Edinburgh Imaging

MSc projects 1213 002

Investigating the role of neuroimaging in mild cognitive impairment (MCI): progress in the last decade.

  • Aims: To explore the current academic opinion regarding the role of neuroimaging techniques in investigating and diagnosing MCI and how these techniques have enhanced our knowledge of the concept of MCI and ‘pre-dementia ‘ states over the last decade. To explore to what extent advancements in this field of research have translated into clinical practice and contribute in practical terms to establishment of a diagnosis of MCI in patients attending memory clinics.

  • Methods: This project incorporates a literature review and a pilot substudy.  As part of the literature review, an electronic database search of Medline for relevant articles published on the topic between 2002 and 2012 was undertaken in order to explore the role of neuroimaging in MCI over the last decade. The pilot study was undertaken in a national memory clinic, where 600 patients with memory complaints are reviewed annually. The objective of the pilot study component of this project is to investigate to what extent academic advancements have impacted on everyday clinical practice and contribute practically and realistically to establishment of a diagnosis of MCI in patients undergoing investigations for memory complaints.

  • Conclusions: This project highlighted that there has been significant growth in the past decade, in scientific knowledge regarding the existence of neuroimaging biomarkers and their role in investigating and diagnosing mild cognitive impairment. The pilot substudy revealed that within a national memory clinic, neuroimaging appears to significantly contribute in clinical practice on a daily basis. However many advances made within the field of academia have yet to translate to a material extent, into everyday practice.

Project type:
  • Pilot substudy
  • Systematic review
Imaging keywords:
Application / disease keywords:
  • Dementia
  • Mild cognitive impairment (MCI)
  • Dr Sarah Keir
  • 12-13