Archived list of the 2012 seminars & events at the Centre for Discovery Brain Sciences. January SNARE-mediated exocytosis and new botulinum molecules Friday 13 January 2012, 12.30pm Dr Bazbek Davletov (MRC Laboratory of Molecular Medicine, Cambridge) Anatomy and physiology of oxytocin and vasopressin brain circuits, evaluated by the use of recombinant viruses Friday 20 January 2012, 12.30pm Dr Valery Grinevich (Max Planck Institute for Medical Research, Germany) Remote control of developmental gene expression Friday 27 January 2012, 12.30pm Prof Bob Hill (MRC Human Genetics Unit) February Transcriptional control of neural stem cell fates in the embryonic and adult mouse brain Friday 3 February 2012, 12.30pm Dr Francois Guillemot (National Institute for National Research, London) Neocortical information processing Tuesday 7 February 2012, 12.30pm Organ patterning: the power of self-loathing Friday 10 February 2012, 12.30pm Prof Jamie Davies (Centre for Integrative Physiology) Pituitary Plasticity Tuesday 14 February 2012, 12.30pm Dr Paul le Tissier (MRC National Institute for Medical Research, London) Seeing in depth: axon guidance mechanisms controlling the development of the binocular visual pathways Friday 17 February 2012, 12.30pm Dr Lynda Erskine (University of Aberdeen) New kidneys for old; a challenge for surgery and tissue engineering Wednesday 22 February 2012, 12.30pm Prof Jamie Davies (and Mr John Casey) **This talk is part of the 'Let's talk about Healthy Futures' series at QMRI, Little France Crescent.** Specification, maintenance and elimination of neuromesodermal axial progenitors Friday 24 February 2012, 12.20pm Dr Val Wilson (MRC Centre for Regenerative Medicine) March GABAergic interneurons in circuit function and behaviour Friday 2 March 2012, 12.30pm Prof Peer Wulff (University of Aberdeen) How spontaneous activity wires the developing brain prior to experience Monday 5 March 2012, 12.30pm Dr Christian Lohmann (Netherlands Institute for Neuroscience) Old hormones - new insights Friday 9 March 2012, 12.30pm Prof Mike Ludwig (Centre for Integrative Physiology) What are you looking at? Changing a visual cortex neuron's view Friday 16 March 2012, 12.30pm Dr Jason Kerr (Max Planck Institute for Biological Cybernetics, Germany) Receptor signalling pathways regulating melanocyte development and function Friday 23 March 2012, 12.30pm Dr Ian Jackson (MRC Human Genetics Unit) Making blood from stem cells: from molecular mechanisms to clinical applications Friday 23 March 2012, 12.30pm Dr Lesley Forrester (MRC Centre for Inflammation Research) Getting Acquainted: Selective Habituation through Perceptual Learning Wednesday 28 March 2012, 11.30am Dr Sam Cooke (Massachusetts Institute of Technology) Extrasynaptic GABA-A receptors as a therapeutic drug target Friday 30 March 2012, 11.30am Dr Stephen Brickley (Imperial College, London) Spatially Standardized Cell Biology Friday 30 March 2012, 11.30am April Synaptic plasticity in hippocampal inhibitory interneurons Friday 13 April 2012, 11.30am Dr Karri Lamsa (University of Oxford) Exploring the mouse visual cortex in vivo with two photon calcium imaging Thursday 19 April 2012, 11.30am Dr. Nathalie Rochefort (Institute of Neuroscience, Germany) CRACing a Role for Cholesterol in the Salvador Tumour Suppressor Pathway Friday 20 April 2012, 11.30am Dr Mark Ditzel (Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research Centre) A twist in the tail: ligand-induced selective signalling at the 5-HT2A receptor Friday 20 April 2012, 11.30am Dr Rory Mitchell (Centre for Integrative Physiology) Central regulation of the hypothalamic-pituitary-thyroid axis in non-thyroidal illness syndroma Friday 27 April 2012, 11.30am Dr Csaba Fekete (Institute of Experimental Medicine of the Hungarian Academy of Sciences) May Living in the balance with WT1 and beta-catenin Friday 4 May 2012, 11.30am Dr Peter Hohenstein (MRC Human Genetics Unit) NMDAR subtypes: pharmacology and function Friday 4 May 2012, 11.30am Prof David Wyllie (Centre for Integrative Physiology) Antipsychotic drugs in synaptic vesicle recycling Friday 11 May 2012, 11.30am Dr. Teja Groemer (University of Erlangen) Local Translation in