Edinburgh Clinical Trials

Publications 2008 to 2013

A list of publications.

2013

Burton C, McKinstry B, Szentagotai TA, et al. Activity monitoring in patients with depression: a systematic review. J Affect Disord 2013; 145(1):21-28.

Cameron EJ, Chaudhuri R, Mair F, McSharry C, Greenlaw N, Weir CJ, Jolly L, Donnelly I, Gallacher K, Morrison D, Spears M, Evans TJ, Anderson K, Thomson NC. (2013) Randomized controlled trial of azithromycin in smokers with asthma. European Respiratory Journal, in press.

CLOTS (Clots in Legs Or sTockings after Stroke) Trials Collaboration. Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3): a multicentre randomised controlled trial. Lancet 2013;382(9891):516-24

Dolan M., Peters A. & Bulley, C. Postural Management in Multiple Sclerosis: The Results and Implications of a Survey and Stakeholder Event. (2013) Posture and Mobility, 30(1): 18-22

Davidson E, Simpson C, Demiris G, Sheikh A, McKinstry B: Integrating Telehealth Care-Generated Data With the Family Practice Electronic Medical Record: Qualitative Exploration of the Views of Primary Care Staff. DOI:10.2196/ijmr.2820. Interact J Med Res 2013 | vol. 2 | iss. 2 | e29.

Espie CA, Hames P, McKinstry B. Use of the Internet and Mobile Media for Delivery of Cognitive Behavioral Insomnia Therapy. Sleep Medicine Clinics 2013; 8(3):407-419

Fairbrother P, McKinstry B et al. Telemonitoring for chronic heart failure: the views of patients and healthcare professionals - a qualitative study. J Clin Nurs 2013.

Fairbrother P, Pinnock H, Hanley J, McKinstry B et al. Exploring telemonitoring and self-management by patients with chronic obstructive pulmonary disease: A qualitative study embedded in a randomized controlled trial. Patient Educ Couns 2013; in press.

Fairbrother P, McCloughan L, Adam G, Brand R, Brown C, Watson M, Cotter N, Mackellaig J, McKinstry B: Involving patients in clinical research: the Telescot Patient Panel. Health Expectations, Sept 2013, DOI: 10.1111/hex.12132.

Gibbison B, Griggs K, Mukherjee M, Sheikh A. Ten years of asthma admissions to adult critical care units in England and Wales. BMJ Open 2013;3:e003420. doi:10.1136/bmjopen-2013-003420

Grant A, Ure J, Nicolson DJ, Hanley J, Sheikh A, McKinstry B et al. Acceptability and perceived barriers and facilitators to creating a national research register to enabl 'direct to patient' enrolment into research: the Scottish Health Research Register (SHARE). BMC Health Serv Res 2013; 13(1):422.

Hanley J, Ure J, Pagliari C, Sheikh A, McKinstry B. Experiences of patients and professionals participating in the HITS home blood pressure telemonitoring trial: a qualitative study. (2013). BMJ Open;3:e002671.

Hogg R, Ritchie D, Wood C, Huby G. (2013) Parenting support for families with young children - a public health, user focused study undertaken in a semi-rural area of Scotland. Journal of Clinical Nursing 22, 1140 - 1150.

Hogg R, Gray C, Kennedy C, Hanley J. (2013) Supporting the case for “progressive universalism” in health visiting: Scottish mothers and health visitors’ perspectives on targeting and rationing health visiting services, with a focus on the Lothian Child Concern Model. Journal of Clinical Nursing 22(1-2), 240-250.

Jaki T, Clive S, Weir CJ. Principles of dose finding studies in cancer: a comparison of trial designs. Cancer Chemotherapy and Pharmacology 2013; 71: 1107-1114

Legg L, Weir CJ, Langhorne P, Smith LN, Stott DJ. Is informal caregiving independently associated with poor health? A population-based study. Journal of Epidemiology and Community Health 2013; 67: 95-97

McArthur KS, Johnson PCD, Quinn TJ, Higgins P, Langhorne P, Walters MR, Weir CJ, Dawson J, Lees KR. (2013) Improving the efficiency of stroke trials: feasibility and efficacy of group adjudication of functional end points. Stroke, 44(12):3422-3428.

