Andrew Baker (BSc (Hons), PhD, FAHA, FESC, FMedSci, FRSE)
Head of Centre for Cardiovascular Science, Gustav Born Chair of Vascular Biology
Address
- Street
-
Centre for Cardiovascular Science
The Queen's Medical Research Institute
Edinburgh BioQuarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My lab is interested in the mechanisms that control vascular damage and how to influence repair and regeneration of the vascular system using innovative therapies, including gene-, cell- and RNA-based approaches. Focusing on vascular smooth muscle and endothelial cells, we are defining the non-coding RNA pathways and networks that influence cell function in health and disease and developing interventions to influence beneficially repair and regeneration. We additionally have focus on gene therapy, both in the translational and basic sense. We have developed an innovative gene therapy approach to prevent pathological vascular remodelling associated with coronary artery bypass graft failure and are pursuing this at the clinical interface. We are also generating endothelial cells from human embryonic stem cells for regeneration in ischaemic conditions, and developing an understanding in mechanisms that control endothelial cell commitment and specification.
-
Mapping the developing human cardiac endothelium at single cell resolution identifies MECOM as a regulator of arteriovenous gene expression
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvac023
Research output: Contribution to Journal › Article (Published) -
Protective role of chaperone-mediated autophagy against atherosclerosis
In:
Proceedings of the National Academy of Sciences
Research output: Contribution to Journal › Article (Accepted/In press) -
Coronary artery and cardiac disease in patients with type 2 myocardial infarction: A prospective cohort study
In:
Circulation
Research output: Contribution to Journal › Article (Accepted/In press) -
Deciphering endothelial heterogeneity in health and disease at single cell resolution: progress and perspectives
In:
Cardiovascular Research
Research output: Contribution to Journal › Review article (Accepted/In press) -
Bypass Grafting and Native Coronary Artery Disease Activity
In:
JACC: Cardiovascular Imaging
Research output: Contribution to Journal › Article (Accepted/In press) -
Nuclear S-nitrosylation impacts tissue regeneration in zebrafish
In:
Nature Communications
DOI: https://doi.org/10.1038/s41467-021-26621-0
Research output: Contribution to Journal › Article (Published) -
MRI and CT coronary angiography in survivors of COVID-19
In:
Heart, pp. heartjnl-2021-319926
DOI: https://doi.org/10.1136/heartjnl-2021-319926
Research output: Contribution to Journal › Article (Published) -
Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvab296
Research output: Contribution to Journal › Article (Published) -
Human AdV-20-42-42, a promising novel adenoviral vector for gene therapy and vaccine product development
In:
Journal of Virology
DOI: https://doi.org/10.1128/JVI.00387-21
Research output: Contribution to Journal › Article (E-pub ahead of print) -
FLI1+ cells transcriptional analysis reveals LMO2-PRDM16 axis in angiogenesis
In:
Proceedings of the National Academy of Sciences
DOI: https://doi.org/10.1073/pnas.2008559118
Research output: Contribution to Journal › Article (Published) -
Histone deacetylase 9 promotes endothelial to mesenchymal transition and an unfavorable atherosclerotic plaque phenotype
In:
Journal of Clinical Investigation
DOI: https://doi.org/10.1172/JCI131178
Research output: Contribution to Journal › Article (Published) -
In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications
In:
Viruses, vol. 13, pp. 1483
DOI: https://doi.org/10.3390/v13081483
Research output: Contribution to Journal › Article (Published) -
Hooked on heart regeneration: the zebrafish guide to recovery
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvab214
Research output: Contribution to Journal › Article (Published) -
Assessment of Stunned and Viable Myocardium Using Manganese-Enhanced Magnetic Resonance Imaging
In:
Open heart
DOI: https://doi.org/10.1136/openhrt-2021-001646
Research output: Contribution to Journal › Article (E-pub ahead of print) -
CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.120.318688
Research output: Contribution to Journal › Article (Published) -
DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING Atherogenic effects of myeloid PHD knockdown
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvab152
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Dissecting the transcriptome in cardiovascular disease
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvab117
Research output: Contribution to Journal › Article (E-pub ahead of print) -
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.120.318124
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Novel transcript discovery expands the repertoire of pathologically-associated, long non-coding RNAs in vascular smooth muscle cells
In:
International Journal of Molecular Sciences
DOI: https://doi.org/10.3390/ijms22031484
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction
In:
International Journal of Molecular Sciences
DOI: https://doi.org/10.3390/ijms22020969
Research output: Contribution to Journal › Article (E-pub ahead of print)