I am interested in understanding the mechanisms regulating the growth and refinement of myelinated axons throughout life, and how this is disrupted in neurological diseases.
- Master/PhD Student – Dr. Timothy Kennedy’s Lab, Montreal Neurological Institute/McGill University – September 2008 to August 2015.
- Research Technologist – Dr. Elise Heon’s Lab, Hospital for Sick Children – February 2008 to August 2008.
- Co-op Student Position – Boehringer Ingelheim Canada Ltd – May 2007 to August 2007.
- Co-op Student Position – Hospital for Sick Children – January 2006 to August 2006.
- Co-op Student Position – Health Canada National Microbiology Laboratory – January 2005 to April 2005.
I am interested in understanding the mechanisms regulating the growth and refinement of myelinated axons throughout life, and how this is disrupted in neurological diseases. My current research focuses on the mechanisms controlling myelinated axon caliber growth, and how regulation of axon caliber modulates neuronal circuit function.
Bin JM and Lyons DA. (2016). Imaging Myelination In Vivo Using Transparent Animal Models. Brain Plasticity. 2: 3-39.
Bin JM, Harris SN, and Kennedy TE. (2016). The oligodendrocyte-specific antibody 'CC1' binds Quaking 7. Journal of Neurochemistry. 139: 181-186.
Bin JM*, Han D*, Lai Wing Sun K, Croteau LP, Dumontier E, Cloutier JF, Kania A, and Kennedy TE (2015). Complete Loss of Netrin-1 Results in
Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death. Cell Reports. 12:1099-1106.
Podjaski C, Alvarez JI, Bourbonniere L, Larouche S, Terouz S, Bin JM, Lecuyer MA, Saint-Laurent O, Larochelle C, Darlington P, Arbour N, Antel JP, Kennedy TE, and Prat A. (2015). Netrin-1 Regulates Blood-Brain Barrier Function and Neuroinflammation. Brain. 138:1598-1612.
Bull SJ*, Bin JM*, Beaumont E, Boutet A, Krimpenfort P, Sadikot AF, and Kennedy TE. (2014). Progressive Disorganization of Paranodal Junctions and Compact Myelin Due to Loss of DCC Expression by Oligodendrocytes. J Neuroscience. 34:9768-9778.
Leong SY, Rao VTS, Bin JM, Gris P, Sangaralingam M, Kennedy TE, Antel JP. (2014). Heterogeneity of oligodendrocyte progenitor cells in adult human brain. Annal Clin Translat Neurol. 1: 272-283.
Bin JM*, Rajasekharan S*, Kuhlmann T, Hanes I, Marcal N, Han D, Rodrigues SP, Leong SY, Newcombe J, Antel JP, and Kennedy TE. (2013). Full-Length and Fragmented Netrin-1 in Multiple Sclerosis Plaques are Inhibitors of Oligodendrocyte Precursor Cell Migration. Am J Pathol. 183:673-680.
Bin JM, Leong SY, Bull SJ, Antel JP, and Kennedy TE. (2012) Oligodendrocyte Precursor Cell Transplantation into Organotypic Cerebellar Shiverer Slices: A Model to Study Myelination and Myelin Maintenance. PLoS One. 7(7):e41237.
de Faria O, Cui Q, Bin JM, Bull SJ, Kennedy TE, Bar-Or A, Antel JP, Colman DR, and Dhaunchak AS. (2012). Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes. Front Genet. 3:46.
Rajasekharan S, Bin JM, Antel JP, and Kennedy TE (2010). A Central Role for RhoA during Oligodendroglial Maturation in the Switch from Netrin-1 Mediated Chemorepulsion to Process Elaboration. J Neurochem. 113:1589-1597.
* Indicates co-first authorship