Usher Institute

The impact of COVID-19 vaccines in pregnancy, children and young people, and vulnerable groups (DaC-VaP-2)

Awarded through a funding call by Health Data Research UK and the Alan Turing Institute, and led by Professor Aziz Sheikh, this project works to use UK-wide data to study the uptake, safety and effectiveness of COVID-19 vaccines.

DaC-VaP logo

Summary (Research in a nutshell)

There are many questions that need to be answered about the safety and effectiveness of COVID-19 vaccines.

Building on our earlier work, we engaged with a range of patient, public, community, professional and health policy groups who told us the following questions are the most important to them:

‘What is the uptake, safety and effectiveness of COVID-19 vaccines’: for the following groups:

  1. in pregnancy
  2. in children and young people
  3. when given as booster doses
  4. on disease caused by different variants?'

We will research the answers to the questions. The research will use linked datasets from across the UK. These will include general practitioner, vaccination, testing, viral sequencing, hospitalisation and death data. Trained, approved data analysts will have access to the data in secure and safe settings. This means people can be confident that health data is being accessed securely and privacy protected.

We will be able to replicate findings in different national data sources and pool results on up to 55 million people across the UK.

This work is beneficial to the public. Our patient and public involvement work has shown the importance of these questions. Our work will help to increase the confidence of the public in the COVID-19 vaccines.

We will continue to work with the UK’s Chief Medical Officers, Chief Scientific Advisers, and government and vaccine bodies—in particular, the Joint Committee on Vaccination and Immunisation, and the Medicines and Healthcare products Regulatory Agency—so they are aware of our work and they will be ready to use our results to inform national decisions that benefit the public.

Key people

Name Role Affiliation
Aziz Sheikh Senior Investigator University of Edinburgh /  BREATHE - Health Data Research Hub for Respiratory Health / EAVE II
Simon de Lusignan Senior Investigator - England University of Oxford / Royal College of General Practitioners Research Surveillance Centre
Richard Hobbs Senior Investigator - England University of Oxford
Jenni Quint Senior Investigator - England Imperial College London / BREATHE - Health Data Research Hub for Respiratory Health
Vahe Nafilyan Senior Investigator - England Office for National Statistics
Mark Joy Core researcher - England University of Oxford
Chris Robertson Senior Investigator - Scotland University of Strathclyde / PHS / EAVE II
Steven Kerr Core researcher - Scotland University of Edinburgh
Declan Bradley Senior Investigator - Northern Ireland Queen’s University Belfast / Public Health Agency
Dermot O’Reilly Senior Investigator - Northern Ireland Queen’s University Belfast
Siobhan Murphy Core researcher - Northern Ireland Queen’s University Belfast
Ronan Lyons Senior Investigator - Wales Swansea University / SAIL Databank
Ashley Akbari Senior Investigator - Wales Swansea University / SAIL Databank
Stuart Bedston Core researcher - Wales Swansea University
Antony Chuter Patient and Public Involvement Lead  
Jillian Beggs Patient and Public Involvement Lead  
Tracy Jackson Patient and Public Involvement Research Fellow University of Edinburgh
Susan Buckingham Communications and Engagement Manager University of Edinburgh
Dominique Balharry Research Manager University of Edinburgh
Morag Edwards Research Administrator University of Edinburgh

Key publications

This project builds on the first DaC-VaP project which ran from January to October 2021. The DaC-VaP team have contributed to publications that have informed the UK and Scottish Government responses to the pandemic, as well as our understanding of the effectiveness of COVID-19 vaccines.

Read more on the EAVE II website

Timeline

November 2021 – September 2022

Key Collaborations

BREATHE - Health Data Research Hub for Respiratory Health

EAVE II - Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 study

Health Data Research UK

Imperial College London

Office for National Statistics

Queen's University Belfast

Royal College of General Practitioners Research Surveillance Centre

Swansea University

SAIL Databank

University of Oxford

University of Strathclyde

Partners and Funders

This project is part of the Data and Connectivity National Core Study - working to make vital data available to accelerate research on COVID-19.  Data and Connectivity is led by Health Data Research UK, in partnership with the Office for National Statistics, funded by UK Research and Innovation and delivered alongside a UK-wde network of delivery partners. This work was also supported by The Alan Turing Institute via 'Towards Turing 2.0' EPSRC Grant Funding.

HDR UK ONS and Alan Turing logos
Press and PR

The University of Edinburgh

Tel: +44 (0)7979 446 209

Email: press.office@ed.ac.uk

 

All other enquiries

Project manager: Dominique Balharry, University of Edinburgh

d.balharry@ed.ac.uk

 

Scientific themes

COVID-19, Vaccine Pharmacovigilance, Pregnancy, Boosters, Variants