Precision Medicine Doctoral Training Programme

20/21 Projects

Listing of available projects for 20/21 entry.

Applications for all projects must be submitted via the University of Edinburgh's Degree FinderPlease include a CV with your application. Your CV can be uploaded to the Research Proposal section of your application.

UNIVERSITY OF EDINBURGH PROJECTS

Title Lead Supervisor
Development of clinically relevant models of undifferentiated pleomorphic sarcoma using a genetic screening approach Prof Val Brunton
Tumour exosome-functionalised magnetic nanoparticles for magnetic resonance imaging guided precision medicine and personalised breast cancer treatment

Dr Michael Chen

Integration of single-cell RNA sequencing data from human and murine kidney disease to identify novel therapeutic targets

Dr Bryan Conway

A step change in sensitivity of Raman spectroscopy for accurate and rapid analysis of living cells

Dr Andy Downes 

Developing Personalised Precision Medical Approaches for Paediatric Intensive Care through Data Informatics and Machine Learning on the Impact of Acute Clinical and Physiological Phenotypes on Outcome

Dr Javier Escudero

Using Omics to Understand the Genes and Pathways Underlying Alcohol Use Disorder 

Dr Kathryn Evans

Investigating the metabolic alterations that initiate pre-neoplastic development in zebrafish and in humans

Dr Yi Feng

Synthetic chromosomes to understand genome instability

Prof Nick Gilbert

Analysis of intestinal metagenomes using ASAR

Prof Igor Goryanin

Taming the Hippo in Cancer through Proteogenomics

Dr Carsten Gram Hansen

Identifying Pathogenic B cells in Rheumatoid Arthritis

Dr Mohini Gray
Illuminating roles of Wnt/b-Catenin signalling in nonalcoholic fatty liver disease (NAFLD) Prof Keisuke Kaji
Reverse-engineering blood flow and transport in complex vascular organs: an in-silico approach to characterising pregnancy pathologies Dr Timm Krüger

Developing data science approaches to improve paediatric critical care patient flows and its related health economics benefits in Scotland

Dr Tsz-Yan Milly Lo
Analysing and recommending personalised care pathways for multimorbid patients with the use of artificial intelligence techniques Dr Areti Manataki

Defining and predicting the molecular basis for male infertility

Dr Joseph Marsh

Comprehensive study of miRNAs biogenesis in human cancer

Dr Gracjan Michlewski
Determining clinically significant early stage lung cancers from image analysis Prof Bill Nailon
Dissecting the biophysics of ocular transcription factors in vivo  Dr Dimitrios Papadopoulos

Stromal transcriptomic signatures in prostate cancer metastasis and hormone therapy resistance

Dr Bin-Zhi Qian
Proteomic analysis of FAK function in human pancreatic cancer Dr Alan Serrels
Large-Scale Data-Driven Lung Cancer Diagnostics using Time-Resolved Fluorescence Spectroscopy (TRFS) Dr Sohan Seth
Data-Driven Decision Making for Paediatric Triage in Acute Care Dr Syed Ahmar Shah
Molecular dynamics of the response to breast cancer therapies Dr Andy Sims
Investigation of long-range connectopathies in autism spectrum disorders using high-throughput single cell projection mapping and 3D imaging Dr Gülşen Surmeli
A personalised automatic approach for assessing and modelling the brain deep tissue waste drainage related structures Dr Maria del C. Valdés Hernández
Leveraging protein quantitative trait loci to discover new biology and therapeutic targets Prof James F Wilson

iCASE PROJECTS

An integrated computational-experimental approach to identify and optimise combination drug therapy for non-alcoholic fatty liver disease (NAFLD)                      Prof Jonathan Fallowfield
Modelling Sex Dependent Differences in Human Liver Disease using Stem Cell Derived Models and Organ on a Chip Devices Dr David Hay
High-Precision Tools for Intraoperative Brain Cancer Surgery  Dr Marc Vendrell