Andrea Caporali
Chancellor's Fellow
Address
- Street
-
Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My lab aims to understand the importance and role of non-coding RNA in the pathophysiology of vascular diseases and during vascular regeneration. Non-coding RNAs have attracted considerable attention in the field of vascular research. What we still don’t understand fully is how their critical regulatory elements target multiple functionally related genes. We use a combination of transcriptomic, functional genomic and imaging approaches to depict the role of newly identified non-coding RNA during angiogenesis and vascular regeneration. By performing loss-of-function studies and pre-clinical imaging we are able to characterize the impact of selected non-coding RNA and their target genes on capillary growth or collateralization in vitro and in vivo. Overall, we look to link the function of newly identified non-coding RNA with their molecular signalling and to describe their wider involvement in vascular regeneration.
Research activities
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Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy
DOI: https://doi.org/10.15252/embr.201948192
Contribution to Journal › Article (E-pub ahead of print) -
Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells
DOI: https://doi.org/10.3390/cancers12040993
Contribution to Journal › Article (Published) -
MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles
DOI: https://doi.org/10.3390/ijms21051733
Contribution to Journal › Article (Published) -
The LINC00961 transcript and its encoded micropeptide SPAAR regulate endothelial cell function
DOI: https://doi.org/10.1093/cvr/cvaa008
Contribution to Journal › Article (Published) -
The Human-Specific and Smooth Muscle Cell-Enriched LncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling.
DOI: https://doi.org/10.1161/CIRCRESAHA.119.314876
Contribution to Journal › Article (Published) -
miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia
DOI: https://doi.org/10.1016/j.omtn.2019.05.002
Contribution to Journal › Article (Published) -
Role of TPBG (Trophoblast Glycoprotein) Antigen in Human Pericyte Migratory and Angiogenic Activity
DOI: https://doi.org/10.1161/ATVBAHA.119.312665
Contribution to Journal › Article (Published) -
MicroRNA-532-5p Regulates Pericyte Function by Targeting the Transcription Regulator BACH1 and Angiopoietin-1
DOI: https://doi.org/10.1016/j.ymthe.2018.08.020
Contribution to Journal › Article (Published) -
Phenotypic miRNA Screen Identifies miR-26b to Promote the Growth and Survival of Endothelial Cells
DOI: https://doi.org/10.1016/j.omtn.2018.08.006
Contribution to Journal › Article (Published) -
Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology
DOI: https://doi.org/10.1093/cvr/cvy184
Contribution to Journal › Article (Published) -
MicroRNA-148b Targets the TGF-β Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing
DOI: https://doi.org/10.1016/j.ymthe.2018.05.002
Contribution to Journal › Article (E-pub ahead of print) -
MicroRNA-based therapeutics in cardiovascular disease
DOI: https://doi.org/10.1042/BST20170037
Contribution to Journal › Review article (Published) -
The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling
DOI: https://doi.org/10.1038/s41598-017-05868-y
Contribution to Journal › Article (E-pub ahead of print) -
Contribution of pericyte paracrine regulation of the endothelium to angiogenesis
DOI: https://doi.org/10.1016/j.pharmthera.2016.10.001
Contribution to Journal › Article (Published) -
The retinoid agonist Tazarotene promotes angiogenesis and wound healing
DOI: https://doi.org/10.1038/mt.2016.153
Contribution to Journal › Article (Published) -
Regulation of angiogenesis through the efficient delivery of microRNAs into endothelial cells using polyamine-coated carbon nanotubes
(32 pages)
DOI: https://doi.org/10.1016/j.nano.2016.02.017
Contribution to Journal › Article (Published) -
Loss of zfp36 expression in colorectal cancer correlates to wnt/ ß-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1
DOI: https://doi.org/10.18632/oncotarget.10828
Contribution to Journal › Article (Published) -
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
DOI: https://doi.org/10.1155/2016/3565127
Contribution to Journal › Literature review (Published) -
Vasopressin regulates extracellular vesicle uptake by kidney collecting duct cells
DOI: https://doi.org/10.1681/ASN.2015050568
Contribution to Journal › Article (Published) -
microRNAs transport in cardiovascular complication of diabetes
(31 pages)
DOI: https://doi.org/10.1016/j.bbalip.2016.01.010
Contribution to Journal › Article (E-pub ahead of print)