Completed projects

ENCHANTED

Enhanced Control of Hypertension & Thrombolysis Stroke Study

• Randomised-controlled trial comparing the following acute treatments for ischaemic stroke:

  1. Low dose IV alteplase versus standard dose
  2. Intensive blood pressure lowering versus standard care

IST-3

Third International Stroke Trial

• Randomised-controlled trial of IV alteplase versus control. Main publication, trial protocol.
• Imaging substudy of arterial patency & brain perfusion. Main publication, trial protocol

PISCES-II

Phase IIa clinical trial in stroke disability

• PISCES II is a single arm, open-label study in patients living with disability resulting from ischaemic stroke. 

• A randomised controlled clinical trial of adjunctive mechanical thrombectomy compared with intravenous thrombolysis in patients with acute ischaemic stroke due to an occluded major intracranial vessel.

Preventing cognitive decline & dementia from cerebral small vessel disease. (LACunar Intervention Trial-1)

• The trial hypothesis is to test whether a much larger scale study testing the effects of Cilostazol & ISMN on preventing brain damage from small vessel disease will be feasible.

RIGHT-2

Rapid intervention with Glyceryl trinitrate in Hypertensive stroke trial-2

• GTN in acute stroke.