Andrea Caporali
Chancellor's Fellow
Address
- Street
-
Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My lab aims to understand the importance and role of non-coding RNA in the pathophysiology of vascular diseases and during vascular regeneration. Non-coding RNAs have attracted considerable attention in the field of vascular research. What we still don’t understand fully is how their critical regulatory elements target multiple functionally related genes. We use a combination of transcriptomic, functional genomic and imaging approaches to depict the role of newly identified non-coding RNA during angiogenesis and vascular regeneration. By performing loss-of-function studies and pre-clinical imaging we are able to characterize the impact of selected non-coding RNA and their target genes on capillary growth or collateralization in vitro and in vivo. Overall, we look to link the function of newly identified non-coding RNA with their molecular signalling and to describe their wider involvement in vascular regeneration.
Research activities
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Eosinophil deficiency promotes aberrant repair and adverse remodelling following acute myocardial infarction
In:
JACC: Basic to Translational Science
DOI: https://doi.org/10.1016/j.jacbts.2020.05.005
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy
In:
EMBO Reports
DOI: https://doi.org/10.15252/embr.201948192
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells
In:
Cancers, vol. 12, pp. 993
DOI: https://doi.org/10.3390/cancers12040993
Research output: Contribution to Journal › Article (Published) -
MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles
In:
International Journal of Molecular Sciences, vol. 21
DOI: https://doi.org/10.3390/ijms21051733
Research output: Contribution to Journal › Article (Published) -
The LINC00961 transcript and its encoded micropeptide SPAAR regulate endothelial cell function
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvaa008
Research output: Contribution to Journal › Article (Published) -
The Human-Specific and Smooth Muscle Cell-Enriched LncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling.
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.119.314876
Research output: Contribution to Journal › Article (Published) -
miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia
In:
Molecular therapy. Nucleic acids, vol. 17, pp. 49-62
DOI: https://doi.org/10.1016/j.omtn.2019.05.002
Research output: Contribution to Journal › Article (Published) -
Role of TPBG (Trophoblast Glycoprotein) Antigen in Human Pericyte Migratory and Angiogenic Activity
In:
Arteriosclerosis, Thrombosis, and Vascular Biology
DOI: https://doi.org/10.1161/ATVBAHA.119.312665
Research output: Contribution to Journal › Article (Published) -
MicroRNA-532-5p Regulates Pericyte Function by Targeting the Transcription Regulator BACH1 and Angiopoietin-1
In:
Molecular Therapy
DOI: https://doi.org/10.1016/j.ymthe.2018.08.020
Research output: Contribution to Journal › Article (Published) -
Phenotypic miRNA Screen Identifies miR-26b to Promote the Growth and Survival of Endothelial Cells
In:
Molecular therapy. Nucleic acids, vol. 13, pp. 29-43
DOI: https://doi.org/10.1016/j.omtn.2018.08.006
Research output: Contribution to Journal › Article (Published) -
Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology
In:
Cardiovascular Research, vol. 114, pp. 1411-1421
DOI: https://doi.org/10.1093/cvr/cvy184
Research output: Contribution to Journal › Article (Published) -
MicroRNA-148b Targets the TGF-β Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing
In:
Molecular Therapy
DOI: https://doi.org/10.1016/j.ymthe.2018.05.002
Research output: Contribution to Journal › Article (E-pub ahead of print) -
MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target
In:
Biochemical Society Transactions
DOI: https://doi.org/10.1042/BST20170037
Research output: Contribution to Journal › Review article (Published) -
The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling
In:
Scientific Reports, vol. 7, pp. 5443
DOI: https://doi.org/10.1038/s41598-017-05868-y
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Contribution of pericyte paracrine regulation of the endothelium to angiogenesis
In:
Pharmacology and Therapeutics
DOI: https://doi.org/10.1016/j.pharmthera.2016.10.001
Research output: Contribution to Journal › Article (Published) -
The retinoid agonist Tazarotene promotes angiogenesis and wound healing
In:
Molecular Therapy
DOI: https://doi.org/10.1038/mt.2016.153
Research output: Contribution to Journal › Article (Published) -
Regulation of angiogenesis through the efficient delivery of microRNAs into endothelial cells using polyamine-coated carbon nanotubes
(32 pages)
In:
Nanomedicine: Nanotechnology, Biology and Medicine, vol. 12, pp. 1511–1522
DOI: https://doi.org/10.1016/j.nano.2016.02.017
Research output: Contribution to Journal › Article (Published) -
Loss of zfp36 expression in colorectal cancer correlates to wnt/ ß-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1
In:
Oncotarget
DOI: https://doi.org/10.18632/oncotarget.10828
Research output: Contribution to Journal › Article (Published) -
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
In:
Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 3565127
DOI: https://doi.org/10.1155/2016/3565127
Research output: Contribution to Journal › Literature review (Published) -
Vasopressin regulates extracellular vesicle uptake by kidney collecting duct cells
In:
Journal of the American Society of Nephrology, vol. 27, pp. 3345-3355
DOI: https://doi.org/10.1681/ASN.2015050568
Research output: Contribution to Journal › Article (Published)