Neurons Friday 18 May 2012, 11.30am Prof Erin Schuman (Max Planck Institute for Brain Research, Germany) Joint seminar with Informatics Forum (12.30) Forming sparse olfactory memories Friday 18 May 2012, 11.30am Prof Gilles Laurent (Max Planck Institute for Brain Research, Germany) Joint seminar with Informatics Forum (4pm) June Impaired 5-HT2CR mediated anorexia in a mouse model of Prader-Willi Syndrome Thursday 28 June 2012, 11.30am Dr Alastair Garfield (University of Cambridge) July The Physiological Society Physiology 2012 features prize lectures, symposia, as well as Oral and Poster Communications. Edinburgh, 2 - 5 July 2012 This is an excellent opportunity for all CIP PhD students, postdocs and academic staff to showcase the outstanding science in CIP. Physiology 2012 Synaptic transmission and plasticity in the developed and developing cortex Friday 6 July 2012, 11.30am Dr Neil Hardingham (Cardiff University) Anatomical Society meeting An international symposium of basic and applied biology: Motor Neurones and Diseases of Motor Neurone. The Royal College of Surgeons, Edinburgh, 10 - 12 July 2012 Anatomical Society meeting 2012 Mechanisms Governing Sensory Processing in the Superior Colliculus Friday 20 July 2012, 11.30am Dr Gabe Murphy (HHMI: Janelia Farm Research Campus) September Translation control in synaptic function and neurodevelopmental disorders Thursday 6 September 2012, 11.30am Dr Emily Osterweil, Picower Institute for Learning and Memory, MIT, USA Friday 7th September “Signalling danger”: How C. elegans senses and responds to oxygen Friday 7 September 2012, 11.30am Emanuel Busch, MRC Laboratory of Molecular Biology, Cambridge Abstract: To avoid dangerous environments or maintain homeostasis, animals must constantly monitor key sensory modalities such as temperature or oxygen. Tonic sensory receptors can perceive such constant information but are not well understood. How are responses to sustained sensory signals generated, and how do they reconfigure neural circuits to change animal behaviour? The nematode Caenorhabditis elegans controls exposure to ambient oxygen by migrating away from excessive (21%) or low (<5%) levels. Using Ca2+ imaging, behavioural assays and optogenetic stimulation, I studied the mechanisms underlying avoidance of high [O2]. I found that a set of four sensory neurons continuously responds to ambient oxygen. Tonic signalling in these neurons is sustained by a ‘calcium relay’ that consists of cGMP-gated channels, voltage-gated calcium channels, as well as the ryanodine and IP3 receptor channels, releasing calcium from intracellular stores. Tonic activity of the O2-sensing neurons is necessary and sufficient to set behavioural state according to external [O2] for many minutes and even hours. Sustained signalling in these neurons evokes continuous neuropeptide release, which helps to increase locomotory speed at high [O2]. Tonic signalling propagates to downstream neural circuits, including to a hub interneuron required to mediate oxygen responses. Intriguingly, the same neurons can also induce short transient escape movements, away from high O2. This depends on transformation of the tonic signal to a phasic one in a separate set of downstream command interneurons. My results bring to light how tonic homeostatic signals are generated and how they can induce both long-lasting and transient changes in neural circuits and behaviour. Balancing the brain: formation and plasticity of inhibitory synapses Wednesday 26 September 2012, 11.30am Dr Corette Wierenga, Utrecht University, The Netherlands Postsynaptic Ca2+ regulates synaptic strength at the Drosophila larval NMJ Friday 28 September 2012, 11.30am Greg Lnenicka, State University of New York (SUNY) at Albany, New York, USA October Sensing change - the aetiology and repair of ciliopathies Friday 5 October 2012, 11.30am Philip Beales (University College London, London) Intrinsic biophysical diversity and connectivity of mammalian neuronal circuits Friday 19 October 2012, 11.30am Troy Margrie (NIMR, London) Understanding and manipulating remyelination in models of multiple sclerosis Friday 26 October 2012, 11.30am Anna Williams (Centre for Regenerative