Andrea Caporali
Senior Lecturer
Address
- Street
-
Queen's Medical Research Institute
47 Little France Crescent
Edinburgh BioQuarter - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My lab aims to understand the importance and role of non-coding RNA in the pathophysiology of vascular diseases and during vascular regeneration. Non-coding RNAs have attracted considerable attention in the field of vascular research. What we still don’t understand fully is how their critical regulatory elements target multiple functionally related genes. We use a combination of transcriptomic, functional genomic and imaging approaches to depict the role of newly identified non-coding RNA during angiogenesis and vascular regeneration. By performing loss-of-function studies and pre-clinical imaging we are able to characterize the impact of selected non-coding RNA and their target genes on capillary growth or collateralization in vitro and in vivo. Overall, we look to link the function of newly identified non-coding RNA with their molecular signalling and to describe their wider involvement in vascular regeneration.
Research activities
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Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart
In:
Journal of Clinical Investigation, vol. 132
DOI: https://doi.org/10.1172/JCI152308
Research output: Contribution to Journal › Article (Published) -
Long Non-Coding RNA Regulation of Epigenetics in Vascular Cells
In:
Non-Coding RNA, vol. 7, pp. 62
DOI: https://doi.org/10.3390/ncrna7040062
Research output: Contribution to Journal › Review article (Published) -
Protective Role of Mytilus edulis Hydrolysate in Lipopolysaccharide-Galactosamine Acute Liver Injury
In:
Frontiers in pharmacology, vol. 12
DOI: https://doi.org/10.3389/fphar.2021.667572
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Autophagy at the interface of endothelial cell homeostasis and vascular disease
In:
Febs Journal
DOI: https://doi.org/10.1111/febs.15873
Research output: Contribution to Journal › Article (E-pub ahead of print) -
How a new drug is born
In:
European Heart Journal
DOI: https://doi.org/10.1093/eurheartj/ehab076
Research output: Contribution to Journal › Article (E-pub ahead of print) -
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.120.318124
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Manipulating Pericyte Function with MicroRNAs
(15 pages)
DOI: https://doi.org/10.1007/978-1-0716-1056-5_10
Research output: › Chapter (peer-reviewed) (Published) -
Dendrimer-coated carbon nanotubes deliver dsRNA and increase the efficacy of gene knockdown in the red flour beetle Tribolium castaneum
In:
Scientific Reports, vol. 10, pp. 12422
DOI: https://doi.org/10.1038/s41598-020-69068-x
Research output: Contribution to Journal › Article (Published) -
Mir-96 and miR-183 differentially regulate neonatal and adult post-infarct neovascularisation
In:
JCI Insight, vol. 5
DOI: https://doi.org/10.1172/jci.insight.134888
Research output: Contribution to Journal › Article (Published) -
Eosinophil deficiency promotes aberrant repair and adverse remodelling following acute myocardial infarction
In:
JACC: Basic to Translational Science
DOI: https://doi.org/10.1016/j.jacbts.2020.05.005
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy
In:
EMBO Reports
DOI: https://doi.org/10.15252/embr.201948192
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells
In:
Cancers, vol. 12, pp. 993
DOI: https://doi.org/10.3390/cancers12040993
Research output: Contribution to Journal › Article (Published) -
MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles
In:
International Journal of Molecular Sciences, vol. 21
DOI: https://doi.org/10.3390/ijms21051733
Research output: Contribution to Journal › Article (Published) -
The LINC00961 transcript and its encoded micropeptide SPAAR regulate endothelial cell function
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvaa008
Research output: Contribution to Journal › Article (Published) -
The Human-Specific and Smooth Muscle Cell-Enriched LncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling.
In:
Circulation Research, vol. 125, pp. 535–551
DOI: https://doi.org/10.1161/CIRCRESAHA.119.314876
Research output: Contribution to Journal › Article (Published) -
miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia
In:
Molecular Therapy - Nucleic Acids, vol. 17, pp. 49-62
DOI: https://doi.org/10.1016/j.omtn.2019.05.002
Research output: Contribution to Journal › Article (Published) -
Role of TPBG (Trophoblast Glycoprotein) Antigen in Human Pericyte Migratory and Angiogenic Activity
In:
Arteriosclerosis, Thrombosis, and Vascular Biology
DOI: https://doi.org/10.1161/ATVBAHA.119.312665
Research output: Contribution to Journal › Article (Published) -
MicroRNA-532-5p Regulates Pericyte Function by Targeting the Transcription Regulator BACH1 and Angiopoietin-1
In:
Molecular Therapy
DOI: https://doi.org/10.1016/j.ymthe.2018.08.020
Research output: Contribution to Journal › Article (Published) -
Phenotypic miRNA Screen Identifies miR-26b to Promote the Growth and Survival of Endothelial Cells
In:
Molecular Therapy - Nucleic Acids, vol. 13, pp. 29-43
DOI: https://doi.org/10.1016/j.omtn.2018.08.006
Research output: Contribution to Journal › Article (Published) -
MicroRNA-148b Targets the TGF-β Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing
In:
Molecular Therapy, vol. 26, pp. 1996-2007
DOI: https://doi.org/10.1016/j.ymthe.2018.05.002
Research output: Contribution to Journal › Article (Published)