Bruno Péault
Chair of Vascular Regeneration
- Centre for Cardiovascular Science
- Institute for Regeneration and Repair
Contact details
- Tel: 0131 651 9505
- Email: bruno.peault@ed.ac.uk
Address
- Street
-
Institute for Regeneration and Repair
Queens Medical Research Institute
The University of Edinburgh
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4UU
Open to PhD supervision enquiries?
Yes
Current PhD students supervised
Eleni Besi (PhD Student)
Joan Casamitjana (PhD Student)
Murtadhah Jalal (PhD Student)
Daniel Lerman (PhD student)
Isaac Shaw (PhD Student)
Neelima Thottappillil (PhD Student)
Research summary
Tissue development, regeneration and repair
Our group studies developmental heamatopoiesis and is also interested in the identification, purification, characterization and medical use of multipotent progenitor cells present in all tissues throughout life. The prototype of such ubiquitous progenitor cells is the mesenchymal stem cell, of which we have documented the native perivascular origin.
Working closely with our twin laboratory at the University of California at Los Angeles, we study the biology of perivascular stem cells and their possible role in tissue development, renewal and repair. Importantly, we have already engaged into the medical “translation” of these cells, principally for bone and cartilage regeneration.
-
Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature
In:
Stem Cells Translational Medicine
DOI: https://doi.org/10.1002/sctm.20-0392
Research output: Contribution to Journal › Article (Published) -
Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells
(30 pages)
In:
eLIFE, vol. 9
DOI: https://doi.org/10.7554/eLife.58990
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Platelet-derived growth factor receptor-β (PDGFRβ) lineage tracing highlights perivascular cell to myofibroblast transdifferentiation during post-traumatic osteoarthritis
In:
Journal of Orthopaedic Research
DOI: https://doi.org/10.1002/jor.24648
Research output: Contribution to Journal › Article (E-pub ahead of print) -
PDGFRα marks distinct perivascular populations with different osteogenic potential within adipose tissue
(15 pages)
In:
STEM CELLS, vol. 38, pp. 276-290
DOI: https://doi.org/10.1002/stem.3108
Research output: Contribution to Journal › Article (Published) -
CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials
(15 pages)
In:
STEM CELLS, vol. 38, pp. 261-275
DOI: https://doi.org/10.1002/stem.3112
Research output: Contribution to Journal › Article (Published) -
Non-fibro-adipogenic pericytes from human embryonic stem cells attenuate degeneration of the chronically injured mouse muscle
In:
JCI Insight, vol. 4
DOI: https://doi.org/10.1172/jci.insight.125334
Research output: Contribution to Journal › Article (Published) -
Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization
In:
Journal of Visualized Experiments (JoVE)
DOI: https://doi.org/10.3791/60117
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Aged Mice Demonstrate Greater Muscle Degeneration of Chronically Injured Rotator Cuff
In:
Journal of Orthopaedic Research
DOI: https://doi.org/10.1002/jor.24468
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Perivascular Mesenchymal Progenitors for Bone Regeneration
In:
Journal of Orthopaedic Research, vol. 37
DOI: https://doi.org/10.1002/jor.24284
Research output: Contribution to Journal › Review article (Published) -
International Expert Consensus on a Cell Therapy Communication Tool: DOSES
(8 pages)
In:
Journal of Bone and Joint Surgery, vol. 101, pp. 904-911
DOI: https://doi.org/10.2106/JBJS.18.00915
Research output: Contribution to Journal › Article (Published) -
Skeletogenic capacity of human perivascular stem cells obtained via magnetic activated cell sorting
In:
Tissue Engineering Part A
DOI: https://doi.org/10.1089/ten.TEA.2019.0031
Research output: Contribution to Journal › Article (E-pub ahead of print) -
FOXP1 circular RNA sustains mesenchymal stem cell identity via microRNA inhibition
In:
Nucleic Acids Research
DOI: https://doi.org/10.1093/nar/gkz199
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Ask the experts: current obstacles and future developments in cell culture
(6 pages)
In:
Regenerative medicine, vol. 14, pp. 145-150
DOI: https://doi.org/10.2217/rme-2019-0029
Research output: Contribution to Journal › Article (Published) -
Relative contributions of adipose-resident CD146 pericytes and CD34 adventitial progenitor cells in bone tissue engineering
In:
npj Regenerative Medicine, vol. 4, pp. 1
DOI: https://doi.org/10.1038/s41536-018-0063-2
Research output: Contribution to Journal › Article (Published) -
WISP-1 drives bone formation at the expense of fat formation in human perivascular stem cells
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-018-34143-x
Research output: Contribution to Journal › Article (Published) -
Adipose-derived Human Perivascular Stem Cells May Improve Achilles Tendon Healing in Rats
(10 pages)
In:
Clinical Orthopaedics and Related Research, vol. 476, pp. 2091-2100
DOI: https://doi.org/10.1097/CORR.0000000000000461
Research output: Contribution to Journal › Article (Published) -
Higher pericyte content and secretory activity of micro-fragmented human adipose tissue compared to enzymatically derived stromal vascular fraction
In:
Stem Cells Translational Medicine
DOI: https://doi.org/10.1002/sctm.18-0051
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Changes in coexpression of pericytes and endogenous cardiac progenitor cells from heart development to disease state
In:
European Heart Journal, vol. 39
DOI: https://doi.org/10.1093/eurheartj/ehy565.P1850
Research output: Contribution to Journal › Meeting abstract (Published) -
Neer Award 2018: Neer Award 2018: Platelet-derived growth factor receptor α co-expression typifies a subset of platelet-derived growth factor receptor β–positive progenitor cells that contribute to fatty degeneration and fibrosis of the murine rotator cuff
In:
Journal of shoulder and elbow surgery
DOI: https://doi.org/10.1016/j.jse.2018.02.040
Research output: Contribution to Journal › Article (Published) -
Pericytes in the renal vasculature roles in health and disease
In:
Nature Reviews Nephrology
DOI: https://doi.org/10.1038/s41581-018-0032-4
Research output: Contribution to Journal › Review article (Published)