McKinstry B, Hanley J, Wild S, Pagliari C, Paterson M, Lewis S, Sheikh A, Krishan A, Stoddart A, Padfield P. Telemonitoring-based service redesign for the management of difficult-to-control hypertension (HITS): a multi-centre randomised controlled trial. BMJ 2013;346:f3030

McKinstry B, Sheikh A. The use of global positioning systems in promoting safer walking for people with dementia. J Telemed Telecare 2013; 19(5):288-292.

McKinstry B, Sheikh A. The use of global positioning systems in promoting safer walking for people with dementia. J Telemed Telecare July 2013 vol. 19 no. 5 288-292 doi: 10.1177/1357633X13495481

McKinstry B. Currently available smartphone apps for asthma have worrying deficiencies. Evid Based Med 2013; 18(5):e45

McKinstry B. The use of remote monitoring technologies in managing chronic obstructive pulmonary disease. Quarterly Journal of Medicine 2013. In press doi hct068 [pii];10.1093/qjmed/hct068 [doi]

McLean S, Sheikh A, Cresswell K, Nurmatov U, Mukherjee M, Hemmi A, Pagliari C The Impact of Telehealthcare on the Quality and Safety of Care: A Systematic Overview; PLoS One. 2013; 8(8): e71238.

McMillan TM, Weir CJ, Ireland A, Stewart E. The Glasgow Outcome at Discharge Scale: an inpatient assessment of disability after brain injury. Journal of Neurotrauma 2013; 30: 970-974

Morgan TC, Dawson J, Spengler D, Lees KR, Aldrich C, Mishra NK, Lane K, Quinn TJ, Diener-West M, Weir CJ, Higgins P, Rafferty M, Kinsley K, Ziai W, Awad I, Walters MR, Hanley D, the CLEAR and VISTA Investigators. The Modified Graeb Score: an enhanced tool for intraventricular hemorrhage measurement and prediction of functional outcome. Stroke 2013; 44: 635-641

Pagliari C, Wolters M, Burton C, McKinstry B, Szentafgotai A, Serrano Blanco A, Ferrini L, Albertini S, Castro JC, Estévez S: Psychosocial Implications of Avatar Use in Supporting Theraphy of Depression. Accepted: CYBER17-17th Annual CyberPsychology & CyberTherapy Conference, Brussels, Belgium.

Pagliari, C,. Burton, C, McKinstry, B, et al.Psychosocial implications of avatar use in supporting therapy for depression. Stud.Health Technol.Inform. 2013; 181:329-33

Pinnock H, Hanley J, McKinstry B et al. Impact of telemonitoring for chronic obstructive pulmonary disease (COPD) on hospitalisation: a randomised controlled trial. BMJ in press

Pinnock H, Hanley J, McCloughan L, Todd A, Krishan A, Lewis S, Stoddart A, Van der Pol M, MacNee W, Sheikh A, Pagliari C, McKinstry B. (2013) Effectiveness of telemonitoring integrated into existing clinical services on hospital admission for exacerbation of chronic obstructive pulmonary disease: researcher blind, multicentre, randomised controlled trial. BMJ 2013; 347:f6070 doi: 10.1136/bmj.f6070

Spears M, McSharry C, Chaudhuri R, Weir CJ, de Wet C, Thomson NC. (2013) Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines—an exploratory study. PLoS ONE, 8(8):e71460. doi:10.1371/journal.pone.0071460

