Bubble CPAP for treatment of Bangladeshi children with severe pneumonia
This project is based at icddr,b in Bangladesh
- Project title: Feasibility and acceptability followed by effectiveness of bubble continuous positive airway pressure for treatment of Bangladeshi children with severe pneumonia
- Acute or chronic: Acute
- Based at: icddr,b
- Start date: 01 September 2018
- End date: 31 December 2020
- Principal investigator: Mohammod Jobayer Chisti
- Project team: Mohammod Jobayer Chisti, John D. Clemens, Shams El Arifeen, Tahmeed Ahmed, Trevor Duke, Harry Campbell, Harish Nair, Steve Cunningham, Kathrin Cresswell, KM Shahunja, Ahmed Ehsanur Rahman, ASG Faruque, Fakhar Uddin, Abu SMSB Shahid, Aziz Sheikh
Hypoxaemia, a low level of oxygen in the blood, is one of the main risk factors for death due to pneumonia among children.
District hospitals in Bangladesh are considered as secondary level referral hospitals and usually provide care of paediatric patients in paediatric wards, including children with pneumonia and severe pneumonia.
District hospitals do not have additional respiratory support available to children who are failing to improve following treatment with low-flow oxygen supplementation, the World Health Organization standard. As a result, these children may die due to lack of availability of additional respiratory support.
Bubble CPAP (a low-cost, locally made device to deliver oxygen) improved survival rates when provided to treat severe pneumonia in tertiary hospitals. This study will explore whether the same technology made available in district hospitals could provide the same patient benefit.
Aim and impact
This study aims to explore whether bubble CPAP is able to improve outcomes of children with severe pneumonia and hypoxaemia who receive care in non-tertiary, district hospitals. We also aim to understand the feasibility and acceptability of introducing and using locally made innovative low-cost bubble CPAP in these real-life settings in two selected district hospitals, prior to commencing our multicentre trial.
The results of this study will provide cohesive support to deliver a trial of bubble CPAP as an intervention for acute lower respiratory tract infection with hypoxaemia in children attending district hospitals. The next step is to aid the scale up of this low-cost intervention, to reduce pneumonia-related deaths in low- and middle-income countries across the globe.
- Various media coverage including
- The Economist, Read 'How a shampoo bottle is saving young lives' on The Economist
- BBC, Watch 'The doctor who turned a shampoo bottle into a low cost lifesaver' on the BBC website
- CNN, Watch 'The plastic bottle saving babies from pneumonia' on YouTube
- Channel i (led by freedom fighters of 1991 in Bangladesh), Watch the coverage on Vimeo
- Funding was secured from Bill and Melinda Gates Foundation (BMGF) for a two-day workshop on “bCPAP in Low Income Settings Data Synthesis and Meta-analysis” in Edinburgh in January 2019.
- Submitted ethics application to the Liverpool School of Tropical Medicine Research Ethics Committee for approval.
- Potential study sites have been visited and two sites have been selected (two district hospitals of Bangladesh).
- A dissemination seminar was held with local stakeholders on 16 July 2019.