Centre for Discovery Brain Sciences
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Dr Dirk Sieger

Our research focuses on the role of macrophages and microglia in brain tumour growth.

Dr Dirk Sieger (CRUK Career Establishment Awardee)

Chancellor’s Fellow

  • The Chancellor's Building
  • 49 Little France Crescent
  • EH16 4SB

Contact details

Personal profile

  • 2012 – Principal Investigator, CNR
  • 2009 – 2012 Postdoc, EMBL Heidelberg (Dr. Francesca Peri)
  • 2006 – 2009 Postdoc, University of Cologne (Prof. Maria Leptin)
  • 2002 – 2006 PhD in Genetics, University of Cologne (Prof. Diethard Tautz)

Research Theme

Research 

The lab is mainly interested in the interactions of residential brain macrophages (microglia) and brain tumours. Microglia have the outstanding capability to sense injuries and infections in the brain immediately, to migrate to the site of lesion and to phagocytose detrimental material.

Strikingly a comparable course of events is observed during tumour progression where microglia are attracted to the tumour and colonize the tumour. But instead of the expected anti-tumoural activity they achieve pro-tumoural functions and promote tumour growth. However due to the difficulty to monitor the early events of tumour colonization by microglia in vivo we are just beginning to understand these complex mechanisms.

The optically transparent zebrafish larvae allow us to study the interactions of microglia and brain tumours for the first time in vivo. In particular the opportunity to image cellular interactions at high temporal and spatial resolution in vivo combined with the possibility to interfere genetically and pharmacologically make the zebrafish an ideal model for our research.

Using this new brain tumour model we are approaching the following questions.

  • Which mechanisms are required to attract microglia to the tumour?
  • What are the signals that lead to the pro-tumoural activity of microglia?
  • Is it possible to circumvent the switch to pro-tumoural activity or even to induce anti-tumoural activity?

Team Members

Funding

  • Cancer Research UK
  • Wellcome Trust-University of Edinburgh Institutional Support Fund award (ISSF)

Collaborations

  • Dr Steven Pollard, MRC Centre for Regenerative Medicine, Edinburgh, UK
  • Dr Marina Mione, KIT Karlsruhe, Germany
  • Dr Asier Unciti-Broceta, Edinburgh Cancer Centre
  • Dr Francesca Peri, EMBL Heidelberg, Germany
  • Dr Yi Feng, MRC Centre for Inflammation Research, Edinburgh, UK
  • Dr Catherina Becker, University of Edinburgh, UK
  • Prof David Lyons, University of Edinburgh, UK

Selected Publications

Key Earlier Publications