Stoddart A, Hanley J, Wild S, Pagliari C, Paterson M, Lewis S, Sheikh A, Krishan A, Padfield P, McKinstry B. Telemonitoring-based service redesign for the management of difficult-to-control hypertension (HITS): A cost and cost-effectiveness analysis. BMJ Open 2013;3:e002681

Thanacoody HKR, Gray A, Dear JW, Coyle J, Sandilands EA, Webb DJ, Lewis S, Eddleston M, Thomas SHL, Bateman DN. Scottish and Newcastle Antiemetic Pre-treatment for Paracetamol Poisoning Study (SNAP). BMC Pharmacology and Toxicology 2013;14:20

Walsh TS, Boyd JA, Watson D, Hope D, Lewis S, Krishan A, Forbes JF, Ramsay P, Pearse R, Wallis C, Cairns C, Cole S, Wyncoll D; RELIEVE investigators. Restrictive versus liberal transfusion strategies for older mechanically ventilated critically ill patients: a randomized pilot trial. Critical Care Medicine 2013;41(10):2354-63.

Wardlaw J, Muir KW, MacLeod MJ, Weir C, McVerry F, Carpenter T, Shuler K, Thomas R, Acheampong P, Dani K, Murray A. Clinical relevance and practical implications for trials of perfusion and angiographic imaging in patients with acute ischaemic stroke: a multicentre cohort imaging study. Journal of Neurology, Neurosurgery and Psychiatry published online 3 May 2013

Wild S, Hanley J, McKinstry B et al. The impact of supported telemetric monitoring in people with type 2 diabetes: study protocol for a randomised controlled trial. Trials 2013; 14 (1): 198.

CARC

RELINQUISH study Ramsay P, Huby G, Rattray J, Salisbury LG, Walsh TS, Kean S. (2013) A longitudinal qualitative exploration of healthcare and informal support needs among survivors of critical illness: the RELINQUISH protocol. BMJ open. 2(4)

Chandler A. Whittaker A. Williams N. McGorm K. Cunningham-Burley S. Matthews G. (in press) Mother’s little helper? Contrasting accounts of benzodiazepine and methadone use among drug-dependent parents in the UK, Drugs: Education, Prevention and Policy.

Chandler A. Whittaker A. Cunningham-Burley S. Williams N. McGorm K. Mathews G. (2013) Substance, stigma and structure: Parents in the UK accounting for opioid substitution therapy during the antenatal and postnatal periods, International Journal of Drug Policy, 24, 6, e35-42. 10.1016/j.drugpo.2013.04.004

Good practice guidance: Whittaker A. Templeton L, Mitchell F. Hill L. Neilson A. (in press) Practitioner Toolkit: Getting it right for children and families affected by parental problem alcohol and drug use, Edinburgh, NHS Lothian.

2012

Alexandru, C.A. McKinstry, B. (2012) Usability Evaluation of Clinician Web Back Ends to Telemonitoring Systems: Two Case Studies in Scotland, Studies in Informatics and Control, ISSN 1220 1766, vol. 21 (2) pp. 181 190.

Barr L, Brittan M, Conway Morris A, Stewart A, Dhaliwal K, Anderson N, Turner M, Manson L, Simpson AJ. Pulmonary and systemic effects of mononuclear leukapheresis. Vox sanguinis 2012;103(4):275-83. DOI: 10.1111/j.1423-0410.2012.01611.x

Brittan M, Barr L, Conway Morris A, Duffin R, Rossi F, Johnston S, Monro G, Anderson N, Rossi AG, McAuley DF, Haslett C, Hirani N, Dhaliwal K, Simpson AJ. A novel subpopulation of monocyte-like cells in the human lung after lipopolysaccharide inhalation. Eur Respir J 2012;40:206–14. DOI: 10.1183/09031936.00113811

Burton, C., McKinstry, B., Szentagotai, T.A., Serrano?Blanco, A., Pagliari, C., Wolters, M. (2012) Activity monitoring in patients with depression: A systematic review. J Affect Disord. Aug 4 [Epub ahead of print]

