Centre for Discovery Brain Sciences
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Soraya Meftah

Neurophysiological characterisation of synaptic, neuronal, and network dysfunction in dementia.

Dr Soraya Meftah

Postdoctoral Researcher - Gan lab

  • Chancellor's Building
  • 49 Little France Crescent
  • Edinburgh, EH16 4SB

Contact details

Personal profile

  • 2020 - Present: Postdoctoral Research Fellow, UKDRI, University of Edinburgh.
  • 2016 - 2020: PhD Medical Studies (Neuroscience), University of Exeter & University of Bristol.
  • 2013 - 2016: Molecular Pathology (Histologist). Eli Lilly and Company, Surrey UK.
  • 2011 – 2011: Research Assistant. CNRS, Lyon, France.
  • BSc Biochemistry (Pharmacology), University of Surrey.

Dr Soraya Meftah spent a placement year during her BSc working as a research assistant at the CNRS in Lyon, where she examined the effect of REM sleep deprivation on cataplexy in a model of narcolepsy with Dr Christelle Peyron. Prior to her PhD, Soraya worked at Eli Lilly and Company as a molecular pathologist with a focus on drug discovery for neurodegenerative diseases. She then went on to do her PhD with Dr Jon Brown, Dr Jon Witton & Dr Michael Ashby, examining synaptic and neuronal dysfunction in a model of tauopathy using in vivo and in vitro whole-cell patch clamp electrophysiology, histology, and molecular biology techniques. Currently, she is employed as a postdoctoral research fellow with Dr Jian Gan at the UKDRI in Edinburgh.

Research

My current research involves using in vivo whole-cell patch clamp electrophysiology in combination with other techniques to dissect differences in neuronal and synaptic activity in health and in models of dementia.

Relevant Publications

Jackson J.S., Johnson J.D., Meftah S., Murray T.K., Ahmed Z., Fasiolo M., Hutton M.L., Isaac J.T.R., O’Neill M.J., Ashby M.C. Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy (2020). BioRxiv.

Harrison I. F., Ismail O., Machhada A., Colgan N., Ohene Y., Nahavandi P., Ahmed Z., Fisher A., Meftah S., Murray T.K., Ottersen O.P., Nagelhus E.A., O’Neill M.J., Wells J.A., Lythgoe M.F. Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model (2020). Brain, awaa179.

Roman A., Meftah S., Arthaud S., Luppi P.H., Peyron C. The inappropriate occurrence of rapid eye movement sleep in Narcolepsy is not due to a defect in homeostatic regulation of rapid eye movement sleep (2018). Sleep 41,6.

Blackmore T., Meftah S., Murray T.K., Craig P.J., Blockeel A., Phillips K., Eastwood B., O’Neill M.J., Marston H., Ahmed Z., Gilmour G., Gastambide F. Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy (2017). Alzheimer’s Research & Therapy 9 p.77.

O’Callaghan J., Holmes H., Powell N., Wells J.A., Ismail O., Harrison I.F., Siow B., Johnson R., Ahmed Z., Fisher A., Meftah S., O’Neill M.J., Murray T.K., Collins E.C., Shumeli K., Lythgoe M.F. Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer’s disease (2017). NeuroImage 159 p. 334-345.