Dr Susana Muñoz Maniega
- Centre for Clinical Brain Sciences
- Edinburgh Imaging
- Row Fogo Centre
Contact details
- Email: s.m.maniega@ed.ac.uk
Past PhD students supervised
Dr Angela Jochems
Research summary
I employ diffusion MRI for the measurement of white matter integrity and for the reconstruction of white matter pathways, the “wiring” in the brain.
My major interest is the use of quantitative MRI to study in vivo the effects of cerebrovascular disease, and ageing in general, on the brain's white matter. I process and analyse the imaging data from the Lothian Birth Cohort 1936 (LBC1936), a longitudinal study of cognitive ageing.
LBC1936 has a wide range of variables: genome-wide genotyping, demographics, psycho-social and lifestyle factors, cognitive functions, medical history and examinations, biomarkers (from blood and urine) and a detailed structural MRI brain scan. The imaging side of the project has a specific focus on finding how the white matter of the brain becomes damaged and provides important insights into the structural changes that occur in the brain during aging, and how these changes are related to cognitive ability and genetic factors.
I also collaborate on the MRI image processing and analysis of other research projects in cerebrovascular disease, such as the Mild Stroke Study 3 and INVESTIGATE@SVDs
Project activity
“Lothian Birth Cohort 1936” longitudinal study, funded by Age UK and the Medical Research Council.
https://www.ed.ac.uk/lothian-birth-cohorts
Small Vessel Diseases (SVDs).
https://www.ed.ac.uk/clinical-brain-sciences/research/row-fogo-centre/our-research/research-projects
-
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
(13 pages)
In:
Nature Medicine, vol. 29, pp. 950-962
DOI: https://doi.org/10.1038/s41591-023-02268-w
Research output: Contribution to Journal › Article (Published) -
Sleep quality, perivascular spaces and brain health markers in ageing - A longitudinal study in the Lothian Birth Cohort 1936
In:
Sleep medicine
DOI: https://doi.org/10.1016/j.sleep.2023.03.016
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults?: Evidence from the Lothian Birth Cohort 1936
In:
International Journal of Geriatric Psychiatry, vol. 38
DOI: https://doi.org/10.1002/gps.5855
Research output: Contribution to Journal › Article (Published) -
Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease
In:
Journal of Cerebral Blood Flow and Metabolism
DOI: https://doi.org/10.1177/0271678X221135658
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Longitudinal changes of white matter hyperintensities in sporadic small vessel disease: a systematic review and meta-analysis
In:
medrXiv
DOI: https://doi.org/10.1101/2022.03.22.22272696
Research output: Contribution to Journal › Article (E-pub ahead of print)