Co-OPT: consortium for the study of pregnancy treatments
A new collaborative consortium for the study of pregnancy treatments.
Summary (Research in a nutshell)
50% of pregnant women are prescribed drugs in pregnancy, but there are significant knowledge gaps about the safety, optimum dosage and long-term effects of medications in pregnancy.
Co_OPT will address these knowledge gaps through individual patient data level meta-analysis and data linkage studies with data extracted from electronic health records and contributed from birth registries, cohort studies and RCTs.
The initial focus of Co_OPT will be on antenatal corticosteroid treatment. With cross-disciplinary expertise, and data from thirteen datasets (1.5million women and their children) Co_OPT will
- Describe how antenatal corticosteroid treatment is used across a variety of settings.
- Determine the short and long-term outcomes of antenatal corticosteroids in women and babies who are treated and subsequently deliver at term (unnecessary treatment), or deliver >7 days after administration (inappropriately timed treatment), or receive antenatal corticosteroids to cover early term delivery.
- Determine characteristics that influence maternal and infant outcomes following ACT, develop predictive models for their use and determine best formulation and dose regimens.
|Dr Sarah Stock||Chief Investigator|
Dr Sarah Stock: firstname.lastname@example.org
- Kemp MW, Jobe AH, Usuda H, Nathanielsz PW, Li C, Kuo A, Huber HF, Clarke GD, Saito M, Newnham JP, Stock SJ. Efficacy and Safety of Antenatal Steroids. Am J Physiol Regul Integr Comp Physiol. 2018 Apr 11. doi: 10.1152/ajpregu.00193.2017.
- Agnew EJ, Ivy JR, Stock SJ, Chapman KE. Glucocorticoids, antenatal corticosteroid therapy and fetal heart maturation. J Mol Endocrinol. 2018 Jul;61(1):R61-R73. doi: 10.1530/JME-18-0077. Epub 2018 May 2.
- Kemp MW, Newnham JP, Challis JG, Jobe AH, Stock SJ. The clinical use of corticosteroids in pregnancy. Hum Reprod Update. 2015 Nov 20.
Professor K Allergaert (KU Leuven, Belgium)
Associate Professor C Bannerman-Gyamfi (Columbia University, USA)
Dr Jasper Been (Erasmus MC, Netherlands)
Dr S Bhattacharya (University of Aberdeen, UK)
Associate Professor K Einarsdottir (Centre for Health Sciences, University of Iceland)
Dr Abigail Fraser (University of Bristol)
Professor M Gissler (National Institute of Health and Welfare, Finland)
Professor Lani Florian (University of Edinburgh)
Professor B Jacobsson (Sahlgrenska Academy, University of Gothenburg, Sweden)
Professor S Kuhle (Dalhousie University, Canada)
Pamela Linksted (NHS Lothian, UK)
Simone Cramer (European Foundation for the Care of Newborn Infants)
Professor B Mol (University of Adelaide, Australia)
Professor Jane Norman (University of Edinburgh, UK)
Associate Professor L Pedersen (Aarhus University, Denmark)
Professor R Reynolds (University of Edinburgh, UK)
Professor R Riley (University of Keele, UK)
Dr A Roberts (King’s College London)
Dr D Roberts (Liverpool Women's Hospital, UK)
Professor D Robertson (University of Edinburgh)
Assistant Professor E Schuit (UMC Utrecht, the Netherlands)
Dr J Vogel (Maternal and Perinatal Health, WHO)
Dr Rachael Wood (University of Edinburgh)
Professor J Wright (Bradford Institute for Health Research, UK)
Partners and Funders
European Foundation for the Care of Newborn Infants
June 2018 - May 2023
Pregnancy, Antenatal corticosteroids, Medicines, Preterm, Stillbirth, Perinatal Mortality, Neurodevelopment
Natural Language Processing, Individual Patient Data Level Meta-analysis (IPD meta-analysis), Predictive models, Cohort