Andrew Baker (BSc (Hons), PhD, FAHA, FESC, FMedSci, FRSE)
Head of Centre for Cardiovascular Science, Gustav Born Chair of Vascular Biology
Address
- Street
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Centre for Cardiovascular Science
The Queen's Medical Research Institute
Edinburgh BioQuarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My lab is interested in the mechanisms that control vascular damage and how to influence repair and regeneration of the vascular system using innovative therapies, including gene-, cell- and RNA-based approaches. Focusing on vascular smooth muscle and endothelial cells, we are defining the non-coding RNA pathways and networks that influence cell function in health and disease and developing interventions to influence beneficially repair and regeneration. We additionally have focus on gene therapy, both in the translational and basic sense. We have developed an innovative gene therapy approach to prevent pathological vascular remodelling associated with coronary artery bypass graft failure and are pursuing this at the clinical interface. We are also generating endothelial cells from human embryonic stem cells for regeneration in ischaemic conditions, and developing an understanding in mechanisms that control endothelial cell commitment and specification.
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Response to: Are endothelial cell proliferation and mesenchymal transition as distinguishing characteristics of three-week SuHx mice model?
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvad075
Research output: Contribution to Journal › Letter (E-pub ahead of print) -
INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10
In:
Circulation
Research output: Contribution to Journal › Article (Accepted/In press) -
Clonal Expansion in Cardiovascular Pathology
In:
JACC: Basic to Translational Science
Research output: Contribution to Journal › Review article (Accepted/In press) -
The role of the endothelium in SARS-CoV-2 infection and pathogenesis
In:
Current opinion in physiology, vol. 34
DOI: https://doi.org/10.1016/j.cophys.2023.100670
Research output: Contribution to Journal › Article (Published) -
Repeatability and Reproducibility of Cardiac Manganese-Enhanced Magnetic Resonance Imaging
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-023-29591-z
Research output: Contribution to Journal › Article (Published) -
Human and murine fibroblast single cell transcriptomics reveals fibroblast clusters are differentially affected by ageing, and serum cholesterol
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvad016
Research output: Contribution to Journal › Article (Published) -
The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
In:
Basic research in cardiology, vol. 118
DOI: https://doi.org/10.1007/s00395-023-00978-3
Research output: Contribution to Journal › Article (Published) -
Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of replication protein A2
In:
Cell Reports
DOI: https://doi.org/10.1016/j.celrep.2022.111670
Research output: Contribution to Journal › Article (Published) -
Manganese-Enhanced Magnetic Resonance Imaging in Takotsubo Syndrome
In:
Circulation, vol. 146, pp. 1823-1835
DOI: https://doi.org/10.1161/CIRCULATIONAHA.122.060375
Research output: Contribution to Journal › Article (Published) -
Human embryonic stem cell-derived endothelial cell product injection attenuates cardiac remodeling in myocardial infarction
In:
Frontiers in Cardiovascular Medicine
DOI: https://doi.org/10.3389/fcvm.2022.953211
Research output: Contribution to Journal › Article (Published) -
Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvac151
Research output: Contribution to Journal › Article (E-pub ahead of print) -
(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19
In:
Journal of Molecular and Cellular Cardiology Plus
DOI: https://doi.org/10.1016/j.jmccpl.2022.100013
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Sex Difference in Renal Artery Contractility in a Novel CRISPR/Cas9-Generated P2X7 Knockout Rat
(1 page)
In:
The FASEB Journal, vol. 36
DOI: https://doi.org/10.1096/fasebj.2022.36.S1.R5740
Research output: Contribution to Journal › Meeting abstract (Published) -
Protective role of chaperone-mediated autophagy against atherosclerosis
In:
Proceedings of the National Academy of Sciences (PNAS)
DOI: https://doi.org/10.1073/pnas.2121133119
Research output: Contribution to Journal › Article (Published) -
Coronary artery and cardiac disease in patients with type 2 myocardial infarction: A prospective cohort study
In:
Circulation
DOI: https://doi.org/10.1161/CIRCULATIONAHA.121.058542
Research output: Contribution to Journal › Article (Published) -
Cutting a path to effective delivery of genome engineering machinery
In:
Cardiovascular Research, vol. 118, pp. e42-e44
DOI: https://doi.org/10.1093/cvr/cvac034
Research output: Contribution to Journal › Editorial (Published) -
Localization of Long Noncoding RNA in Formalin-Fixed, Paraffin-Embedded Vascular Tissue Using In Situ Hybridization
DOI: https://doi.org/10.1007/978-1-0716-1924-7_41
Research output: › Chapter (Published) -
Mapping the developing human cardiac endothelium at single cell resolution identifies MECOM as a regulator of arteriovenous gene expression
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvac023
Research output: Contribution to Journal › Article (Published) -
Deciphering endothelial heterogeneity in health and disease at single cell resolution: progress and perspectives
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvac018
Research output: Contribution to Journal › Review article (Published) -
Bypass Grafting and Native Coronary Artery Disease Activity
In:
JACC: Cardiovascular Imaging, vol. 15, pp. 875-887
DOI: https://doi.org/10.1016/j.jcmg.2021.11.030
Research output: Contribution to Journal › Article (Published)