Bryan Conway
Senior Clinical Lecturer
Address
- Street
-
Centre for Cardiovascular Science,
The Queen's Medical Research Institute,
Edinburgh BioQuarter,
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
Diabetic kidney disease is the single most common cause of end-stage renal disease in the Western world, accounting for 20% of all incident cases of dialysis in the UK and up to 50% in the US. I am investigating the pathogenesis of diabetic nephropathy, combining novel rodent models with unbiased gene expression analysis. Good blood sugar and blood pressure control can result in regression of nephropathy in patients with diabetes and I am particularly interested in dissecting the mechanisms by which this may occur. This work is in collaboration with Prof John Mullins, Dr Matt Bailey and Dr Laura Denby from the Centre for Cardiovascular Science and Dr Jeremy Hughes and Prof Neil Henderson from the CIR. I am also collaborating with the Edinburgh Type 2 Diabetes Study Investigators to examine the utility of urinary biomarkers to predict renal outcome in patients with type 2 diabetes. The recent increase in the incidence of diabetic nephropathy is largely driven by the epidemic of obesity and type 2 diabetes. Therefore I am collaborating with Prof Nik Morton from the Centre for Cardiovascular Science to investigate the pathogenesis of obesity and type 2 diabetes.
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Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis
In:
JCI Insight, vol. 7
DOI: https://doi.org/10.1172/jci.insight.154124
Research output: Contribution to Journal › Article (Published) -
Frequency and phenotype associations of rare variants in 5 monogenic cerebral small vessel disease genes in 200,000 UK Biobank participants
In:
Neurology Genetics, vol. 8, pp. e200015
DOI: https://doi.org/10.1212/NXG.0000000000200015
Research output: Contribution to Journal › Article (Published) -
Sonoporation of human renal proximal tubular epithelial cells in vitro to enhance the liberation of intracellular miRNA biomarkers.
In:
Ultrasound in Medicine and Biology (UMB)
DOI: https://doi.org/10.1016/j.ultrasmedbio.2022.01.019
Research output: Contribution to Journal › Article (E-pub ahead of print) -
scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain
In:
Cellular Physiology and Biochemistry
DOI: https://doi.org/10.33594/000000366
Research output: Contribution to Journal › Article (E-pub ahead of print) -
A National Registry Study of Patient and Renal Survival in Adult Nephrotic Syndrome
In:
Kidney International Reports, vol. 6, pp. 449-459
DOI: https://doi.org/10.1016/j.ekir.2020.10.033
Research output: Contribution to Journal › Article (Published) -
Identifying cell enriched miRNAs in kidney injury and repair
In:
JCI Insight, vol. 5
DOI: https://doi.org/10.1172/jci.insight.140399
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease
In:
Journal of the American Society of Nephrology, vol. 31, pp. 2833–2854
DOI: https://doi.org/10.1681/ASN.2020060806
Research output: Contribution to Journal › Article (Published) -
Endothelin-1 mediates the systemic and renal hemodynamic effects of GPR81 activation
In:
Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.119.14308
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction
In:
Frontiers in physiology, vol. 10
DOI: https://doi.org/10.3389/fphys.2019.01365
Research output: Contribution to Journal › Article (Published) -
The Efficacy of Puromycin and Adriamycin for Induction of Glomerular Failure in Larval Zebrafish Validated by an Assay of Glomerular Permeability Dynamics
In:
Zebrafish
DOI: https://doi.org/10.1089/zeb.2017.1527
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Cardiovascular Disease Biomarkers Are Associated With Declining Renal Function in Type 2 Diabetes
In:
Diabetologia
DOI: https://doi.org/10.1007/s00125-017-4297-0
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Vasoactive effects of P2X7 receptors in the aorta of control and hypertensive mice
Research output: › Abstract (Published) -
Renal disease pathophysiology and treatment: contributions from the rat
(15 pages)
In:
Disease Models and Mechanisms, vol. 9, pp. 1419-1433
DOI: https://doi.org/10.1242/dmm.027276
Research output: Contribution to Journal › Literature review (E-pub ahead of print) -
Wnt6 - another player in the Yin and Yang of renal Wnt signalling
In:
American Journal of Physiology - Renal Physiology, pp. ajprenal.00296.2016
DOI: https://doi.org/10.1152/ajprenal.00296.2016
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes
In:
Kidney International, vol. 89, pp. 1125–1135
DOI: https://doi.org/10.1016/j.kint.2016.01.015
Research output: Contribution to Journal › Article (Published) -
An update on the use of animal models in diabetic nephropathy research
In:
Current Diabetes Reviews
DOI: https://doi.org/10.1007/s11892-015-0706-2
Research output: Contribution to Journal › Article (Published) -
Mineralocorticoid Excess or Glucocorticoid Insufficiency: Renal and Metabolic Phenotypes in a Rat Hsd11b2 Knockout Model
In:
Hypertension, vol. 66
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.115.05262
Research output: Contribution to Journal › Article (Published) -
Vascular and inflammatory actions of P2X receptors in renal injury
In:
Autonomic Neuroscience: Basic and Clinical, vol. 191, pp. 135–140
DOI: https://doi.org/10.1016/j.autneu.2015.05.001
Research output: Contribution to Journal › Article (Published) -
End-stage renal disease and survival in people with diabetes: a national database linkage study
(8 pages)
In:
QJM: An International Journal of Medicine, vol. 108, pp. 127-134
DOI: https://doi.org/10.1093/qjmed/hcu170
Research output: Contribution to Journal › Article (Published) -
Tight blood glycaemic and blood pressure control in experimental diabetic nephropathy reduces extracellular matrix production without regression of fibrosis
In:
Nephrology, pp. 802-813
DOI: https://doi.org/10.1111/nep.12335
Research output: Contribution to Journal › Article (Published)