Edinburgh Reproductive Tissue Biobank


Output from 2010 to 2015.

Publications arising 2015

Forbes S, Barr SM, Reynolds RM, Semple S, Gray C, Andrew R, Denison FC, Walker BR, Norman JE. Convergence in insulin resistance between very severely obese and lean women at the end of pregnancy. Diabetologia. 2015 Nov;58(11):2615-26. doi: 10.1007/s00125-015-3708-3.

Mohd-Shukri NA, Duncan A, Denison FC, Forbes S, Walker BR, Norman JE, Reynolds RM. Health Behaviours during Pregnancy in Women with Very Severe Obesity. Nutrients. 2015 Oct 7;7(10):8431-43. doi: 10.3390/nu7105403.

Stirrat LI, O’Reilly JR, Barr SM, Andrew R, Riley SC, Howie AF, Bowman M, Smith R, Lewis JG, Denison FC, Forbes S, Seckl JR, Walker BR, Norman JE, Reynolds RM. Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery. Psychoneuroendocrinology. 2015 Sep 25;63:135-143. doi: 10.1016/j.psyneuen.2015.09.019.

Mina TH, Riley SC, Norman JE, Reynolds RM. Placental mRNA levels of genes regulating fetal glucocorticoid and neurotransmitter exposure correlate with birth size, but not in very severely obese pregnancy. Psychoneuroendocrinology. 2015 Nov;61:15. doi: 10.1016/j.psyneuen.2015.07.428.

Denison FC, Weir Z, Carver H, Norman JE, Reynolds RM. Physical activity in pregnant women with Class III obesity: A qualitative exploration of attitudes and behaviours. Midwifery. 2015 Aug 21. pii: S0266-6138(15)00213-2. doi: 10.1016/j.midw.2015.08.006.

Chiswick C, Reynolds RM, Denison F, Drake AJ, Forbes S, Newby DE, Walker BR, Quenby S, Wray S, Weeks A, Lashen H, Rodriguez A, Murray G, Whyte S, Norman JE. Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2015 Oct;3(10):778-86. doi: 10.1016/S2213-8587(15)00219-3.

Stirrat LI, O’Reilly JR, Riley SC, Howie AF, Beckett GJ, Smith R, Walker BR, Norman JE, Reynolds RM. Altered maternal hypothalamic-pituitary-adrenal axis activity in obese pregnancy is associated with macrosomia and prolonged pregnancy. Pregnancy Hypertens. 2014 Jul;4(3):238. doi: 10.1016/j.preghy.2014.03.028.

Piyasena C, Reynolds RM, Khulan B, Seckl JR, Menon G, Drake AJ. Placental 5-methylcytosine and 5-hydroxymethylcytosine patterns associate with size at birth. Epigenetics. 2015;10(8):692-7. doi: 10.1080/15592294.2015.1062963.

Mina TH, Denison FC, Forbes S, Stirrat LI, Norman JE, Reynolds RM. Associations of mood symptoms with ante- and postnatal weight change in obese pregnancy are not mediated by cortisol. Psychol Med. 2015 Nov;45(15):3133-46. doi: 10.1017/S0033291715001087.

Mina TH, Räikkönen K, Riley SC, Norman JE, Reynolds RM. Maternal distress associates with placental genes regulating fetal glucocorticoid exposure and IGF2: Role of obesity and sex. Psychoneuroendocrinology. 2015 Sep;59:112-22. doi: 10.1016/j.psyneuen.2015.05.004.

Rajagopal SP, Hutchinson JL, Dorward DA, Rossi AG, Norman JE. Crosstalk between monocytes and myometrial smooth muscle in culture generates synergistic pro-inflammatory cytokine production and enhances myocyte contraction, with effects opposed by progesterone. Mol Hum Reprod. 2015 Aug;21(8):672-86. doi: 10.1093/molehr/gav027.

Rinaldi SF, Rossi AG, Saunders PT, Norman JE. Immune cells and preterm labour: do invariant NKT cells hold the key? Mol Hum Reprod. 2015 Apr;21(4):309-12. doi: 10.1093/molehr/gav002.

Chiswick CA, Reynolds RM, Denison FC, Whyte SA, Drake AJ, Newby DE, Walker BR, Forbes S, Murray GD, Quenby S, Wray S, Norman JE. Efficacy of metformin in pregnant obese women: a randomised controlled trial. BMJ Open. 2015 Jan 14;5(1):e006854. doi: 10.1136/bmjopen-2014-006854.

Voltolini C, Battersby S, Novembri R, Torricelli M, Severi FM, Petraglia F, Norman JE. Urocortin 2 role in placental and myometrial inflammatory mechanisms at parturition. Endocrinology. 2015 Feb;156(2):670-9. doi: 10.1210/en.2014-1432.

Piyasena C, Cartier J, Khulan B, French K, Menon G, Seckl JR, Reynolds RM, Drake AJ. Dynamics of DNA methylation at IGF2 in preterm and term infants during the first year of life: an observational study. Lancet. 2015 Feb 26;385 Suppl 1:S81. doi: 10.1016/S0140-6736(15)60396-8.

