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Research in a Nutshell
Autophagy is an evolutionarily-conserved mechanism by which cells remove old proteins and organelles by transporting them to the lysosome (in effect, a cellular garbage disposal facility). The autophagy pathway also acts as a hub for control of cell fate by degrading specific signalling and structural proteins of the cell. These actions are important for the progression of a number of cancers. We use protein-protein interaction screens, imaging techniques and transgenic models to unpick the molecular events set in train by autophagy within pre-cancerous and cancerous cells. Thusly we gain understanding of new cellular processes that could be targeted for future cancer therapies.
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People | |
| Simon Wilkinson | Principal Investigator, CRUK Senior Fellow |
| Natalia Jimenez-Moreno | Postdoc |
| Marisa Di Monaco | Postdoc |
| Mihaela Bozic | Student |
| Tian En Lim | Student |
| Carla Salomo-Coll | Student |
| Jocelyn Bisson | Student |
| Katie Winnington-Ingram | Research Technician |