Professor Andrew Goryachev
Contact details
- Tel: 0131 650 7807
- Email: Andrew.Goryachev@ed.ac.uk
Address
- Street
-
Rm. 2.03, Waddington Building, Max Born Crescent
- City
- Post code
- EH9 3BF
Background
Ph.D., University of Toronto
2003 - 2006 Research Scientist and Team Leader, Bioinformatics Institute, Singapore
2006 - 2011 RCUK Academic Fellow, School of Biological Sciences, University of Edinburgh
2010 - 2011 Lecturer in Computational Cell Biology, School of Biological Sciences, University of Edinburgh
2011 - 2016 Reader in Computational Cell Biology, School of Biological Sciences, University of Edinburgh
2016 - Professor of Computational Cell Biology, School of Biological Sciences, University of Edinburgh
Undergraduate teaching
2012 - 2018 BILG08015 Molecules, Genes and Cells
2011 - BICH10009 Membrane Biology
2012 - BILG09001 Molecular Cell Biology.
Postgraduate teaching
2008 - PGBI11051 IPBC Information Processing in Biological Cells
2018 - PGBI11029 Applicable Mathematics
Open to PhD supervision enquiries?
Yes
Research summary
http://goryachev.bio.ed.ac.uk/
Current research interests
My group studies biophysical principles of cellular morphogenesis and intracellular pattern formation. Specifically, we are interested in understanding the mechanisms of symmetry breaking in space and time. In particular, we study cellular developmental programs controlled by small Rho GTPases: Cdc42, Rho and Rac. These include many vital cellular processes, such as the establishment of cell polarity and formation of the cytokinetic furrow.-
Microtubule detyrosination drives symmetry breaking to polarize cells for directed cell migration
(12 pages)
In:
Proceedings of the National Academy of Sciences (PNAS), vol. 120
DOI: https://doi.org/10.1073/pnas.2300322120
Research output: Contribution to Journal › Article (Published) -
Self-organized Rho and F-actin patterning in an artificial cell cortex
DOI: https://doi.org/10.1016/j.bpj.2022.11.1053
Research output: › Poster (Published) -
Cell cycle and developmental control of cortical excitability in Xenopus laevis
(13 pages)
In:
Molecular Biology of the Cell, vol. 33
DOI: https://doi.org/10.1091/mbc.E22-01-0025
Research output: Contribution to Journal › Article (Published) -
A versatile cortical pattern-forming circuit based on Rho, F-actin, Ect2 and RGA-3/4
(39 pages)
In:
Journal of Cell Biology, vol. 221
DOI: https://doi.org/10.1083/jcb.202203017
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling
(28 pages)
In:
Journal of Cell Biology, vol. 221
DOI: https://doi.org/10.1083/jcb.202105107
Research output: Contribution to Journal › Article (Published) -
Rho and F-actin self-organize within an artificial cell cortex
(9 pages)
In:
Current Biology, vol. 31, pp. P5613-5621.E5
DOI: https://doi.org/10.1016/j.cub.2021.10.021
Research output: Contribution to Journal › Article (Published) -
Stochastic contraction of myosin minifilaments drives evolution of microridge protrusion patterns in epithelial cells
In:
Molecular Biology of the Cell
DOI: https://doi.org/10.1091/mbc.E21-05-0258
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Cortical excitability and cell division
In:
Current Biology, vol. 31, pp. PR553-R559
DOI: https://doi.org/10.1016/j.cub.2021.02.053
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Type V myosin focuses the polarisome and shapes the tip of yeast cells
(18 pages)
In:
Journal of Cell Biology, vol. 220
DOI: https://doi.org/10.1083/jcb.202006193 1
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Symmetry breaking as an interdisciplinary concept unifying cell and developmental biology
(4 pages)
In:
Cells, vol. 10
DOI: https://doi.org/10.3390/cells10010086
Research output: Contribution to Journal › Editorial (Published) -
Compete or coexist? Why the same mechanisms of symmetry breaking can yield distinct outcomes
(15 pages)
In:
Cells, vol. 9
DOI: https://doi.org/10.3390/cells9092011
Research output: Contribution to Journal › Article (Published) -
Pattern formation in active model C with anchoring: bands, aster networks, and foams
In:
Soft Matter
DOI: https://doi.org/10.1039/D0SM00927J
Research output: Contribution to Journal › Article (Published) -
Cortical contraction drives the 3D patterning of epithelial cell surfaces
(17 pages)
In:
Journal of Cell Biology, vol. 219
DOI: https://doi.org/10.1083/jcb.201904144
Research output: Contribution to Journal › Article (Published) -
Autoactivation of small GTPases by the GEF–effector positive feedback modules
In:
F1000prime reports
DOI: https://doi.org/10.12688/f1000research.20003.1
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Dry active turbulence in a model for microtubule-motor mixtures
In:
Soft Matter
DOI: https://doi.org/10.1039/C9SM00558G
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Spindle–F-actin interactions in mitotic spindles in an intact vertebrate epithelium
In:
Molecular Biology of the Cell, vol. 30, pp. 1645-1654
DOI: https://doi.org/10.1091/mbc.E19-02-0126
Research output: Contribution to Journal › Article (Published) -
Rho flares repair local tight junction leaks
(20 pages)
In:
Developmental Cell, vol. 48, pp. 445-459
DOI: https://doi.org/10.1016/j.devcel.2019.01.016
Research output: Contribution to Journal › Article (Published) -
Fission yeast NDR/LATS kinase Orb6 regulates exocytosis via phosphorylation of exocyst complex
(21 pages)
In:
Cell Reports, vol. 26, pp. 1654-1667
DOI: https://doi.org/10.1016/j.celrep.2019.01.027
Research output: Contribution to Journal › Article (Published) -
Autoamplification and competition drive symmetry breaking: Initiation of centriole duplication by the PLK4-STIL network
(24 pages)
In:
iScience, vol. 8, pp. 222-235
DOI: https://doi.org/10.1016/j.isci.2018.10.003
Research output: Contribution to Journal › Article (Published) -
Local and global Cdc42 GEFs for fission yeast cell polarity are coordinated by microtubules and the Tea1/Tea4/Pom1 axis
(15 pages)
In:
Journal of Cell Science, vol. 131
DOI: https://doi.org/10.1242/jcs.216580
Research output: Contribution to Journal › Article (Published)