This study tests whether tablet medications called angiotensin receptor blockers (ARB) and B-blockers can prevent heart muscle injury related to chemotherapy in breast cancer patients. We will also show whether a convenient blood test (troponin I) can detect those patients at risk of heart failure.
Chief Investigator: Dr Peter Henriksen
Number and location of participating sites (by region/ country): UK
EudraCT number: 2017-000896-99
ISRCTN number: ISRCTN24439460
Funder: NIHR EME and BHF
Start and End date
Of grant award: 01 April 2017 to 30 October 2022
Of recruitment: 4 October 2017 to 30 June 2021
Current Status: Completed
Study Protocol:
Study Results: Abstract
Study Results: Plain English Summary
Study Results: Scientific Summary
Trial Website: The Cardiac CARE Trial
Email: Cardiac-CARE@ed.ac.uk
UK GDPR Privacy Statement: If you have participated in this study and would like to read how it complies with UK GDPR, please read this document.
Co-sponsor Representative: http://accord.scot/
Dr Fiach O'Mahony, ACCORD, University of Edinburgh & NHS Lothian, The Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ; 0131 2429418
Chief Investigator
Dr Peter Henriksen, Edinburgh Heart Centre, Western General Hospital, Crewe Road South, Edinburgh’ EH4 2XU; Tel: 0131 242 3843
Trial Manager: Edinburgh Clinical Trials Unit, University of Edinburgh, Nine Edinburgh Bioquarter, 9 Little France Road, EDINBURGH, EH16 4UX ; tel 0131 651 9914
ECTU involvement: Trial management / Statistics / Data base and randomisation / Health Economics.
(UKCRC)