Edinburgh Clinical Trials

Cardiac CARE

A multicentre prospective randomised open-label blinded end-point controlled trial of high-sensitivity cardiac troponin I-guided combination angiotensin receptor blockade and beta blocker therapy to prevent cardiac toxicity in breast cancer and lymphoma patients receiving anthracycline adjuvant therapy.

This study tests whether tablet medications called angiotensin receptor blockers (ARB) and B-blockers can prevent heart muscle injury related to chemotherapy in breast cancer patients. We will also show whether a convenient blood test (troponin I) can detect those patients at risk of heart failure.


Cardiac Care

Chief Investigator: Dr Peter Henriksen

Number and location of participating sites (by region/ country): UK

EudraCT number: 2017-000896-99

ISRCTN number: ISRCTN24439460


Funder: NIHR EME and BHF

Start and End date

Of grant award: 01 April 2017 to 30 October 2022

Of recruitment: 4 October 2017 to 30 June 2021


Current Status: Completed


Study Protocol: 


Study Results:  Abstract


Study Results: Plain English Summary


Study Results: Scientific Summary


Trial Website: The Cardiac CARE Trial

Email: Cardiac-CARE@ed.ac.uk


UK GDPR Privacy Statement: If you have participated in this study and would like to read how it complies with UK GDPR, please read this document.


Co-sponsor Representative: http://accord.scot/

Dr Fiach O'Mahony, ACCORD, University of Edinburgh & NHS Lothian, The Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ; 0131 2429418; fiach.o'mahony@ed.ac.uk


Chief Investigator

Dr Peter Henriksen, Edinburgh Heart Centre, Western General Hospital, Crewe Road South, Edinburgh’ EH4 2XU; Tel: 0131 242 3843; Email: phenrik1@exseed.ed.ac.uk


Trial Manager

Dr Morag MacLean, Edinburgh Clinical Trials Unit, University of Edinburgh, Nine Edinburgh Bioquarter, 9 Little France Road, EDINBURGH, EH16 4UX ; tel 0131 651 9914; morag.maclean@ed.ac.uk


ECTU involvement: Trial management / Statistics / Data base and randomisation / Health Economics.