David Hay
Group Leader and Professor of Tissue Engineering
- Centre for Regenerative Medicine
- Institute for Regeneration and Repair
Contact details
- Tel: 0131 651 9500
- Email: david.hay@ed.ac.uk
Address
- Street
-
Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive - City
- Edinburgh
- Post code
- EH16 4UU
Background
- Group leader of the Pluripotent Stem Cell Hepatocyte Development team
- Expert in cell differentiation and tissue engineering
- Over 15 years’ experience in pluripotent stem cell biology
- Experience of start-up company formation and securing seed funding
- PhD 2000 and BSc (Hons) 1996, University of St Andrews, UK
Open to PhD supervision enquiries?
Yes
Current PhD students supervised
- Matthew Sinton (PhD Student shared with BHF CVR)
- Angus Marks (PhD Student shared with Chemistry)
- Sharmin Alhaque (PhD Student shared with Brunel University)
- Gregor Skeldon (PhD Student shared with Strathclyde University)
Research summary
Liver Tissue Development and Engineering
The liver plays a vital role in human health, including the detoxification of foreign substances. We use stem cells to grow liver tissue in the laboratory. The stem cells we use are called human embryonic stem cells and induced pluripotent stem cells. The attraction of using these cell populations is their indefinite growth in the lab and their ability to form all the cells found in the human body. We have developed reliable methods for building human liver tissue. Encouragingly, it behaves in a similar way to the liver found in the human body. We believe our liver tissue has an important part to play in improving human drug development and repurposing; modelling human disease and in the future may provide an alternative source of human tissue to treat failing human liver function.
Knowledge exchange
-
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure
In:
iScience
DOI: https://doi.org/10.1016/j.isci.2021.102552
Research output: Contribution to Journal › Article (Published) -
Protocol for automated production of human stem cell derived liver spheres
In:
Star Protocols
DOI: https://doi.org/10.1016/j.xpro.2021.100502
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Modelling human hepatic steatosis in pluripotent stem cell-derived hepatocytes
In:
Star Protocols
DOI: https://doi.org/10.1016/j.xpro.2021.100493
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Mathematical modelling of oxygen gradients in stem cell-derived liver tissue
In:
PLoS ONE
Research output: Contribution to Journal › Article (Accepted/In press) -
A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis
In:
iScience, vol. 24
DOI: https://doi.org/10.1016/j.isci.2020.101931
Research output: Contribution to Journal › Article (Published) -
Over-the-counter analgesics during pregnancy: a comprehensive review of global prevalence and offspring safety
In:
Human Reproduction Update
DOI: https://doi.org/10.1093/humupd/dmaa042
Research output: Contribution to Journal › Article (Published) -
Development of a cost effective automated platform to produce human liver spheroids for basic and applied research
In:
Biofabrication, vol. 13
DOI: https://doi.org/10.1088/1758-5090/abbdb2
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells
In:
EXCLI
Research output: Contribution to Journal › Article (Accepted/In press) -
Human PSC-derived hepatocytes express low levels of viral pathogen recognition receptors but are capable of mounting an effective innate immune response
In:
International Journal of Molecular Sciences
Research output: Contribution to Journal › Article (Accepted/In press) -
Introducing Point Mutations into Human Pluripotent Stem Cells using Seamless Genome Editing
In:
Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/61152
Research output: Contribution to Journal › Article (Published) -
Chapter 40 Liver stem cells
Research output: › Chapter (Published) -
The Parliamentary Office of Science and Technology Notes: 3D bioprinting in medicine
In:
The Parliamentary Office of Science and Technology Notes
Research output: Contribution to Journal › Article (Published) -
Hepatic Progenitor Specification from Pluripotent Stem Cells Using a Defined Differentiation System
In:
Journal of Visualized Experiments (JoVE)
Research output: Contribution to Journal › Article (Accepted/In press) -
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
In:
Archives of toxicology
Research output: Contribution to Journal › Article (Published) -
Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells
In:
PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0221762
Research output: Contribution to Journal › Article (Published) -
Serum Free Production of Three-Dimensional Human Hepatospheres from Pluripotent Stem Cells
In:
Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/59965
Research output: Contribution to Journal › Article (Published) -
Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome
In:
Clinical Epigenetics, vol. 11
DOI: https://doi.org/10.1186/s13148-019-0702-5
Research output: Contribution to Journal › Article (Published) -
Multiomics analyses of HNF4a protein domain function during human pluripotent stem cell differentiation
In:
iScience
DOI: https://doi.org/10.1016/j.isci.2019.05.028
Research output: Contribution to Journal › Article (Published) -
Blended electrospinning with human liver extracellular matrix for engineering new hepatic microenvironments
In:
Scientific Reports, vol. 9
DOI: https://doi.org/10.1038/s41598-019-42627-7
Research output: Contribution to Journal › Article (Published) -
The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae
(20 pages)
In:
Current Biology, vol. 29, pp. 242-255.e6
DOI: https://doi.org/10.1016/j.cub.2018.11.066
Research output: Contribution to Journal › Article (Published)
We work collaboratively with a number of groups in Edinburgh:
Stuart Forbes, Ian Wilmut, Bruno Peault, Anura Rambukkana, Jim Ross, Mark Bradley, Anthony Callanan, Mandy Drake, Colin Campbell, Carsten Hansen
We collaborate with other researchers in the UK and overseas:
- Fiona Watt, Anil Dhawan, and Giovanna Lombardi, King’s College London
- Jan Hengstler and Patricio Godoy, University of Dortmund
- Lijian Hui, Shanghai Institutes for Biological Sciences
- Ron Hay and Roland Wolf, University of Dundee
- Cliona O’Farrelly, Trinity College Dublin
- Philip Newsome, University of Birmingham
- Jo Mountford, University of Glasgow
- Will Shu, Strathclyde University
- Stephen Strom, Karolinska Institute
- Ludovic Vallier, Cambridge University
Our industry partners include:
- Ruchi Sharma, Stemnovate
- Kristian Tryggvason, Biolamina
- Dominic Williams, Astra Zeneca
- Charis Segeritz-Walko – StemCell Technologies