Andrew McBride
Translational Projects Manager
Address
- Street
-
Queen's Medical Research Institute,
Edinburgh Bioquarter,
47 Little France Crescent, - City
- Edinburgh
- Post code
- EH16 4TJ
Background
A biochemist by training Andrew completed a PhD in Molecular & Cellular Biology at the University of Dundee prior to embarking on Post-doctoral research in drug discovery with Professor Scott Webster at the University of Edinburgh. During this time Andrew gained experience in drug development, working collaboratively with industrial and clinical partners, to take two small molecule enzyme inhibitors to first in human studies. He managed pre-clinical drug development programmes, including pre-clinical safety, to support regulatory submissions.
In 2017 Andrew took up the role of the College of Medicine & Veterinary Medicine Translator in Residence. He used his experience to support researchers in translating their research towards innovative healthcare solutions to unmet clinical and market needs.
In the Autumn of 2021 Andrew took up the role of Entrepreneur in Residence with the Wellcome Trust iTPA team at Edinburgh Innovations. This role will see Andrew work to sustain and increase engagement of early career researchers across the University with translation and commercialisation of research to develop a sustainable pipeline of translational projects and activities. Andrew continues to work 1 day per week for the College as a Translational Project Manager principally managing the College's MRC Confidence in Concept portfolio of projects.
Qualifications
PhD Molecular & Cellular Biology, University of Dundee, 2003-2007
BSc Hons Biochemistry, University of Stirling, 1997-2001
Association for Project Management Project Fundamentals Qualification (2021)
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Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice
In:
Biochemical Pharmacology, vol. 148, pp. 88-99
DOI: https://doi.org/10.1016/j.bcp.2017.12.013
Research output: Contribution to Journal › Article (Published) -
Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction
(17 pages)
In:
European Journal of Medicinal Chemistry, vol. 139, pp. 412-428
DOI: https://doi.org/10.1016/j.ejmech.2017.08.003
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)
In:
British Journal of Pharmacology
DOI: https://doi.org/10.1111/bph.13699
Research output: Contribution to Journal › Article (Published) -
Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
(8 pages)
In:
Nature Medicine, vol. 22, pp. 202-209
DOI: https://doi.org/10.1038/nm.4020
Research output: Contribution to Journal › Article (Published) -
Searching for novel applications of the benzohomoadamantane scaffold in medicinal chemistry: Synthesis of novel 11β-HSD1 inhibitors
In:
Bioorganic and Medicinal Chemistry, vol. 23, pp. 7607-7617
DOI: https://doi.org/10.1016/j.bmc.2015.11.004
Research output: Contribution to Journal › Article (Published) -
Novel 11β-HSD1 inhibitors: C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold
(4 pages)
In:
Bioorganic & Medicinal Chemistry Letters, vol. 25, pp. 4250-3
DOI: https://doi.org/10.1016/j.bmcl.2015.07.097
Research output: Contribution to Journal › Article (Published) -
Cognitive and disease-modifying effects of 11ß-hydroxysteroid dehydrogenase type 1 inhibition in male Tg2576 mice, a model of Alzheimer's disease
In:
Endocrinology
DOI: https://doi.org/10.1210/en.2015-1395
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues
(9 pages)
In:
Analytical Chemistry, vol. 85, pp. 11576-11584
DOI: https://doi.org/10.1021/ac402777k
Research output: Contribution to Journal › Article (Published) -
The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor
(12 pages)
In:
Cell Metabolism, vol. 9, pp. 23-34
DOI: https://doi.org/10.1016/j.cmet.2008.11.008
Research output: Contribution to Journal › Article (Published)