Prediction of Recurrent Events with 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques in Patients with Myocardial Infarction
PRE18FFIR - Heart attacks are caused by a blood clot which stops blood flowing to part of the heart muscle. The blood clots form in areas of blood vessels (arteries) that are damaged (inflamed) by a build-up of small fatty lumps (plaques). The fatty lumps can break and cause blood to stick to the wall of the blood vessel. It appears that this process can also occur without causing any symptoms and may put patients at increased risk of heart attacks in the future. It has also been shown that patients with a heart attack often have more than one damaged plaque. Previous research has shown a specialised scanning technique known as PET (positron emission tomography) using a tracer called 18F-sodium fluoride can identify these damaged plaques in patients with a recent heart attack. The aim of this study is to confirm whether this tracer can be used identify patients who are at risk of having a heart attack or other heart problems in the future.
Chief Investigator: Professor David Newby
Number and location of participating sites (by region/ country): Multicentre study with 7 UK centres based in Aberdeen, Edinburgh, Manchester, Oxford, Leeds, Birmingham and Cambridge. International sites in Los Angeles, USA and Adelaide, Australia.
EudraCT number: 2014-004021-41
The Clinical Trials gov number is NCT02278211.
Funder: Wellcome Trust
Start and End date of grant award: Jan 2015 – Dec 2021
Status: In follow-up
GDPR Privacy Statement: If you have participated in this study and would like to read how it complies with GDPR, please read this document.
Chief Investigator: Professor David Newby, Centre of Cardiovascular Science, Chancellor’s Building, 51 Little France Crescent, Edinburgh EH16 4SB.
Principal Investigator: Marwa Daghem
Trial Manager: Dr Laura Forsyth
ECTU involvement: Trial management, Statistics, Database and randomisation service