Medicine, University of Edinburgh) Abstract: The aim of my research group is to 1) understand why remyelination fails in Multiple Sclerosis and 2) improve the efficiency of remyelination in Multiple Sclerosis. We are particularly interested in the molecules controlling the migration and maturation of oligodendrocyte precursor cells in the adult central nervous system as the migration of these repairing cells into MS lesions and their maturation to form myelin sheaths are critical in remyelination. In particular, we are investigating the guidance molecules Semaphorin 3A and 3F and their receptors which are repulsive (semaphorin 3A) or attractive (semaphorin 3F) signals for oligodendrocyte precursor cells. To address these questions, we have developed and use in vitro, ex vivo and in vivo systems in both rodent and zebrafish. November Sharpey-Schafer Lecture 2nd November 2012 at 12.30pm in the Lecture Theatre, Hugh Robson Building. This year's lecture will be delivered by Dr Patrice Mollard, Department of Endocrinology, Institute of Functional Genomics, Montpellier, France. Sharpey-Schafer lecture Physiological Development of Thalamocortical Input to Barrel Cortex Friday 2 November 2012, 12.30pm Michael Daw (CIP, University of Edinburgh) Abstract: The development of normal adult connectivity and function in many areas of the brain is dependent on experience in early life. In rodents, sensory information from the whiskers is encoded in a region called the barrel cortex, so-named because of barrel-like structures of cells. A one-to-one whisker-to-barrel map is shaped by early sensory experience. We use the barrel cortex as a model to understand the cellular and synaptic processes which underlie experience-dependent cortical development. Research links with China Professor Mark Evans reports on recent events which were organised jointly with Zhejiang University in China. The events resulted from the signing of a Memorandum of Understanding between the Centre for Integrative Physiology and Zhejiang University. Research links with China Inaugural lecture: Professor Mayank Dutia 12th November 2012 from 5.15-6.15pm in Lecture Theatre A, The Chancellor’s Building, 49 Little France Crescent, Edinburgh. Professor Mayank Dutia, Personal Chair of Systems Neurophysiology, will deliver his inaugural lecture with the title 'On balance: and the lack of it'. Human pluripotent stem cell models of synucleinopathies Friday 16 November 2012, 12.30pm Tilo Kunath (Euan MacDonald Centre, University of Edinburgh) Dr Kunath will talk about the use of induced pluripotent stem (iPS) cells and human embryonic stem (hES) cells to model neurological diseases, such as Parkinson's. Competence and neuronal subtype specification in the thalamus Friday 30 November 2012, 12.30pm Clemens Kiecker (MRC Centre for Developmental Neurobiology, King’s College London) Abstract: A small number of intercellular signalling factors regulate multiple different processes in the developing vertebrate brain. The effects mediated by these signals depend not only on the nature of the signal itself, but also on the responsiveness of the receiving cells ('competence'). The molecular nature of the signals that regulate brain development is relatively well understood, but comparably little is known about factors that convey cellular competence. We have identified two factors that regulate the differential responsiveness of cells in the developing thalamus to the signalling factor Sonic hedgehog. December Optical imaging in the CMVM - Where we are and what the future holds Friday 7 December 2012, 12.30pm Rolly Wiegand (Centre for Inflammation Research, QMRI) Abstract: Light microscopy is the most widely used imaging modality in biomedical research and provides scientists with a rapidly developing ‘experimental tool kit’ for basic and clinical research. This talk will summarise some of the technologies, central imaging services and related infrastructure available in different areas of the CMVM. Furthermore, novel cutting-edge light microscopy methods will be highlighted and critically discussed to help identifying potential strategies for future research. This article was published on 2022-10-17
