Andrew Baker (BSc (Hons), PhD, FAHA, FESC, FMedSci, FRSE)
Head of Centre for Cardiovascular Science, Gustav Born Chair of Vascular Biology
Address
- Street
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Centre for Cardiovascular Science
The Queen's Medical Research Institute
Edinburgh BioQuarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My lab is interested in the mechanisms that control vascular damage and how to influence repair and regeneration of the vascular system using innovative therapies, including gene-, cell- and RNA-based approaches. Focusing on vascular smooth muscle and endothelial cells, we are defining the non-coding RNA pathways and networks that influence cell function in health and disease and developing interventions to influence beneficially repair and regeneration. We additionally have focus on gene therapy, both in the translational and basic sense. We have developed an innovative gene therapy approach to prevent pathological vascular remodelling associated with coronary artery bypass graft failure and are pursuing this at the clinical interface. We are also generating endothelial cells from human embryonic stem cells for regeneration in ischaemic conditions, and developing an understanding in mechanisms that control endothelial cell commitment and specification.
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Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy
In:
Journal of Cardiovascular Magnetic Resonance
DOI: https://doi.org/10.1186/s12968-020-00655-7
Research output: Contribution to Journal › Article (Published) -
T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension.
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.119.315428
Research output: Contribution to Journal › Article (Published) -
Did dendritic cell activation, induced by adenovirus-antibody complexes, play a role in the death of Jesse Gelsinger?
In:
Molecular Therapy
DOI: https://doi.org/10.1016/j.ymthe.2020.02.010
Research output: Contribution to Journal › Comment/debate (Published) -
Manganese-enhanced T1 mapping to quantify myocardial viability: validation with 18F-fluorodeoxyglucose positron emission tomography
In:
Scientific Reports, vol. 10
DOI: https://doi.org/10.1038/s41598-020-58716-x
Research output: Contribution to Journal › Article (Published) -
The LINC00961 transcript and its encoded micropeptide SPAAR regulate endothelial cell function
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvaa008
Research output: Contribution to Journal › Article (Published) -
A Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON)
In:
Arteriosclerosis, Thrombosis, and Vascular Biology
DOI: https://doi.org/10.1161/ATVBAHA.119.313430
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling
In:
Cell communication and signaling, vol. 17
DOI: https://doi.org/10.1186/s12964-019-0449-9
Research output: Contribution to Journal › Article (Published) -
Importance of long noncoding RNAs in the development and disease of skeletal muscle and cardiovascular lineages
In:
Frontiers in Cell and Developmental Biology
DOI: https://doi.org/10.3389/fcell.2019.00228
Research output: Contribution to Journal › Article (Published) -
Osteocalcin Regulates Arterial Calcification via Altered Wnt Signalling and Glucose Metabolism
In:
Journal of Bone and Mineral Research
DOI: https://doi.org/10.1002/jbmr.3888
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The Human-Specific and Smooth Muscle Cell-Enriched LncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling.
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.119.314876
Research output: Contribution to Journal › Article (Published) -
Manganese-enhanced MRI of the myocardium
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2019-315227
Research output: Contribution to Journal › Review article (Published) -
Human adenovirus serotype 5 is sensitive to IgM-independent neutralization in vitro and in vivo
In:
Viruses, vol. 11
DOI: https://doi.org/10.3390/v11070616
Research output: Contribution to Journal › Article (Published) -
Transcriptional dynamics of pluripotent stem cell-derived endothelial cell differentiation revealed by single-cell RNA sequencing
In:
European Heart Journal
DOI: https://doi.org/10.1093/eurheartj/ehz351
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Endothelial Function and Dysfunction in the Cardiovascular System: The Long Non-Coding Road
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvz154
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Single cell transcriptome analyses reveal novel targets modulating cardiac neovascularisation by resident endothelial cells following myocardial infarction
In:
European Heart Journal
DOI: https://doi.org/10.1093/eurheartj/ehz305
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues
In:
Nature Communications
DOI: https://doi.org/10.1038/s41467-019-09969-2
Research output: Contribution to Journal › Article (Published) -
Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129
In:
Non-Coding RNA, vol. 5, pp. 31
DOI: https://doi.org/10.3390/ncrna5020031
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The function of long non-coding RNAs in vascular biology and disease
(8 pages)
In:
Vascular pharmacology, vol. 114, pp. 23-30
DOI: https://doi.org/10.1016/j.vph.2018.06.004
Research output: Contribution to Journal › Review article (Published) -
Substantial Dysregulation of miRNA Passenger Strands Underlies the Vascular Response to Injury
In:
Cells, vol. 8, pp. 83
DOI: https://doi.org/10.3390/cells8020083
Research output: Contribution to Journal › Article (Published) -
Endothelial to Mesenchymal Transition in Cardiovascular Disease: Key Mechanisms and Clinical Translation Opportunities
In:
Journal of the American College of Cardiology, vol. 73, pp. 190-209
DOI: https://doi.org/10.1016/j.jacc.2018.09.089
Research output: Contribution to Journal › Article (Published)