Daniela Jaime Garcia

PhD student in translational neuroscience and research assistant in clinical studies of small vessel disease

  • The UK Dementia Research Institute
  • Centre for Clinical Brain Sciences
  • Biomedical Sciences

Contact details



Chancellor's Building
The University of Edinburgh
49 Little France Crescent

Post code
EH16 4SB


Daniela ('Dany') Jaime Garcia is a PhD student in Translational Neuroscience funded by the Wellcome Trust and the University of Edinburgh. She completed her undergraduate degree in psychology and neuroscience at Grinnell College, USA, and subsequently pursued a Masters in Stroke Medicine at the Institute of Neurology, University College London. She has since been a research assistant in clinical studies of small vessel disease with Professor Joanna Wardlaw at the University of Edinburgh, whom she continues to collaborate with for her PhD. During this time, Dany was involved in a variety of clinical research projects, including The Mild Stroke Study 3 and TREAT-SVDs.


BSc (hons) - Psychology and Neuroscience, Grinnell College, Iowa, U.S.A

MSc - Stroke Medicine, Institute of Neurology, University College London, U.K.

Research summary

Dany is investigating the role of pericytes and endothelial cells in the blood-brain-barrier breakdown observed in small vessel disease, Alzheimer's Disease and vascular dementia. Her PhD project aims to include both pre-clinical and clinical components and is supervised by Dr Axel Montagne and Professor Joanna Wardlaw. Her primary research interests centre around cerebrovascular dysfunction and how it contributes to neurodegeneration and include stroke, cognition and ageing. 


Affiliated research centres

Clancy, U., Garcia, D.J., Stringer, M.S., Thrippleton, M.J., Valdés-Hernández, M.C., Wiseman, S., Hamilton, O.K., Chappell, F.M., Brown, R., Blair, G.W. and Hewins, W., 2021. Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3. European stroke journal, 6(1), pp.81-88.

Blair, Gordon W., Michael S. Stringer, Michael J. Thrippleton, Francesca M. Chappell, Kirsten Shuler, Iona Hamilton, Daniela Jaime Garcia et al. "Imaging NeuroVascular, Endothelial and STructural Integrity in prepAration to TrEat Small Vessel Diseases. The INVESTIGATE-SVDs study Protocol. Part of the SVDs@ Target Project." Cerebral Circulation-Cognition and Behavior (2021): 100020.

Jochems, A.C., Blair, G.W., Stringer, M.S., Thrippleton, M.J., Clancy, U., Chappell, F.M., Brown, R., Jaime Garcia, D., Hamilton, O.K., Morgan, A.G. and Marshall, I., 2020. Relationship between venules and perivascular spaces in sporadic small vessel diseases. Stroke, 51(5), pp.1503-1506.

Zhang, J.F., Lim, H.F., Chappell, F.M., Clancy, U., Wiseman, S., Valdés-Hernández, M.C., Garcia, D.J., Bastin, M.E., Doubal, F.N., Hewins, W. and Cox, S.R., 2021. Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease. Neurobiology of Aging.

Manning, C., Stringer, M., Dickie, B., Clancy, U., Valdés Hernandez, M.C., Wiseman, S.J., Garcia, D.J., Sakka, E., Backes, W.H., Ingrisch, M. and Chappell, F., 2021. Sources of systematic error in DCE‐MRI estimation of low‐level blood‐brain barrier leakage. Magnetic Resonance in Medicine.