Chaudhuri R, McSharry C, Brady J, Donnelly I, Grierson C, McGuinness S, Jolly L, Weir CJ, Messow CM, Spears M, Miele G, Nocka K, Crowther D, Thompson J, Brannigan M, Lafferty J, Sproule M, MacNee W, Connell M, Murchison JT, Shepherd MC, Feuerstein G, Miller DK, Thomson NC. Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. Journal of Allergy and Clinical Immunology 2012; 129: 655-663

Chouliara, Z., Karatzias, T., Scott-Brien, G., Macdonald, A., MacArthur, J. Frazer N. (2012). Perspectives of Services for Adult Survivors of Childhood Sexual Abuse (CSA): A Systematic Review of the Literature. Journal of Counselling and Psychotherapy Research, 1, pp.1-16.

Cowey, E., Smith, L.N., Booth, J., Weir, C.J. (2012) Urinary catheterisation in stroke: clinical realities. A mixed methods study. Clinical Rehabilitation. 26(5) pp.470-9.

Fairbrother, P., Pinnock, H., Hanley, J., McCloughan, L., Sheikh, A., Pagliari, C. et al. (2012) Continuity, but at what cost? The impact of telemonitoring COPD on continuities of care: a qualitative study. Prim Care Respir Journal 21(3) pp.322-328.

Fairbrother P, McKinstry B et al. Continuity, but at what cost? The impact of telemonitoring COPD on continuities of care: a qualitative study. Prim Care Respir J 2012; 21(3):322-328.

Gray, C. (2012) Three into one won’t go. Nursing Standard 26 (42), p69. Hogg, R., Gray, C., Kennedy, C., Hanley, J. (in press) Supporting the case for “progressive universalism” in health visiting: Scottish mothers and health visitors’ perspectives on targeting and rationing health visiting services, with a focus on the Lothian Child Concern Model. (Journal of Clinical Nursing - in press).

Gray Brunton C, Hogg R, Kennedy C et al. Young women’s experiences of the HPV vaccine: a Cross-Cultural, Qualitative Study in Scotland, Spain, Serbia and Bulgaria. International Journal of Behavioural Medicine (in press)

Hogg R. Making Scotland the Best Place for a child to Grow Up (Guest Editorial). Journal of Health Visiting 1(9), 494.

Horne AW, Critchley HO, Doust A, Fehr D, Wilson J, Wu O, Jack S, Porter M, Lewis S, Bhattacharya S. GAPP: a pilot randomised controlled trial of the efficacy of action of gabapentin for the management of chronic pelvic pain in women: study protocol. BMJ open 2012;2:e001297

Huang JT-J, Chaudhuri R, Albarbarawi O, Barton A, Grierson C, Rauchhaus P, Weir CJ, Messow M, Stevens N, McSharry C, Feuerstein G, Mukhopadhyay S, Brady J, Palmer CNA, Miller D, Thomson NC. Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax 2012; 67: 502-508

The IST-3 collaborative group. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. Lancet 2012;379:2352-63

Jackson, A.M., McKinstry, B., Gregory, S., Amos, A. (2012) A qualitative study exploring why people do not participate in cardiac rehabilitation and coronary heart disease self?help groups, and their rehabilitation experience without these resources. Prim Health Care Res Dev; 13 (1):pp.30-41.

Kennedy C, Gray Brunton C, Hogg R. ‘Just that little bit of doubt’: Scottish Parents, Teenage Girls’ and Health Professionals’ views of the MMR, H1N1 and HPV vaccines. International Journal of Behavioural Medicine (in press)

Legg LA, Quinn TJ, Mahmood F, Weir CJ, Tierney J, Stott DJ, Smith LN, Langhorne P. Nonpharmacological interventions for caregivers of stroke survivors. Stroke 2012; 43: e30-e31

McLean, S.C., McKinstry, B. (2012) Meta-analysis on COPD: comment on 'Home telehealth for chronic obstructive pulmonary disease: a systematic review and meta?analysis. by J Polisena et al.'. J Telemed Telecare; 18(4):242.

