MS-SMART
Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial
A multi-arm phase IIb randomised, double blind placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis.
Chief Investigator: Professor Jeremy Chataway
Number and location of participating sites (by region/ country): 10-15 sites in England and Scotland
EudraCT number: 2012-005394-31
ISRCTN number: ISRCTN28440672 (http://www.isrctn.com/ISRCTN28440672)
Funder: MRC EME (Efficacy and Mechanism Evaluation Programme)
Start and End date of grant award: April 2013 to December 2018
Start and End date of reruitment: December 2014 to June 2016 (complete)
Current Status: Published online January 22, 2020 https://doi.org/10.1016/S1474-4422(19)30485-
Professor Jeremy Chataway, Chief Investigator: headline results
Dr Jeremy Chataway, Chief Investigator, presented the headline results at the international MS conference (ECTRIMS) on Friday 12 October. A video aimed at the trial participants is available to view and you can find out the results using this link: www.mssociety.org.uk/ms-smart-results
Website:
Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial
www.thelancet.com/neurologyTrial Unblinding Information: Medical professionals in circumstances where un-blinding is necessary should refer to the protocol/ MS-SMART patient card and follow instructions provided.
UK GDPR privacy statement: https://www.ucl.ac.uk/legal-services/privacy/participants-health-and-care-research-privacy-notice
Contact details
Email: smartectu@ed.ac.uk
Sponsor: University College London, Joint Research Office, UCL Gower Street, London WC1E 6BT. www.ucl.ac.uk/jro
Chief Investigator: Dr Jeremy Chataway, Institute of Neurology, University College London (UCL), The National Hospital for Neurology, and Neurosurgery (NHNN), University College London Hospitals, NHS Foundation Trust , Queen Square, London WC1N 3 BG. jeremy.chataway@uclh.nhs.uk
ECTU Involvement: Trial management, Statistics, Database, Randomisation, Unblinding
(UKCRC)