Publications arising 2014

Frew L, Makieva S, McKinlay AT, McHugh BJ, Doust A, Norman JE, Davidson DJ, Stock SJ. Human cathelicidin production by the cervix. PLoS One. 2014 Aug 4;9(8):e103434. doi: 10.1371/journal.pone.0103434.

Moyes AJ, Gray GA, Denison FC. Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia. Hypertens Pregnancy. 2014 May;33(2):177-90. doi: 10.3109/10641955.2013.846368.

Hutchinson JL, Rajagopal SP, Yuan M, Norman JE. Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways. FASEB J. 2014 Jan;28(1):94-105. doi: 10.1096/fj.13-237040.

Publications arising 2013

Hutchinson JL, Rajagopal SP, Yuan M, Norman JE.  Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways.  FASEB J. 2013 Sep 27. [Epub ahead of print]

Frew L, Sugiarto NU, Rajagopal SP, He J, Leask R, Norman JE, Riley SC, Stock SJ (2013) The effect of omega-3 polyunsaturated fatty acids on the inflammatory response of the amnion. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2013 Sep;89(4):221-5. doi: 10.1016/j.plefa.2013.07.001. http://dx.doi.org/10.1016/j.plefa.2013.07.001

Modelling chorionic villus sampling technique: influence of number of needle ‘passes’ on quantity of chorionic villi obtained. Skorupskaite K, Walker J, Stock S. Ultrasound Obstet Gynecol. 2013 May;41(5):592-3. doi: 10.1002/uog.12326

Mohd-Shukri NA, Bolton JL, Norman JE, Walker BR, Reynolds RM.  Evaluation of an FFQ to assess total energy and nutrient intakes in severely obese pregnant women. Public Health Nutr. 2013 Aug;16(8):1427-35. doi: 10.1017/S136898001200417X.

Publications arising 2012

Voltolini C, Battersby S, Etherington SL, Petraglia F, Norman JE, Jabbour HN. A novel antiinflammatory role for the short-chain fatty acids in human labor. Endocrinology. 2012 Jan;153(1):395-403. doi: 10.1210/en.2011-1457.

Logie JJ, Denison FC, Riley SC, Ramaesh T, Forbes S, Norman JE, Reynolds RM. Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre-eclampsia. Clin Endocrinol (Oxf). 2012 Jun;76(6):887-93. doi: 10.1111/j.1365-2265.2011.04317.x.

Denison FC, Semple SI, Stock SJ, Walker J, Marshall I, Norman JE.  Novel use of proton magnetic resonance spectroscopy (1HMRS) to non-invasively assess placental metabolism. PLoS One. 2012;7(8):e42926. doi: 10.1371/journal.pone.0042926.

Publications arising 2011

Maldonado-Perez D, Golightly E, Denison FC, Jabbour HN, Norman JE. A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturition. FASEB Journal 2011; 25:569-575.

Gorowiec MR, Catalano RD, Norman JE, Denison FC, Jabbour HN. Prokineticin 1 (PROK1) induces inflammatory response in human myometrium: a potential role in initiating term and preterm parturition. American Journal of Pathology 2011; 179:2709-19

Roberts KA, Riley SC, Reynolds RM, Barr S, Evans M, Statham A, Hor K, Jabbour HN, Norman JE, Denison FC. Placental structure and inflammation in pregnancies associated with obesity. Placenta 2011;32:247-254.

Moyes AJ, Maldonado-Perez D, Gray GA, Denison FC. Enhanced angiogenic capacity of human umbilical vein endothelial cells from women with preeclampsia.  Reproductive Science 2011; 18:374-382.

Norman JE, Yuan M, Anderson L, Howie F, Harold G, Young A, Jordan F, McInnes I, Harnett MM. Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels. Reproductive Science 2011;18:435-446.

Publications arising 2010

Reynolds RM, Osmond C, Phillips DI, Godfrey KM. Maternal BMI, parity, and pregnancy weight gain: influences on offspring adiposity in young adulthood. Journal of Clinical Endocrinology and Metabolism 2010; 95:5365-5369.

Ramaesh T, Logie JJ, Roseweir AK, Millar RP, Walker BR, Hadoke PW, Reynolds RM. Kisspeptin-10 inhibits angiogenesis in human placental vessels ex vivo and endothelial cells in vitro. Endocrinology 2010; 151:5927-5934.

Robb AO, Din JN, Mills NL, Smith IB, Blomberg A, Zikry MN, Raftis JB, Newby DE, Denison FC. The influence of the menstrual cycle, normal pregnancy and pre-eclampsia on platelet activation. Thrombosis and Haemostasis; 2010; 103:372-378.

Catalano RD, Lannagan TR, Gorowiec M, Denison FC, Norman JE, Jabbour HN. Prokineticins: novel mediators of inflammatory and contractile pathways at parturition? Molecular Human Reproduction 2010; 16:311-319.

Trainees who have received tissue samples and / or data from the ERTBB for their projects up to December 2015

  • 18 PhD students
  • 16 “MSc by Research in Reproductive Biology” students
  • 14 “Honours in Reproductive Biology” students
  • 9 Student Selected Component undergraduate medical students