McLean SC., McKinstry B. Meta-analysis on COPD: comment on 'Home telehealth for chronic obstructive pulmonary disease: a systematic review and meta-analysis. by J Polisena et al.' Letter Journal of Telemedicine and Telecare. 2012; 18(4) 242

Newby DE, Williams MC, Flapan AD, Forbes JF, Hargreaves AD, Leslie SJ, Lewis SC,et al, for the SCOT-HEART trialists. Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial. Trials 2012;13(1):184

Pagliari, C., Burton, C., McKinstry, B., Szentatotai, A., David, D., Serrano, B.A. et al. (2012) Psychosocial implications of avatar use in supporting therapy for depression. Stud Health Technol Inform; 181:pp. 329-333.

Pilcher, M., MacArthur, J. (2012) Patient experiences of bladder problems following stroke. Nursing Standard 26(36) pp.39-46.

Reed MJ, Mills NL, Weir CJ. Sensitive troponin assay predicts outcome in syncope. Emergency Medicine Journal 2012; 29: 1001-1003

Walsh TS, Salisbury LG, Boyd J, Ramsey P, Merriweather J, Huby G, Forbes J, Rattray J, Griffiths D, Mackenzie S, Hull A, Lewis S, Murray G. A Randomised Controlled Trial Evaluating a Rehabilitation Complex Intervention for patients following Intensive Care Discharge. The RECOVER study. BMJ Open 2012;2:e001475

Wilson C, Hogg R, Henderson M, Wilson P Patterns of Primary Care Service use by Families with Young Children. Family Practice (in press)

CARC

Ramsay, P., Huby, G., Rattray, J., Salisbury, L., Walsh, T., Kean, S. (2012) A longitudinal qualitative exploration of healthcare and informal support needs among survivors of critical illness: the RELINQUISH protocol. BMJ Open

2011

Black, A.D., Car, J., Pagliari, C., Anandan, C., Cresswell, K., Bokun, T. et al. (2011) The impact of eHealth on the quality and safety of health care: a systematic overview. PLoS Med; 8(1):e1000387.

Braganza, G., Chaudhuri, R., McSharry, C., Weir, C.J., Donnelly, I., Jolly, L., Lafferty, J., Lloyd, S.M., Spears, M., Mair, F., Thomson, N.C. (2011) Effects of short-term treatment with atorvastatin in smokers with asthma ? a randomized controlled trial. BMC Pulmonary Medicine 11:16.

Brown, M., MacArthur, J., McKechanie, A., Mack, S., Hayes, M. & Fletcher, J. (2011) Learning Disability Liaison Nursing Services in southeast Scotland: a mixed-methods impact and outcome study. Journal of Intellectual Disability Research doi: 10.1111/j.1365?2788.2011.01511.x

Chouliara, Z., Karatzias, T., Scott-Brien, G., Macdonald, A., MacArthur, J. Frazer N. (2011). Talking Therapy Services for Adult Survivors of Childhood Sexual Abuse (CSA) in Scotland: Perspectives of Service Users and Professionals. Child Sexual Abuse, 20, pp.1-29.

Coupar, F., Pollock, A., Rowe, P., Weir, C., Langhorne, P. (2011) Predictors of upper limb recovery after stroke: a systematic review and metaanalysis. Clinical Rehabilitation 26: pp.291?313.

Gray, C., Kennedy, C., Hogg, R. (2011) Professional Boundary Work in the face of Change to Generalist Working in Community Nursing in Scotland. Journal of Advanced Nursing 67(8), pp.1695-1704

Kennedy, C., Harbison, J., Mahoney, C., Jarvis, A., Veitch, L. (2011) Investigating the contribution of community nurses to anticipatory care: a qualitative exploratory study. Journal of Advanced Nursing. 67 (7):pp. 1558-67.

