Autophagy in Tissue Homeostasis and Cancer
Autophagy is an evolutionarily-conserved mechanism by which cells remove old proteins and organelles by transporting them to the lysosome (in effect, a cellular garbage disposal facility). The autophagy pathway also acts as a hub for control of cell fate by degrading specific signalling and structural proteins of the cell. These actions are important for the progression of a number of cancers. We use protein-protein interaction screens, imaging techniques and transgenic models to unpick the molecular events set in train by autophagy within pre-cancerous and cancerous cells. Thusly we gain understanding of new cellular processes that could be targeted for future cancer therapies.
Principal Investigator, CRUK Career
|Alain Kemp||Research Technician|
|Margaret Harley MacDonald||Postdoc|
Autophagy, Cell death, Inflammation, Exocrine system, Ageing, Cancer
Protein-protein interaction, CRISPR/Cas9-genome editing, Super-resolution microscopy, Electron microscopy, Transgenic mouse models