Dr Donncha Dunican
Investigator Scientist
- MRC Human Genetics Unit
- MRC Institute of Genetics and Molecular Medicine
Contact details
- Tel: +44 (0) 131 651 8651
- Email: donncha.dunican@igmm.ed.ac.uk
Address
- Street
-
MRC Human Genetics Unit,
MRC Institute of Genetics and Molecular Medicine,
The University of Edinburgh,
Western General Hospital,
Crewe Road,
EDINBURGH,
EH4 2XU - City
- Post code
Background
Donncha Dunican received his Honours Degree in Biochemistry from NUIGalway (Ireland) during which he became interested in recombinant DNA technology. He relocated to Trinity College Dublin to pursue a PhD in Cancer Transcriptomics (Prof. David Croke) discovering alterations in epigenetic regulators between familial and sporadic colon cancers. In 2001, Donncha moved to Scotland as a postdoctoral fellow studying gene expression in frog embryos lacking DNA methylation (Prof. Richard Meehan). In 2004, Donncha started a Career Development Fellowship at the MRC Human Genetics Unit where he transitioned to study epigenetics in mammalian systems. Donncha was promoted to Investigator Scientist in 2008 and is focused on determining the mechanisms underlying de novo and maintenance DNA methylation.
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Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes
In:
Nucleic Acids Research
DOI: https://doi.org/10.1093/nar/gkaa529
Research output: Contribution to Journal › Article (Published) -
Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells
In:
BMC Biology, vol. 18
DOI: https://doi.org/10.1186/s12915-020-0752-3
Research output: Contribution to Journal › Article (Published) -
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome
(11 pages)
In:
Nature Genetics, vol. 49, pp. 238-248
DOI: https://doi.org/10.1038/ng.3743
Research output: Contribution to Journal › Article (Published) -
Lsh is essential for maintaining global DNA methylation levels in amphibia and fish and interacts directly with Dnmt1
In:
BioMed Research International
DOI: https://doi.org/10.1155/2015/740637
Research output: Contribution to Journal › Article (Published) -
Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems
(17 pages)
In:
Genome Biology, vol. 16
DOI: https://doi.org/10.1186/s13059-014-0576-y
Research output: Contribution to Journal › Article (Published) -
Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline
In:
Cellular and Molecular Life Sciences, vol. 71, pp. 1581-1605
DOI: https://doi.org/10.1007/s00018-013-1468-0
Research output: Contribution to Journal › Literature review (Published) -
Lsh regulates LTR retrotransposon repression independently of Dnmt3b function
In:
Genome Biology, vol. 14, pp. R146
DOI: https://doi.org/10.1186/gb-2013-14-12-r146
Research output: Contribution to Journal › Article (Published) -
Senescent cells harbour features of the cancer epigenome
In:
Nature Cell Biology
DOI: https://doi.org/10.1038/ncb2879
Research output: Contribution to Journal › Article (Published) -
Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques
In:
Nucleic Acids Research
DOI: https://doi.org/10.1093/nar/gkt1080
Research output: Contribution to Journal › Article (Published) -
Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer
In:
Nucleic Acids Research, vol. 41, pp. 6857-6869
DOI: https://doi.org/10.1093/nar/gkt438
Research output: Contribution to Journal › Article (Published) -
The CXXC-TET bridge--mind the methylation gap!
(2 pages)
In:
Cell Research (CR), vol. 23, pp. 973-4
DOI: https://doi.org/10.1038/cr.2013.71
Research output: Contribution to Journal › Editorial (Published) -
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
(17 pages)
In:
Genome Biology, vol. 14
DOI: https://doi.org/10.1186/gb-2013-14-3-r25
Research output: Contribution to Journal › Article (Published) -
Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline
(10 pages)
In:
Development, vol. 139, pp. 3623-3632
DOI: https://doi.org/10.1242/dev.081661
Research output: Contribution to Journal › Article (Published) -
Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes
(11 pages)
In:
Genome Research, vol. 22, pp. 467-477
DOI: https://doi.org/10.1101/gr.126417.111
Research output: Contribution to Journal › Article (Published) -
Apoptosis and DNA methylation
(23 pages)
In:
Cancers, vol. 3, pp. 1798-820
DOI: https://doi.org/10.3390/cancers3021798
Research output: Contribution to Journal › Article (Published) -
Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA
(3 pages)
In:
Biotechniques, vol. 48, pp. 317-319
DOI: https://doi.org/10.2144/000113403
Research output: Contribution to Journal › Article (Published) -
MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos
(10 pages)
In:
Development, vol. 136, pp. 2277-86
DOI: https://doi.org/10.1242/dev.032227
Research output: Contribution to Journal › Article (Published) -
The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways
(5 pages)
In:
Development, vol. 136, pp. 723-727
DOI: https://doi.org/10.1242/dev.025577
Research output: Contribution to Journal › Article (Published) -
xDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic function
(8 pages)
In:
Development, vol. 135, pp. 1295-302
DOI: https://doi.org/10.1242/dev.016402
Research output: Contribution to Journal › Article (Published) -
Epigenetic modification of chromatin
(24 pages)
DOI: https://doi.org/10.1017/CBO9780511543555.003
Research output: › Chapter (Published)