Professor Colin Semple
Group Leader, Head of IGC Bioinformatics Analysis Core
- MRC Human Genetics Unit
- Institute of Genetics and Cancer
Contact details
- Tel: +44 (0)131 651 8614
- Fax: +44 (0) 131 651 8800
- Email: colin.semple@ed.ac.uk
Address
- Street
-
Institute of Genetics and Cancer,
Western General Hospital,
Crewe Road, - City
- Edinburgh
- Post code
- EH4 2XU
Background
Since 2001 I have led the Bioinformatics Analysis Core at the Institute of Genetics and Cancer (IGC), supporting approximately 500 scientists. We provide computational collaborative expertise to IGC experimental research groups, and also large research consortia such as the Scottish Genomes Partnership. I am also a member of the Edinburgh-St Andrews MRC Molecular Pathology Hub, the EpiGeneSys EU-wide network of excellence in epigenetics and systems biology, various MRC review panels and journal editorial boards. My PhD was in population genetics at the University of Edinburgh (1994), followed by postdoctoral stints at the University of Michigan and Trinity College Dublin exploring the first genome sequences derived from yeast and worms. In 1998 I joined the MRC Human Genetics Unit, studying the initial human genome sequence to understand human disease predisposition. These interests have continued to the present, with a current focus on regulatory variation in cancers and developmental disorders.
Qualifications
Doctor of Philosophy (PhD), Population Genetics, University of Edinburgh
Bachelor of Science, Bioogical Sciences, Edinburgh Napier University
Open to PhD supervision enquiries?
Yes
-
Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types
(19 pages)
In:
PLoS Genetics, vol. 12
DOI: https://doi.org/10.1371/journal.pgen.1006207
Research output: Contribution to Journal › Article (Published) -
Modeling double strand break susceptibility to interrogate structural variation in cancer
In:
Genome Biology, vol. 20
DOI: https://doi.org/10.1186/s13059-019-1635-1
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Pan-cancer analysis of whole genomes
(12 pages)
In:
Nature, vol. 578, pp. 82-93
DOI: https://doi.org/10.1038/s41586-020-1969-6
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Pervasive lesion segregation shapes cancer genome evolution
(6 pages)
In:
Nature, vol. 583, pp. 265–270
DOI: https://doi.org/10.1038/s41586-020-2435-1
Research output: Contribution to Journal › Article (Published) -
Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome
In:
Genome Research
DOI: https://doi.org/10.1101/gr.275407.121
Research output: Contribution to Journal › Article (Published)