The impact of COVID-19 vaccines in pregnancy, children and young people, and vulnerable groups (DaC-VaP-2)
Awarded through a funding call by Health Data Research UK and the Alan Turing Institute, and led by Professor Aziz Sheikh, this project works to use UK-wide data to study the uptake, safety and effectiveness of COVID-19 vaccines.
Summary (Research in a nutshell)
There are many questions that need to be answered about the safety and effectiveness of COVID-19 vaccines.
Building on our earlier work, we engaged with a range of patient, public, community, professional and health policy groups who told us the following questions are the most important to them:
‘What is the uptake, safety and effectiveness of COVID-19 vaccines’: for the following groups:
- in pregnancy
- in children and young people
- when given as booster doses
- on disease caused by different variants?'
We will research the answers to the questions. The research will use linked datasets from across the UK. These will include general practitioner, vaccination, testing, viral sequencing, hospitalisation and death data. Trained, approved data analysts will have access to the data in secure and safe settings. This means people can be confident that health data is being accessed securely and privacy protected.
We will be able to replicate findings in different national data sources and pool results on up to 55 million people across the UK.
This work is beneficial to the public. Our patient and public involvement work has shown the importance of these questions. Our work will help to increase the confidence of the public in the COVID-19 vaccines.
We will continue to work with the UK’s Chief Medical Officers, Chief Scientific Advisers, and government and vaccine bodies—in particular, the Joint Committee on Vaccination and Immunisation, and the Medicines and Healthcare products Regulatory Agency—so they are aware of our work and they will be ready to use our results to inform national decisions that benefit the public.
|Aziz Sheikh||Senior Investigator||University of Edinburgh / BREATHE - Health Data Research Hub for Respiratory Health / EAVE II|
|Simon de Lusignan||Senior Investigator - England||University of Oxford / Royal College of General Practitioners Research Surveillance Centre|
|Richard Hobbs||Senior Investigator - England||University of Oxford|
|Jenni Quint||Senior Investigator - England||Imperial College London / BREATHE - Health Data Research Hub for Respiratory Health|
|Vahe Nafilyan||Senior Investigator - England||Office for National Statistics|
|Mark Joy||Core researcher - England||University of Oxford|
|Chris Robertson||Senior Investigator - Scotland||University of Strathclyde / PHS / EAVE II|
|Steven Kerr||Core researcher - Scotland||University of Edinburgh|
|Declan Bradley||Senior Investigator - Northern Ireland||Queen’s University Belfast / Public Health Agency|
|Dermot O’Reilly||Senior Investigator - Northern Ireland||Queen’s University Belfast|
|Siobhan Murphy||Core researcher - Northern Ireland||Queen’s University Belfast|
|Ronan Lyons||Senior Investigator - Wales||Swansea University / SAIL Databank|
|Ashley Akbari||Senior Investigator - Wales||Swansea University / SAIL Databank|
|Stuart Bedston||Core researcher - Wales||Swansea University|
|Antony Chuter||Patient and Public Involvement Lead|
|Jillian Beggs||Patient and Public Involvement Lead|
|Tracy Jackson||Patient and Public Involvement Research Fellow||University of Edinburgh|
|Susan Buckingham||Communications and Engagement Manager||University of Edinburgh|
|Dominique Balharry||Research Manager||University of Edinburgh|
|Morag Edwards||Research Administrator||University of Edinburgh|
This project builds on the first DaC-VaP project which ran from January to October 2021. The DaC-VaP team have contributed to publications that have informed the UK and Scottish Government responses to the pandemic, as well as our understanding of the effectiveness of COVID-19 vaccines.
November 2021 – September 2022
Partners and Funders
This project is part of the Data and Connectivity National Core Study - working to make vital data available to accelerate research on COVID-19. Data and Connectivity is led by Health Data Research UK, in partnership with the Office for National Statistics, funded by UK Research and Innovation and delivered alongside a UK-wde network of delivery partners. This work was also supported by The Alan Turing Institute via 'Towards Turing 2.0' EPSRC Grant Funding.
Press and PR
The University of Edinburgh
Tel: +44 (0)7979 446 209
All other enquiries
Project manager: Dominique Balharry, University of Edinburgh
COVID-19, Vaccine Pharmacovigilance, Pregnancy, Boosters, Variants