Andrew Baker (BSc (Hons), PhD, FAHA, FESC, FMedSci, FRSE)
Head of Centre for Cardiovascular Science, Gustav Born Chair of Vascular Biology
Address
- Street
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Centre for Cardiovascular Science
The Queen's Medical Research Institute
Edinburgh BioQuarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My lab is interested in the mechanisms that control vascular damage and how to influence repair and regeneration of the vascular system using innovative therapies, including gene-, cell- and RNA-based approaches. Focusing on vascular smooth muscle and endothelial cells, we are defining the non-coding RNA pathways and networks that influence cell function in health and disease and developing interventions to influence beneficially repair and regeneration. We additionally have focus on gene therapy, both in the translational and basic sense. We have developed an innovative gene therapy approach to prevent pathological vascular remodelling associated with coronary artery bypass graft failure and are pursuing this at the clinical interface. We are also generating endothelial cells from human embryonic stem cells for regeneration in ischaemic conditions, and developing an understanding in mechanisms that control endothelial cell commitment and specification.
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Human adenovirus serotype 5 is sensitive to IgM-independent neutralization in vitro and in vivo
In:
Viruses, vol. 11, no. 7
DOI: https://doi.org/10.3390/v11070616
Contribution to journal › Article (Published) -
The Human-Specific and Smooth Muscle Cell-Enriched LncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling.
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.119.314876
Contribution to journal › Article (Published) -
Manganese-enhanced MRI of the myocardium
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2019-315227
Contribution to journal › Review article (Published) -
Single cell transcriptome analyses reveal novel targets modulating cardiac neovascularisation by resident endothelial cells following myocardial infarction
In:
European Heart Journal
DOI: https://doi.org/10.1093/eurheartj/ehz305
Contribution to journal › Article (E-pub ahead of print) -
Transcriptional dynamics of pluripotent stem cell-derived endothelial cell differentiation revealed by single-cell RNA sequencing
In:
European Heart Journal
DOI: https://doi.org/10.1093/eurheartj/ehz351
Contribution to journal › Article (E-pub ahead of print) -
Endothelial Function and Dysfunction in the Cardiovascular System: The Long Non-Coding Road
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvz154
Contribution to journal › Review article (E-pub ahead of print) -
Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues
In:
Nature Communications
DOI: https://doi.org/10.1038/s41467-019-09969-2
Contribution to journal › Article (Published) -
Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129
In:
Non-Coding RNA, vol. 5, no. 2, pp. 31
DOI: https://doi.org/10.3390/ncrna5020031
Contribution to journal › Article (E-pub ahead of print) -
The function of long non-coding RNAs in vascular biology and disease
(8 pages)
In:
Vascular pharmacology, vol. 114, pp. 23-30
DOI: https://doi.org/10.1016/j.vph.2018.06.004
Contribution to journal › Review article (Published) -
Osteocalcin Regulates Arterial Calcification via Altered Wnt Signalling and Glucose Metabolism
In:
Journal of Bone and Mineral Research
DOI: https://doi.org/10.1002/jbmr.3888
Contribution to journal › Article (E-pub ahead of print) -
Importance of long noncoding RNAs in the development and disease of skeletal muscle and cardiovascular lineages
In:
Frontiers in Cell and Developmental Biology
DOI: https://doi.org/10.3389/fcell.2019.00228
Contribution to journal › Article (Published) -
Substantial Dysregulation of miRNA Passenger Strands Underlies the Vascular Response to Injury
In:
Cells, vol. 8, no. 2, pp. 83
DOI: https://doi.org/10.3390/cells8020083
Contribution to journal › Article (Published) -
Endothelial to Mesenchymal Transition in Cardiovascular Disease: Key Mechanisms and Clinical Translation Opportunities
In:
Journal of the American College of Cardiology, vol. 73, no. 2, pp. 190-209
DOI: https://doi.org/10.1016/j.jacc.2018.09.089
Contribution to journal › Article (Published) -
TGFβ, smooth muscle cells and coronary artery disease: a review
In:
Cellular Signalling
DOI: https://doi.org/10.1016/j.cellsig.2018.09.004
Contribution to journal › Article (Published) -
Robust revascularisation in multiple models of limb ischemia using a clinically translatable human stem cell-derived endothelial cell product
In:
Molecular Therapy, vol. 26, no. 7
DOI: https://doi.org/10.1016/j.ymthe.2018.03.017
Contribution to journal › Article (Published) -
Non coding RNAs in vascular disease - from basic science to clinical applications : Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvy121
Contribution to journal › Article (Published) -
Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells
In:
PLoS ONE, vol. 13, no. 4, pp. e0195116
DOI: https://doi.org/10.1371/journal.pone.0195116
Contribution to journal › Article (Published) -
Unravelling atherosclerotic heterogeneity by single cell RNA sequencing
In:
Current Opinion in Lipidology
DOI: https://doi.org/10.1097/MOL.0000000000000559
Contribution to journal › Review article (Published) -
The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease
In:
Vascular pharmacology
DOI: https://doi.org/10.1016/j.vph.2018.11.006
Contribution to journal › Review article (E-pub ahead of print) -
Targeting Non-coding RNA in Vascular Biology and Disease
In:
Frontiers in physiology, vol. 9
DOI: https://doi.org/10.3389/fphys.2018.01655
Contribution to journal › Article (Published)