Centre for Discovery Brain Sciences
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Dr Makis Tzioras

My work is focused on how astrocytes and microglia in human brains ingest synapses.

Dr Makis Tzioras

Postdoctoral Research Fellow - Spires-Jones Lab

  • 1 George Square
  • Edinburgh
  • EH8 9XD

Contact details

Figure 1. GFAP-positive astrocytes (red) and synaptophysin (green) from human control tissue showing synaptic engulfment. Tissue processed by array tomography.
Figure 1. GFAP-positive astrocytes (red) and synaptophysin (green) from human control tissue showing synaptic engulfment. Tissue processed by array tomography.

Personal Profile

  • Undergraduate degree at University of Edinburgh (BSc Biomedical Sciences, Hons Neuroscience)
  • PhD at University of Edinburgh: “Glial contribution to synaptic ingestion in Alzheimer’s disease and schizophrenia”.

Research

My work is focused on how astrocytes and microglia in human brains ingest synapses. I am exploring this in ageing brains, Alzheimer’s disease and schizophrenia using human post-mortem tissue and novel culturing systems with human biopsies

Relevant Publications 

  • Tzioras, M., Davies, C., Newman, A., Jackson, R. and Spires‐Jones, T., 2018. Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease. Neuropathology and Applied Neurobiology, 45(4), pp.327-346. 10.1111/nan.12529
  • Henstridge, C., Tzioras, M. and Paolicelli, R., 2019. Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration. Frontiers in Cellular Neuroscience, 13. 10.3389/fncel.2019.00063
  • Tzioras, M., Stevenson, A., Boche, D. and Spires‐Jones, T., 2020. Microglial contribution to synaptic uptake in the prefrontal cortex in schizophrenia. Neuropathology and Applied Neurobiology, 47(2), pp.346-351. 10.1111/nan.12660
  • Tzioras, M., Daniels, M., King, D., Popovic, K., Holloway, R., Stevenson, A., Tulloch, J., Kandasamy, J., Sokol, D., Latta, C., Rose, J., Smith, C., Miron, V., Henstridge, C., McColl, B. and Spires-Jones, T., 2019. Altered synaptic ingestion by human microglia in Alzheimer’s disease. BioRXiv https://doi.org/10.1101/795930