Edinburgh Imaging

MSc projects 1516 008

Systematic review of myocardial computed tomography perfusion techniques & its clinical applications.

  • Background: Myocardial CT perfusion (MCTP) imaging is a novel, non-invasive imaging modality offering high spatial and temporal resolution. MCTP includes both static and dynamic perfusion imaging with a successful scan involving adequate patient preparation and utilisation of correct scanning protocols. MCTP has a growing role in the clinical setting from the evaluation of patients presenting with chest pain, detection of coronary stenosis as well as the assessment of myocardial perfusion deficits.
  • Methods: We identified published studies on MCTP through a systematic review of PubMed and Embase from inception to March 2016. Our inclusion criteria were original research studies with more than five patients and comparative studies, comparing MCTP against other imaging modalities.
  • Results: Our search yielded 1467 abstracts with a total of twenty-five articles selected for final analysis. A substantial number were excluded since they were not related to CT perfusion. Results were assessed according to CT perfusion technique, namely static stress CT perfusion (single and dual source) as well the dynamic stress CT perfusion
  • Conclusion: Static (single-dual source) and dynamic CT perfusion imaging were noted to safe and feasible CT techniques despite considerable technical variation between trials. Furthermore these techniques had comparable sensitivity and specificity with existing gold standard techniques including SPECT, PET and CMR. Standardisation of MCTP techniques will be vital for future studies and meta-analysis. Finally, further validation of clinical applications of MCTP is needed in the form of randomised controlled trials and against other imaging modalities.
Project type:
  • Systematic review
Imaging keywords:
  • CT perfusion imaging
  • Dynamic perfusion imaging
  • Myocardial computed tomography perfusion (MCTP)
  • Perfusion defect
Application / disease keywords:
  • 15-16