McKinstry, B., Watson, P., Elton, R.A., Pinnock, H., Kidd, G., Meyer, B. et al. (2011) Comparison of the accuracy of patients' recall of the content of telephone and face-to-face consultations: an exploratory study. Postgrad Med J 87(1028):pp.394-399.

McMillan, T.M., Teasdale, G.M., Weir, C.J., Stewart, E. (2011) Death after head injury: the 13 year outcome of a case control study. J Neurol Neurosurg Psychiatry, Published Online First: 31 January 2011, doi:10.1136/jnnp.2010.222232.

Roberts, C.L., Ford, J.B., Algert, C.S., Antonsen, S., Chalmers, J., Cnattingius, S., Gokhale, M., Kotelchuck, M., Melve, K.K., Langridge, A., Morris, C., Morris, J.M., Nassar, N., Norman, J.E., Norrie, J., Sørensen H.T., Walker, R., Weir, C.J. (2011) Population based trends in pregnancy hypertension and pre-eclampsia: an international comparative study. BMJ Open; published at http://bmjopen.bmj.com on May 24, 2011, doi:10.1136/bmjopen?2011?000101

Seaton, R.A., Sharp, E., Bezlyak, V., Weir, C.J. (2011) Factors associated with outcome and duration of therapy in outpatient parenteral antibiotic therapy (OPAT) patients with skin and soft-tissue infections. International. Journal of Antimicrobial Agents 38:pp.243-248.

Ure, J., Pinnock, H., Hanley, J., Kidd, G., McCall, S.E., Tarling, A. et al. (2012) Piloting tele-monitoring in COPD: a mixed methods exploration of issues in design and implementation. Prim Care Respir J; 21 (1):pp.57-64.

Weir, C., Murray, G. (2011). Fraud in clinical trials. Significance 8(4). doi: 10.1111/j.1740?9713.2011.00521.x

White PM, Lewis SC, Gholkar A, Sellar RJ,Nahser H, Sandercock PAG, Cognard C, Forrester L, Wardlaw JM. Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial. Lancet 2011;377:1655-62

2010

The CLOTS Trial Collaboration. Thigh-length versus below-knee stockings for deep venous thrombosis prophylaxis after stroke. A Randomized Trial. Ann Intern Med 2010;153:553-562.
 
Gomes M, Soares MO, Dumville JC, Lewis SC, Torgerson DJ, Dodenham AR, Gough MJ, Warlow CP. Cost-effectiveness analysis of general anaesthesia versus local anaesthesia for carotid surgery (GALA Trial). Brit J Surgery 2010;97(8):1218-25

2009

The CLOTS trials collaboration. Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial. Lancet 2009;373:1958-65
 
Pinnock H, Hanley J, Lewis S, Macnee W, Pagliari C, van der Pol M, McKinstry B. The impact of a telemetric chronic obstructive pulmonary disease monitoring service: randomised controlled trial with economic evaluation and nested qualitative study. Prim Care Respir J 2009;18(3):233-5

2008

GALA Trial Collaborative Group. General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial. Lancet 2008;372:2132-42 [lead author]
 
Gough MJ, Bodenham A, Horrocks M, Colam B, Lewis SC, Rothwell P, et al. GALA: an international multicentre randomised trial comparing general anaesthesia versus local anaesthesia for carotid surgery. BMC Trials 2008;9:28
 
Sandercock P, Lindley R, Wardlaw J, Dennis M, Lewis S, et al, on behalf of the IST-3 collaborative group. The third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke. BMC Trials 2008;9:37
 
White PM, Lewis SC, Nahser H, Sellar RJ, Goddard T, Gholkar A. Hydrocoil endovascular aneurysm occlusion and packing study (HELPS trial): procedural safety and operator-assessed efficacy results. Am J Neuroradiol 2008;29:217-223