Centre for Discovery Brain Sciences
Centre for Discovery Brain Sciences Transparent Logo

Synapses, Circuits and Behaviour

The Research Theme is studying the cellular and circuit mechanisms underpinning nervous system functions.

Neurons are the fundamental building blocks of the nervous system and unravelling the mechanisms that regulate neuronal excitability, communication and plasticity is key to understanding how the nervous system controls complex behaviours.

In this research theme, investigators exploit advanced imaging, electrophysiological, molecular genetic and quantitative behavioural approaches to understand the cellular and circuit mechanisms underpinning nervous system functions such as sensory perception, memory formation and the control of complex, adaptable behaviours in the healthy and diseased brain.

Our aim is to translate fundamental discoveries, through development of animal- and human-based models, to generate transformative therapeutic interventions for disorders that affect nervous system function.

Theme Lead: Prof Ian Duguid

Name Research interest
Brunton, Paula Stress Physiology
Busch, Emanuel Physiology and genetics of sensory neural circuits in C. elegans
Cobb, Stuart  Novel therapies for neurodevelopmental disorders
Cousin, Michael Presynaptic Cell Biology
Daw, Michael Developmental Physiology of the Barrel Cortex
Duguid, Ian Neural circuits and motor behaviour
Dutia, Mayank The vestibular system and cerebellum
Evans, Mark Calcium signalling & hypoxia-response coupling
Fleetwood-Walker, Susan Molecular mechanisms of pain and analgesia
Gillingwater, Tom New therapies for neurodegenerative diseases
Gkogkas, Christos Translational control in neuropsychiatric diseases
Greiss, Sebastian Genetic code expansion and neural circuits  
Hardingham, Giles Protective & degenerative signalling in the CNS
Kind, Peter Disorders of Brain Development  
Livesey, Matthew Human stem cell models of neurological disease 
Lyons, David Mechanisms of myelinated axon formation, function and repair
Morris, Richard

Neurobiology of learning and memory

Mitchell, Rory Receptor-mediated signal transduction
Nolan, Matthew Neural circuits and computation
Olverman, Henry Human mood disorders
Oren, Iris Memory and diseases
Osterweil, Emily mRNA translation and synaptic connections
Ribchester, Richard Neuromuscular connections
Rochefort, Nathalie Neuronal processing of visual information  
Shipston, Mike Ion channel physiology
Smillie, Karen Synaptic vesicle recycling
Spires-Jones, Tara Degenerative brain diseases and ageing
Stefan, Melanie Understanding of learning and memory
Torsney, Carole Somatosensory plasticity
Wood, Emma Memory and Space
Wyllie, David Physiology and pharmacology of ion channels
Zhang, HongYan Locomotor control and rhythm generation in simple animal model systems