Precision Medicine Doctoral Training Programme

21/22 Projects

Listing of available projects for 21/22 entry.

Applications for all projects must be submitted via the University of Edinburgh's Degree FinderPlease include a CV with your application. Your CV can be uploaded to the Research Proposal section of your application.

 

UNIVERSITY OF GLASGOW PROJECTS

University of Glasgow Lead projects can be found here.

 

UNIVERSITY OF EDINBURGH PROJECTS

PROJECT TITLE SUPERVISOR
Predicting rehabilitation needs and trajectories in older patients                           Dr Atul Anand
5α-Reductases: Mapping pathways of Metabolic Disease     Prof Ruth Andrew
Understanding the long term evolution of HIV drug resistance  Dr Katie Atkins
Development of clinically relevant models of undifferentiated pleomorphic sarcoma using a genetic screening approach Prof Val Brunton
Identifying therapeutic targets for human chronic wounds using single cell transcriptomics and digital spatial profiling  Dr Jenna Cash

Which human diseases are caused by cellular senescence? When to use senolytic therapy?

Dr Tamir Chandra
Mitochondrial double-stranded RNA driven innate immune activation in mitochondrial cytopathies Prof Yanick Crow
Non-adherence to medication and drug toxicity: tuberculosis treatment in the era of the World Health Organization’s End Tuberculosis Strategy Prof James Dear
Use of artificial intelligence for community-based detection of glaucoma Prof Baljean Dhillon
Investigating the metabolic alterations that initiate pre-neoplastic development in zebrafish and in humans Dr Yi Feng
Genomics of bacterial coinfections from COVID-19 patients: insights into disease severity and antimicrobial resistance Prof Ross Fitzgerald
Data-driven insights into Precision Medicine training Dr Kobi Gal
Synthetic chromosomes to understand genome instability Prof Nick Gilbert

The Oral-Gut Microbiome Axis in Crohn’s disease and Ulcerative Colitis: Developing a fundamental understanding of the interplay between oral and gut microbiota in disease susceptibility and progression 

Dr Gwo-tzer Ho
Harnessing genome characterisation to uncover disease mechanisms Dr Sara Knott
Air pollution and Dementia: Exploring genetic, cardiovascular, and epigenetic moderators and mechanisms Dr Michelle Luciano
Augmenting clinical risk predictors through multi-omics Dr Riccardo Marioni
Developing Artificial Intelligence approaches to predicting progressive myopia and risk of myopic complications based on optometry data Dr Tom MacGillivray
Analysis of signalling pathways that underlie the development of human haematopoietic stem cells Prof Alexander Medvinksy
Developing globally applicable, cross linguistic cleft speech evaluation to measure cleft palate treatment outcomes, using biomedical speech signal processing and statistical machine learning Dr Felicity Mehendale
Defining the mechanism of photoreceptor cell death in Retinitis Pigmentosa Dr Pleasantine Mill
Targeted ultrasonic contrast enhancement for accurate staging of rectal cancer Prof Carmel Moran
Multiomic Analysis of the Hepatic Fibrotic Niche to Define New Therapeutic Targets for Liver Scarring Dr Prakash Ramachandran
Quantitative predictive modelling for hydrogels: Precision scaffolds with applications to regenerative medicine Prof Lynne Regan
Predictive coding impairment in mouse models of autistic spectrum disorders Dr Nathalie Rochefort
Establishing the role of pathogenetic mechanisms in the evolution of epidemic K. pneumoniae lineages Dr Thamarai Schneiders
Computational modelling human stem cell fitness of pre-leukaemic mutations Dr Linus Schumacher
Developmental consequences and potential therapeutic exploitation of genetic PI 3-kinase activation Prof Robert Semple
Using genetics of biomarkers and Bayesian shrinkage prediction to identify genetic factors of giant cell arteritis and its complications Dr Athina Spiliopoulou
Using modelling and C. elegans to target the molecular mechanisms governing Ca2+-linked cognitive decline  Dr Melanie Stefan
Investigation of long-range connectopathies in autism spectrum disorders using high-throughput single cell projection mapping and 3D imaging Dr Gulsen Surmeli
Assessing the penetrance of genes that contribute to cancer in a large population-based cohort and implementation in a clinical genetics setting Dr Albert Tenesa
Remodelling of cellular RNA metabolism during infection and disease Prof David Tollervey
An Integrated Platform for Exploring the Role of Genomic Complexity in Colorectal Cancer Prof Ian Tomlinson
Cooperative Omics analysis and cell-based studies to position the first-in-class total SRC inhibitor eCF506 towards the right cancer indication Prof Asier Unciti-Broceta
Deciphering the Mechanism That Masks an Endothelial Formylated Peptide Receptor  Dr Sonja Vermeren
Understanding the role of novel microtubule-associated proteins in controlling cell division, organization and shape Dr Julie Welburn
Leveraging proteomics to discover new biology and therapeutic targets Prof James Wilson

iCASE PROJECTS

PROJECT TITLE SUPERVISOR
Antimicrobial peptoids: Investigating the mechanisms of a novel class of therapeutics against the ESKAPE pathogens Dr Madeleine Moule
Strategies for precision gene therapy in the central nervous system Prof Matthew Nolan
Novel computational modelling for personalised treatment of osteoarthritis                              Prof Pankaj Pankaj
Data-driven personalised care for Gestational Diabetes  Prof Rebecca Reynolds
Time-resolved single-cell analysis of neural cell differentiation in motor neuron disease (MND) Dr Christopher Sibley
Inhibition of Zika Virus by Interferon A14 and derivatives    Dr Richard Sloan