatic Progenitor Specification from Pluripotent Stem Cells Using a Defined Differentiation System 3 Mar 2020 In: Journal of Visualized Experiments (JoVE)
Research output: Contribution to Journal › Article (Accepted/In press)
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease 9 Jan 2020 In: Archives of toxicology
Research output: Contribution to Journal › Article (Published)
Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells 29 Aug 2019 In: PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0221762
Research output: Contribution to Journal › Article (Published)
Serum Free Production of Three-Dimensional Human Hepatospheres from Pluripotent Stem Cells 20 Jul 2019 In: Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/59965
Research output: Contribution to Journal › Article (Published)
Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome 18 Jul 2019 In: Clinical epigenetics, vol. 11
DOI: https://doi.org/10.1186/s13148-019-0702-5
Research output: Contribution to Journal › Article (Published)
Multiomics analyses of HNF4a protein domain function during human pluripotent stem cell differentiation 24 May 2019 In: iScience
DOI: https://doi.org/10.1016/j.isci.2019.05.028
Research output: Contribution to Journal › Article (Published)
Blended electrospinning with human liver extracellular matrix for engineering new hepatic microenvironments 18 Apr 2019 In: Scientific Reports, vol. 9
DOI: https://doi.org/10.1038/s41598-019-42627-7
Research output: Contribution to Journal › Article (Published)
3D Tissue Models for Toxicology 3 Jan 2019
Research output: › Chapter (peer-reviewed) (Published)
The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae 27 Dec 2018 In: Current Biology
DOI: https://doi.org/10.1016/j.cub.2018.11.066
Research output: Contribution to Journal › Article (E-pub ahead of print)
Combining stem cell-derived hepatocytes with impedance sensing to better predict human drug toxicity 20 Dec 2018 In: Expert opinion on drug metabolism & toxicology
DOI: https://doi.org/10.1080/17425255.2019.1558208
Research output: Contribution to Journal › Article (E-pub ahead of print)
Methylcellulose as a scaffold in the culture of liver-organoids for the potential of treating acute live failure 18 Dec 2018 In: Cell and Gene Therapy Insights, vol. 4, pp. 1087-1103
DOI: https://doi.org/10.18609/cgti.2018.111
Research output: Contribution to Journal › Article (Published)
Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop 1 Dec 2018 In: Regenerative medicine, vol. 13, pp. 935-944
DOI: https://doi.org/10.2217/rme-2018-0120
Research output: Contribution to Journal › Article (Published)
3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo 28 Aug 2018 In: Archives of toxicology, vol. 92, pp. 3117–3129
DOI: https://doi.org/10.1007/s00204-018-2280-2
Research output: Contribution to Journal › Article (E-pub ahead of print)
Semi-automated Production of Hepatocyte like Cells from Pluripotent Stem Cells 27 Jul 2018 In: Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/57995
Research output: Contribution to Journal › Article (Published)
Designer human tissue: Coming to a lab near you 5 Jul 2018 In: Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 373
DOI: https://doi.org/10.1098/rstb.2017.0212
Research output: Contribution to Journal › Article (Published)
A human iPSC line capable of differentiating into functional macrophages expressing ZsGreen: a tool for the study and in vivo tracking of therapeutic cells (9 pages) 5 Jul 2018 In: Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 373
DOI: https://doi.org/10.1098/rstb.2017.0219
Research output: Contribution to Journal › Article (Published)

View all 120 publications on Research Explorer

Funders

Astellas Institute for Regenerative Medicine

Novo Nordisk

Collaborators

We work collaboratively with a number of groups in Edinburgh:

Stuart Forbes, Ian Wilmut, Bruno Peault, Anura Rambukkana, Jim Ross, Mark Bradley, Anthony Callanan, Mandy Drake, Colin Campbell, Carsten Hansen

We collaborate with other researchers in the UK and overseas:

Fiona Watt, Anil Dhawan, and Giovanna Lombardi, King’s College London
Jan Hengstler and Patricio Godoy, University of Dortmund
Lijian Hui, Shanghai Institutes for Biological Sciences
Ron Hay and Roland Wolf, University of Dundee
Cliona O’Farrelly, Trinity College Dublin
Philip Newsome, University of Birmingham
Jo Mountford, University of Glasgow
Will Shu, Strathclyde University
Stephen Strom, Karolinska Institute
Ludovic Vallier, Cambridge University

Our industry partners include:

Ruchi Sharma, Stemnovate
Kristian Tryggvason, Biolamina
Dominic Williams, Astra Zeneca
Charis Segeritz-Walko – StemCell Technologies

This article was published on 31 Jul, 2020